Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration (Q27331605)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064279%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

title

Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration (English)

1 reference

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1 April 2020

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11

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1 April 2020

author name string

Wei Xu

1

1 reference

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1 April 2020

Fang Fang

4

1 reference

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1 April 2020

Xinyi Wang

5

1 reference

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1 April 2020

Yiwen Wu

6

1 reference

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1 April 2020

Xiaobei Zhao

8

1 reference

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1 April 2020

Mariko Sawa

9

1 reference

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1 April 2020

Shengdi Chen

10

1 reference

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1 April 2020

Jianqing Ding

12

1 reference

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1 April 2020

Chengbiao Wu

14

1 reference

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1 April 2020

April M Weissmiller

2

1 reference

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1 April 2020

Joseph A White

3

1 reference

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1 April 2020

Matthew L Pearn

7

1 reference

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1 April 2020

William C Mobley

13

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1 April 2020

language of work or name

English

0 references

publication date

11 April 2016

1 reference

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Journal of Clinical Investigation

1 April 2020

published in

1 reference

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1 April 2020

volume

126

1 reference

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1 April 2020

issue

5

1 reference

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1 April 2020

page(s)

1815-1833

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describes a project that uses

1 April 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4855914/fullTextXML

inferred from PubMed Central ID database lookup

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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28 September 2017

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Prenylation of Rab5 is dependent on guanine nucleotide binding.

28 September 2017

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Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation

28 September 2017

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TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons

28 September 2017

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Beta-amyloid precursor protein of Alzheimer disease occurs as 110- to 135-kilodalton membrane-associated proteins in neural and nonneural tissues.

28 September 2017

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Nerve growth factor and the basal forebrain cholinergic system: a link in the etiopathology of neurodegenerative dementias?

28 September 2017

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Nerve growth factor and the neurotrophic factor hypothesis

28 September 2017

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Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

A novel method for producing mono-biotinylated, biologically active neurotrophic factors: an essential reagent for single molecule study of axonal transport

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Visualization of larval segmental nerves in 3(rd) instar Drosophila larval preparations.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Mild cognitive impairment in the elderly is associated with volume loss of the cholinergic basal forebrain region

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Purification and culture of nerve growth factor receptor (p75)-expressing basal forebrain cholinergic neurons

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

APP-BP1 inhibits Abeta42 levels by interacting with Presenilin-1.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Nerve growth factor-mediated neurite outgrowth via regulation of Rab5.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Age-dependent loss of NGF signaling in the rat basal forebrain is due to disrupted MAPK activation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Toxic effect of the beta-amyloid precursor protein C-terminus fragment and Na+/Ca2+ gradients.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Loss of cholinergic phenotype in basal forebrain coincides with cognitive decline in a mouse model of Down's syndrome

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Impairment of basal forebrain cholinergic neurons associated with aging and long-term loss of ovarian function

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Age-dependent neuronal and synaptic degeneration in mice transgenic for the C terminus of the amyloid precursor protein.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

A mouse model for Down syndrome exhibits learning and behaviour deficits.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Nerve growth factor increases choline acetyltransferase activity in developing basal forebrain neurons

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Neurofibrillary degeneration of cholinergic and noncholinergic neurons of the basal forebrain in Alzheimer's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Neurofibrillary tangles and senile plaques in aged bears.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target Neurons

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

The neurotoxic carboxy-terminal fragment of the Alzheimer amyloid precursor binds specifically to a neuronal cell surface molecule: pH dependence of the neurotoxicity and the binding

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

A phase 3 trial of semagacestat for treatment of Alzheimer's disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Pharmacodynamics of selective inhibition of γ-secretase by avagacestat.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Retromer binds the FANSHY sorting motif in SorLA to regulate amyloid precursor protein sorting and processing.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Gamma-secretase inhibitors: Notch so bad.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Axonal transport failure in neurodegenerative disorders: the case of Huntington's disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Gamma-secretase: proteasome of the membrane?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Intraneuronal Abeta42 accumulation in Down syndrome brain.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

APP carboxyl-terminal fragment without or with abeta domain equally induces cytotoxicity in differentiated PC12 cells and cortical neurons.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4855914

Semagacestat for treatment of Alzheimer's disease

27 November 2018

1 reference

12 December 2020

Peptide fragments of beta-amyloid precursor protein: effects on parallel fiber-Purkinje cell synaptic transmission in rat cerebellum

1 reference

12 December 2020

Rab5 mediates an amyloid precursor protein signaling pathway that leads to apoptosis

1 reference

12 December 2020

Selective growth stimulating effects of mouse sarcoma on the sensory and sympathetic nervous system of the chick embryo

1 reference

12 December 2020

Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs

1 reference

12 December 2020

1 reference

12 December 2020

Identifiers

DOI

10.1172/JCI82409

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064279%20AND%20SRC:MED&resulttype=core&format=json

OpenCitations bibliographic resource ID

1 April 2020

3186821

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

3186821

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27064279%20AND%20SRC:MED&resulttype=core&format=json

1 April 2020

1 reference