Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases (Q27675831)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22120714%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Regulation of lipid binding underlies the activation mechanism of class IA PI3-kinases (English)

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17 January 2020

3

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17 January 2020

author name string

W-C Hon

series ordinal

1

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17 January 2020

A Berndt

series ordinal

2

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17 January 2020

language of work or name

English

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publication date

28 November 2011

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17 January 2020

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17 January 2020

volume

31

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17 January 2020

issue

32

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17 January 2020

page(s)

3655-3666

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Hallmarks of Cancer: The Next Generation

17 January 2020

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Structure of Lipid Kinase p110β/p85β Elucidates an Unusual SH2-Domain-Mediated Inhibitory Mechanism

20 March 2017

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Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34

20 March 2017

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The p110δ structure: mechanisms for selectivity and potency of new PI(3)K inhibitors

20 March 2017

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A frequent kinase domain mutation that changes the interaction between PI3K and the membrane

20 March 2017

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Structural and mechanistic insights into the association of PKC -C2 domain to PtdIns(4,5)P2

20 March 2017

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20 March 2017

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The structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations

20 March 2017

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20 March 2017

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20 March 2017

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Ca(2+) bridges the C2 membrane-binding domain of protein kinase Calpha directly to phosphatidylserine

20 March 2017

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Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation

20 March 2017

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Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers

20 March 2017

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High frequency of mutations of the PIK3CA gene in human cancers

20 March 2017

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Targeting phosphoinositide 3-kinase: moving towards therapy

20 March 2017

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Membrane-protein interactions in cell signaling and membrane trafficking

20 March 2017

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20 March 2017

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Structure of a human inositol 1,4,5-trisphosphate 3-kinase: substrate binding reveals why it is not a phosphoinositide 3-kinase

7 April 2017

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Targeting PI3K signalling in cancer: opportunities, challenges and limitations

20 March 2017

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PI3K pathway alterations in cancer: variations on a theme

7 April 2017

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Membrane recognition by phospholipid-binding domains

7 April 2017

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Dynamics of the phosphoinositide 3-kinase p110δ interaction with p85α and membranes reveals aspects of regulation distinct from p110α

7 April 2017

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A unique spectrum of somatic PIK3CA (p110alpha) mutations within primary endometrial carcinomas

29 September 2017

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H1047R phosphatidylinositol 3-kinase mutant enhances HER2-mediated transformation by heregulin production and activation of HER3

29 September 2017

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PDK1: the major transducer of PI 3-kinase actions

29 September 2017

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Roles for growth factors in cancer progression

29 September 2017

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Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation

29 September 2017

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Regulation of Class IA PI 3-kinases: C2 domain-iSH2 domain contacts inhibit p85/p110alpha and are disrupted in oncogenic p85 mutants

29 September 2017

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Differential enhancement of breast cancer cell motility and metastasis by helical and kinase domain mutations of class IA phosphoinositide 3-kinase

29 September 2017

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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer

29 September 2017

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29 September 2017

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29 September 2017

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PIK3CA cooperates with other phosphatidylinositol 3'-kinase pathway mutations to effect oncogenic transformation

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Rare cancer-specific mutations in PIK3CA show gain of function

29 September 2017

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Determining selectivity of phosphoinositide-binding domains

29 September 2017

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The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

29 September 2017

1 reference

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Mutant PIK3CA promotes cell growth and invasion of human cancer cells

29 September 2017

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The molecular basis of differential subcellular localization of C2 domains of protein kinase C-alpha and group IVa cytosolic phospholipase A2.

29 September 2017

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Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

29 September 2017

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Regulation of the p85/p110alpha phosphatidylinositol 3'-kinase. Distinct roles for the n-terminal and c-terminal SH2 domains

29 September 2017

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Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378484

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors

29 September 2017

1 reference

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Functional analysis of PIK3CA gene mutations in human colorectal cancer

2 June 2018

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Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.

2 June 2018

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Competitive fluorescence polarization assays for the detection of phosphoinositide kinase and phosphatase activity

21 January 2018

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

21 January 2018

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Mapping the phospholipid-binding surface and translocation determinants of the C2 domain from cytosolic phospholipase A2

21 January 2018

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Effects of oncogenic p110alpha subunit mutations on the lipid kinase activity of phosphoinositide 3-kinase

27 November 2018

1 reference

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31 March 2020

Identifiers

DOI

10.1038/ONC.2011.532

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22120714%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

17 January 2020

0 references

1 reference

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17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22120714%20AND%20SRC:MED&resulttype=core&format=json