E Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV Evolution (Q28083324)

Crossref

language of work or name

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December 2015

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23

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PubMed

issue

12

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PubMed

page(s)

1819-31

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The structure of AAVrh32.33, a novel gene delivery vector

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Structure of Adeno-Associated Virus Serotype 8, a Gene Therapy Vector

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Cross-dressing the virion: the transcapsidation of adeno-associated virus serotypes functionally defines subgroups

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Mutational analysis of the adeno-associated virus type 2 (AAV2) capsid gene and construction of AAV2 vectors with altered tropism

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ADENOVIRUS-ASSOCIATED DEFECTIVE VIRUS PARTICLES

20 March 2017

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NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells

20 March 2017

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Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes

20 March 2017

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The 'evolvability' of promiscuous protein functions

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Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

20 March 2017

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Central Dogma of Molecular Biology

7 April 2017

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In Silico Reconstruction of the Viral Evolutionary Lineage Yields a Potent Gene Therapy Vector

7 April 2017

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AAV ancestral reconstruction library enables selection of broadly infectious viral variants.

29 September 2017

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High capsid-genome correlation facilitates creation of AAV libraries for directed evolution

29 September 2017

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Improving clinical efficacy of adeno associated vectors by rational capsid bioengineering.

29 September 2017

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Long-term safety and efficacy of factor IX gene therapy in hemophilia B.

29 September 2017

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Genome-wide computational analysis reveals cardiomyocyte-specific transcriptional Cis-regulatory motifs that enable efficient cardiac gene therapy

29 September 2017

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The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing

29 September 2017

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Vector design Tour de Force: integrating combinatorial and rational approaches to derive novel adeno-associated virus variants

29 September 2017

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An immunosufficient murine model for the study of human islets.

29 September 2017

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Liver-specific transcriptional modules identified by genome-wide in silico analysis enable efficient gene therapy in mice and non-human primates

29 September 2017

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Engineering adeno-associated viruses for clinical gene therapy

29 September 2017

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Global CNS transduction of adult mice by intravenously delivered rAAVrh.8 and rAAVrh.10 and nonhuman primates by rAAVrh.10

29 September 2017

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Adeno-associated virus structural biology as a tool in vector development

29 September 2017

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Tropism-modified AAV vectors overcome barriers to successful cutaneous therapy

29 September 2017

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Human skeletal muscle xenograft as a new preclinical model for muscle disorders

29 September 2017

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Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing

29 September 2017

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Selection and evaluation of clinically relevant AAV variants in a xenograft liver model

29 September 2017

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Mutational and fitness landscapes of an RNA virus revealed through population sequencing

29 September 2017

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Robust Long-term Transduction of Common Marmoset Neuromuscular Tissue With rAAV1 and rAAV9.

29 September 2017

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Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design

29 September 2017

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Application of mutated miR-206 target sites enables skeletal muscle-specific silencing of transgene expression of cardiotropic AAV9 vectors.

29 September 2017

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Global CNS gene delivery and evasion of anti-AAV-neutralizing antibodies by intrathecal AAV administration in non-human primates

29 September 2017

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Properties of the adeno-associated virus assembly-activating protein

29 September 2017

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The threefold protrusions of adeno-associated virus type 8 are involved in cell surface targeting as well as postattachment processing

29 September 2017

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Organotypic liver culture models: meeting current challenges in toxicity testing

29 September 2017

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Directed evolution of novel adeno-associated viruses for therapeutic gene delivery.

29 September 2017

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Identification of the heparin binding site on adeno-associated virus serotype 3B (AAV-3B).

29 September 2017

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Adenovirus-associated virus vector-mediated gene transfer in hemophilia B

29 September 2017

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Directed evolution of adeno-associated virus for enhanced gene delivery and gene targeting in human pluripotent stem cells

29 September 2017

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Phase 1 gene therapy for Duchenne muscular dystrophy using a translational optimized AAV vector

29 September 2017

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Enhancing the Clinical Potential of AAV Vectors by Capsid Engineering to Evade Pre-Existing Immunity

29 September 2017

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Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors

29 September 2017

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Inverse zonation of hepatocyte transduction with AAV vectors between mice and non-human primates.

29 September 2017

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Systemic administration of AAV8-α-galactosidase A induces humoral tolerance in nonhuman primates despite low hepatic expression

29 September 2017

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Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer

29 September 2017

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An evolved adeno-associated viral variant enhances gene delivery and gene targeting in neural stem cells

29 September 2017

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MicroRNA-regulated, systemically delivered rAAV9: a step closer to CNS-restricted transgene expression

29 September 2017

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Sequence space and the ongoing expansion of the protein universe

29 September 2017

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Heart-targeted adeno-associated viral vectors selected by in vivo biopanning of a random viral display peptide library

29 September 2017

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Directed evolution of a novel adeno-associated virus (AAV) vector that crosses the seizure-compromised blood-brain barrier (BBB).

29 September 2017

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Reengineering a receptor footprint of adeno-associated virus enables selective and systemic gene transfer to muscle

29 September 2017

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Optimization of stealth adeno-associated virus vectors by randomization of immunogenic epitopes

29 September 2017

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Molecular evolution of adeno-associated virus for enhanced glial gene delivery

29 September 2017

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Successful expansion but not complete restriction of tropism of adeno-associated virus by in vivo biopanning of random virus display peptide libraries

29 September 2017

1 reference

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A myocardium tropic adeno-associated virus (AAV) evolved by DNA shuffling and in vivo selection

29 September 2017

1 reference

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Chimeric AAV Cap sequences alter gene transduction

29 September 2017

1 reference

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Use of human tissue explants to study human infectious agents

29 September 2017

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DNA shuffling of adeno-associated virus yields functionally diverse viral progeny

29 September 2017

1 reference

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Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles

29 September 2017

1 reference

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In vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses

29 September 2017

1 reference

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Enzyme optimization: moving from blind evolution to statistical exploration of sequence-function space

29 September 2017

1 reference

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Characterization of the relationship of AAV capsid domain swapping to liver transduction efficiency

29 September 2017

1 reference

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Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice

29 September 2017

1 reference

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cis effects in adeno-associated virus type 2 replication

29 September 2017

1 reference

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Isolation of targeted AAV2 vectors from novel virus display libraries

29 September 2017

1 reference

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Heparan sulfate proteoglycan binding properties of adeno-associated virus retargeting mutants and consequences for their in vivo tropism

29 September 2017

1 reference

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Directed evolution of adeno-associated virus yields enhanced gene delivery vectors

29 September 2017

1 reference

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Impact of capsid conformation and Rep-capsid interactions on adeno-associated virus type 2 genome packaging

29 September 2017

1 reference

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Filamentous phage display in the new millennium

29 September 2017

1 reference

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Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells

29 September 2017

1 reference

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Novel methods for directed evolution of enzymes: quality, not quantity

29 September 2017

1 reference

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Proteomic profiling of primary retinal Müller glia cells reveals a shift in expression patterns upon adaptation to in vitro conditions

29 September 2017

1 reference

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Identification of a heparin-binding motif on adeno-associated virus type 2 capsids

29 September 2017

1 reference

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Random peptide libraries displayed on adeno-associated virus to select for targeted gene therapy vectors

29 September 2017

1 reference

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In vitro selection of viral vectors with modified tropism: the adeno-associated virus display

29 September 2017

1 reference

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Identification of amino acid residues in the capsid proteins of adeno-associated virus type 2 that contribute to heparan sulfate proteoglycan binding

29 September 2017

1 reference

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Marker rescue of adeno-associated virus (AAV) capsid mutants: a novel approach for chimeric AAV production

29 September 2017

1 reference

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The VP1 capsid protein of adeno-associated virus type 2 is carrying a phospholipase A2 domain required for virus infectivity

29 September 2017

1 reference

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Steps toward mapping the human vasculature by phage display.

29 September 2017

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DNA helicase-mediated packaging of adeno-associated virus type 2 genomes into preformed capsids

29 September 2017

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Monoclonal antibodies against the adeno-associated virus type 2 (AAV-2) capsid: epitope mapping and identification of capsid domains involved in AAV-2-cell interaction and neutralization of AAV-2 infection

29 September 2017

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Viruses at the edge of adaptation.

29 September 2017

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Epitope mapping of human anti-adeno-associated virus type 2 neutralizing antibodies: implications for gene therapy and virus structure

29 September 2017

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Natural Selection and the Concept of a Protein Space

29 September 2017

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Realistic three dimensional fitness landscapes generated by self organizing maps for the analysis of experimental HIV-1 evolution

29 September 2017

1 reference

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Adeno-associated virus capsid proteins may play a role in transcription and second-strand synthesis of recombinant genomes

2 June 2018

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Evidence for pH-dependent protease activity in the adeno-associated virus capsid

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Effects of transient immunosuppression on adenoassociated, virus-mediated, liver-directed gene transfer in rhesus macaques and implications for human gene therapy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Efficient AAV1-AAV2 hybrid vector for gene therapy of hemophilia

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Mutations on the external surfaces of adeno-associated virus type 2 capsids that affect transduction and neutralization

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Generation and characterization of chimeric recombinant AAV vectors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Transendocardial delivery of AAV6 results in highly efficient and global cardiac gene transfer in rhesus macaques

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Efficient intracerebral delivery of AAV5 vector encoding human ARSA in non-human primate.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Efficient transduction of non-human primate motor neurons after intramuscular delivery of recombinant AAV serotype 6.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Altering AAV tropism with mosaic viral capsids.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Directed evolution of industrial enzymes

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4700111

Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles

27 November 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FMT.2015.173