Structural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 Hydroxylase (Q27663638)

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English	Structural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 Hydroxylase	scientific article

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scholarly article

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Structural Evidence for Enhancement of Sequential Vitamin D3 Hydroxylation Activities by Directed Evolution of Cytochrome P450 Vitamin D3 Hydroxylase (English)

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directed evolution

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cholecalciferol

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based on heuristic

inferred from title

Yoshiaki Yasutake

object named as

Yoshiaki Yasutake

1

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Tomohiro Tamura

object named as

Tomohiro Tamura

6

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author name string

Yoshikazu Fujii

2

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Taiki Nishioka

3

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Woo-Kwang Cheon

4

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Akira Arisawa

5

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language of work or name

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publication date

8 October 2010

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Journal of Biological Chemistry

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285

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41

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31193-201

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Selective oxidation of carbolide C-H bonds by an engineered macrolide P450 mono-oxygenase

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20 March 2017

Investigating the structural plasticity of a cytochrome P450: three-dimensional structures of P450 EryK and binding to its physiological substrate.

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20 March 2017

Analysis of Transient and Catalytic Desosamine-binding Pockets in Cytochrome P-450 PikC from Streptomyces venezuelae

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Structure-based design of a highly active vitamin D hydroxylase from Streptomyces griseolus CYP105A1

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20 March 2017

Structural insights from a P450 Carrier Protein complex reveal how specificity is achieved in the P450BioI ACP complex

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20 March 2017

Structural analysis of CYP2R1 in complex with vitamin D3

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20 March 2017

Crystal structure of CYP105A1 (P450SU-1) in complex with 1alpha,25-dihydroxyvitamin D3

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20 March 2017

Filling a hole in cytochrome P450 BM3 improves substrate binding and catalytic efficiency

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20 March 2017

SuperPose: a simple server for sophisticated structural superposition

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20 March 2017

An open conformation of mammalian cytochrome P450 2B4 at 1.6-Å resolution

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20 March 2017

Ketoconazole-induced conformational changes in the active site of cytochrome P450eryF

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20 March 2017

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

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20 March 2017

Crystal structures of ligand complexes of P450eryF exhibiting homotropic cooperativity

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20 March 2017

Structure of cytochrome P450eryF involved in erythromycin biosynthesis

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20 March 2017

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20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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20 March 2017

The many roles of cytochrome b5

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20 March 2017

Evolutionary history of a specialized p450 propane monooxygenase

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20 March 2017

THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE

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7 April 2017

Chemoenzymatic elaboration of monosaccharides using engineered cytochrome P450BM3 demethylases

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29 September 2017

Crystallization and preliminary X-ray diffraction studies of vitamin D3 hydroxylase, a novel cytochrome P450 isolated from Pseudonocardia autotrophica.

1 reference

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29 September 2017

Heme-iron oxygenases: powerful industrial biocatalysts?

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29 September 2017

Engineering cytochrome p450 enzymes

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29 September 2017

Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

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29 September 2017

Supramolecular chemistry of cyclodextrins in enzyme technology

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29 September 2017

Extending the capabilities of nature's most versatile catalysts: directed evolution of mammalian xenobiotic-metabolizing P450s.

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29 September 2017

The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae

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29 September 2017

Identification of the amino acid residue of CYP27B1 responsible for binding of 25-hydroxyvitamin D3 whose mutation causes vitamin D-dependent rickets type 1.

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29 September 2017

Structure and chemistry of cytochrome P450.

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29 September 2017

Characterization of LtsA from Rhodococcus erythropolis, an enzyme with glutamine amidotransferase activity

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Enzymes involved in the activation and inactivation of vitamin D.

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29 September 2017

Cytochrome P450 flexibility

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29 September 2017

Comparison of the dynamics of substrate access channels in three cytochrome P450s reveals different opening mechanisms and a novel functional role for a buried arginine

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29 September 2017

Current understanding of the molecular actions of vitamin D.

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29 September 2017

A simple method for site-directed mutagenesis using the polymerase chain reaction

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29 September 2017

Cytochrome P450: progress and predictions

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29 September 2017

Reverse type I binding spectra of human cytochrome P450 1B1 induced by flavonoid, stilbene, pyrene, naphthalene, phenanthrene, and biphenyl derivatives that inhibit catalytic activity: a structure-function relationship study

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2 June 2018

NMR study on the structural changes of cytochrome P450cam upon the complex formation with putidaredoxin. Functional significance of the putidaredoxin-induced structural changes.

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2 June 2018

Purification, characterization, and directed evolution study of a vitamin D3 hydroxylase from Pseudonocardia autotrophica

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21 January 2018

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PROCHECK: a program to check the stereochemical quality of protein structures

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21 January 2018

Metabolism of vitamin D(3) by human CYP27A1

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Transformation of vitamin D3 to 1 alpha,25-dihydroxyvitamin D3 via 25-hydroxyvitamin D3 using Amycolata sp. strains

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Identifiers

10.1074/JBC.M110.147009

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