Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (Q27861934)

26 September 2017

Diversity-oriented synthesis yields novel multistage antimalarial inhibitors (English)

1 reference

phenylalanine--tRNA ligase alpha subunit

26 September 2017

1 reference

10 September 2018

0 references

32

0 references

Gillian L Dornan

Gillian L Dornan

13

0 references

Arvind Sharma

Arvind Sharma

4

0 references

Nicolas M Brancucci

Nicolas M Brancucci

8

0 references

John E Burke

John E Burke

35

0 references

Elamaran Meibalan

Elamaran Meibalan

23

0 references

Sandra Duffy

Sandra Duffy

14

0 references

Vicky M. Avery

Vicky M Avery

33

0 references

Elizabeth Winzeler

Elizabeth A Winzeler

49

0 references

Dyann Wirth

50

Dyann F Wirth

1 reference

26 September 2017

36

Flaminia Catteruccia

1 reference

26 September 2017

47

Daniel E Neafsey

1 reference

26 September 2017

Jacob A McPhail

25

0 references

Amanda K Lukens

20

Amanda K Lukens

1 reference

26 September 2017

9

Joshua A Bittker

1 reference

26 September 2017

52

Stuart L Schreiber

1 reference

26 September 2017

43

Clemens H M Kocken

1 reference

26 September 2017

16

Maurice A Itoe

1 reference

26 September 2017

39

Koen J Dechering

1 reference

26 September 2017

12

Emily R Derbyshire

1 reference

26 September 2017

17

Karin M J Koolen

1 reference

26 September 2017

Nobutaka Kato

1

1 reference

26 September 2017

Eamon Comer

2

1 reference

26 September 2017

Tomoyo Sakata-Kato

3

1 reference

26 September 2017

Manmohan Sharma

5

1 reference

26 September 2017

Micah Maetani

6

1 reference

26 September 2017

Jessica Bastien

7

1 reference

26 September 2017

Victoria Corey

10

1 reference

26 September 2017

David Clarke

11

1 reference

26 September 2017

Sean Eckley

15

1 reference

26 September 2017

Timothy A Lewis

18

1 reference

26 September 2017

Ping S Lui

19

1 reference

26 September 2017

Emily Lund

21

1 reference

26 September 2017

Sandra March

22

1 reference

26 September 2017

Bennett C Meier

24

1 reference

26 September 2017

Branko Mitasev

26

1 reference

26 September 2017

Eli L Moss

27

1 reference

26 September 2017

Morgane Sayes

28

1 reference

26 September 2017

Yvonne Van Gessel

29

1 reference

26 September 2017

Mathias J Wawer

30

1 reference

26 September 2017

Takashi Yoshinaga

31

1 reference

26 September 2017

Sangeeta N Bhatia

34

1 reference

26 September 2017

Jon C Clardy

37

1 reference

26 September 2017

Paul A Clemons

38

1 reference

26 September 2017

Jeremy R Duvall

40

1 reference

26 September 2017

Michael A Foley

41

1 reference

26 September 2017

Fabian Gusovsky

42

1 reference

26 September 2017

Matthias Marti

44

1 reference

26 September 2017

Marshall L Morningstar

45

1 reference

26 September 2017

Benito Munoz

46

1 reference

26 September 2017

Amit Sharma

48

1 reference

26 September 2017

Christina A Scherer

51

1 reference

26 September 2017

language of work or name

English

0 references

publication date

7 September 2016

1 reference

26 September 2017

1 reference

26 September 2017

538

1 reference

26 September 2017

7625

1 reference

26 September 2017

344-349

1 reference

Persistence of Plasmodium falciparum parasitemia after artemisinin combination therapy: evidence from a randomized trial in Uganda

26 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A novel multiple-stage antimalarial agent that inhibits protein synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Plasmodium falciparum genetic crosses in a humanized mouse model

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Killing the hypnozoite--drug discovery approaches to prevent relapse in Plasmodium vivax

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Inhibition of protein synthesis and malaria parasite development by drug targeting of methionyl-tRNA synthetases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Plasmodium falciparum mitochondria import tRNAs along with an active phenylalanyl-tRNA synthetase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Diversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A male and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Plasmodium falciparum transmission stages accumulate in the human bone marrow

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Structures of PI4KIII complexes show simultaneous recruitment of Rab11 and its effectors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

SWISS-MODEL: modelling protein tertiary and quaternary structure using evolutionary information

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

In Vitro Resistance Selections for Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-binding Site and Altered Growth

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Aminoacyl-tRNA synthetases as drug targets in eukaryotic parasites

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Identification of pathogen genomic variants through an integrated pipeline

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Inferring developmental stage composition from gene expression in human malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Targeting Plasmodium PI(4)K to eliminate malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Antimalarial drug discovery - approaches and progress towards new medicines.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Identification of inhibitors of Plasmodium falciparum gametocyte development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Designing the next generation of medicines for malaria control and eradication

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Dynamic steps in receptor tyrosine kinase mediated activation of class IA phosphoinositide 3-kinases (PI3K) captured by H/D exchange (HDX-MS).

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A spectrophotometric assay for quantitative measurement of aminoacyl-tRNA synthetase activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A framework for assessing the risk of resistance for anti-malarials in development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Synthesis and profiling of a diverse collection of azetidine-based scaffolds for the development of CNS-focused lead-like libraries.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

3,5-Diaryl-2-aminopyridines as a novel class of orally active antimalarials demonstrating single dose cure in mice and clinical candidate potential

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Imaging of Plasmodium Liver Stages to Drive Next-Generation Antimalarial Drug Discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Identifying apicoplast-targeting antimalarials using high-throughput compatible approaches

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Validation of isoleucine utilization targets in Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Toward the estimation of the absolute quality of individual protein structure models

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Grand Challenge Commentary: Accessing new chemical space for 'undruggable' targets

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

An Aldol-Based Build/Couple/Pair Strategy for the Synthesis of Medium- and Large-Sized Rings: Discovery of Macrocyclic Histone Deacetylase Inhibitors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Spiroindolones, a potent compound class for the treatment of malaria

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Distinct biological network properties between the targets of natural products and disease genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Chemical genetics of Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Thousands of chemical starting points for antimalarial lead identification

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Extended-connectivity fingerprints

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A hierarchical approach to all-atom protein loop prediction

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

A planning strategy for diversity-oriented synthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Chemical and enzymatic synthesis of tRNAs for high-throughput crystallization

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Complete development of hepatic stages of Plasmodium falciparum in vitro

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5515376

Discovering and developing new medicines for malaria control and elimination

2 June 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

Malaria. Did they really say ... eradication?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

Escape from flatland: increasing saturation as an approach to improving clinical success

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

Microscale culture of human liver cells for drug development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

A microscale human liver platform that supports the hepatic stages of Plasmodium falciparum and vivax

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

High yield preparation of isolated human adult hepatocytes by enzymatic perfusion of the liver

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27602946

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Synthesis of Diverse Lactam Carboxamides Leading to the Discovery of a New Transcription-Factor Inhibitor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27602946

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identification of Plasmodium PI4 kinase as target of MMV390048 by chemoproteomics

1 reference

https://api.crossref.org/works/10.1038%2FNATURE19804

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NATURE19804

1 reference

Dimensions Publication ID

26 September 2017

1032780495

0 references

OpenCitations bibliographic resource ID

2697962

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

26 September 2017

PubMed publication ID

27602946

1 reference