Changing the face of kynurenines and neurotoxicity: therapeutic considerations (Q28085041)

International Journal of Molecular Sciences

language of work or name

1 reference

29 April 2015

2 references

19 November 2019

2 references

19 November 2019

16

1 reference

issue

5

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page(s)

9772-93

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Creative Commons Attribution

copyright license

1 reference

19 November 2019

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Kynurenic acid as a ligand for orphan G protein-coupled receptor GPR35

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Comparative inhibition by substrate analogues 3-methoxy- and 3-hydroxydesaminokynurenine and an improved 3 step purification of recombinant human kynureninase

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Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types

20 March 2017

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7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex

20 March 2017

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Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals

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The brain metabolite kynurenic acid inhibits alpha7 nicotinic receptor activity and increases non-alpha7 nicotinic receptor expression: physiopathological implications

6 April 2017

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Indoleamine 2,3 dioxygenase and quinolinic acid immunoreactivity in Alzheimer's disease hippocampus

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Human microglia convert l-tryptophan into the neurotoxin quinolinic acid

20 March 2017

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Quinolinic acid: a potent endogenous excitant at amino acid receptors in CNS

20 March 2017

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Quinolinic acid is a potent lipid peroxidant in rat brain homogenates

20 March 2017

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Increased brain concentrations of a neurotoxin, 3-hydroxykynurenine, in Huntington's disease

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Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease

20 March 2017

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Kynurenic acid concentrations are reduced in Huntington's disease cerebral cortex

20 March 2017

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Functional G-protein-coupled receptor 35 is expressed by neurons in the CA1 field of the hippocampus

20 March 2017

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Dioxin-receptor ligands in urban air and vehicle exhaust

20 March 2017

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Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine

20 March 2017

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7 April 2017

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7 April 2017

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Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains

7 April 2017

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Targeting key dioxygenases in tryptophan-kynurenine metabolism for immunomodulation and cancer chemotherapy

29 September 2017

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Cellular mechanisms and physiological consequences of redox-dependent signalling

29 September 2017

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Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases.

29 September 2017

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Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production.

29 September 2017

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Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.

29 September 2017

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The role of the immune system in Huntington's disease

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Kynurenines in the CNS: recent advances and new questions.

29 September 2017

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3-Hydroxykynurenine: an intriguing molecule exerting dual actions in the central nervous system

29 September 2017

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Some molecular mechanisms of dopaminergic and glutamatergic dysfunctioning in Parkinson's disease.

29 September 2017

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29 September 2017

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Mechanism of oxidative stress in neurodegeneration

29 September 2017

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Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors

29 September 2017

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The kynurenine system and immunoregulation

29 September 2017

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Kynurenine 3-monooxygenase inhibition in blood ameliorates neurodegeneration

29 September 2017

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Neopterin production and tryptophan degradation during 24-months therapy with interferon beta-1a in multiple sclerosis patients

29 September 2017

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Characterization of the kynurenine pathway in NSC-34 cell line: implications for amyotrophic lateral sclerosis

29 September 2017

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HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

29 September 2017

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Glutamate receptors, neurotoxicity and neurodegeneration

29 September 2017

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Kynurenic acid is a potent endogenous aryl hydrocarbon receptor ligand that synergistically induces interleukin-6 in the presence of inflammatory signaling

29 September 2017

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Syntheses, transformations and pharmaceutical applications of kynurenic acid derivatives

29 September 2017

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The excitotoxin quinolinic acid induces tau phosphorylation in human neurons

29 September 2017

1 reference

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On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo

29 September 2017

1 reference

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Kynurenine diminishes the ischemia-induced histological and electrophysiological deficits in the rat hippocampus

29 September 2017

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Abnormal liver development and resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity in mice carrying a mutation in the DNA-binding domain of the aryl hydrocarbon receptor.

29 September 2017

1 reference

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Characterization of the kynurenine pathway in human neurons

29 September 2017

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Prolonged kynurenine 3-hydroxylase inhibition reduces development of levodopa-induced dyskinesias in parkinsonian monkeys

29 September 2017

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Mitochondria, metabolic disturbances, oxidative stress and the kynurenine system, with focus on neurodegenerative disorders

29 September 2017

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Indoleamine 2,3-dioxygenase in materno-fetal interaction

29 September 2017

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Cigarette smoke as a trigger for the dioxin receptor-mediated signaling pathway

29 September 2017

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Potential role of N-methyl-D-aspartate receptors as executors of neurodegeneration resulting from diverse insults: focus on memantine

29 September 2017

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Involvement of quinolinic acid in AIDS dementia complex

29 September 2017

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3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon-gamma

29 September 2017

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The tryptophan catabolite picolinic acid selectively induces the chemokines macrophage inflammatory protein-1 alpha and -1 beta in macrophages

29 September 2017

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Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine

29 September 2017

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An in vitro study of the effect of picolinic acid on metal translocation across lipid bilayers

29 September 2017

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Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced

29 September 2017

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Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid

29 September 2017

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Antioxidant activities of some tryptophan metabolites: possible implication for inflammatory diseases

29 September 2017

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Regional brain and cerebrospinal fluid quinolinic acid concentrations in Huntington's disease

29 September 2017

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Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue

29 September 2017

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beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

29 September 2017

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Plasma and cerebrospinal fluid tryptophan in multiple sclerosis and degenerative diseases

29 September 2017

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Analysis of the aryl hydrocarbon receptor (AhR) signal transduction pathway

29 September 2017

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Decreased level of kynurenic acid in cerebrospinal fluid of relapsing-onset multiple sclerosis patients

2 June 2018

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Quinolinic acid stimulates synaptosomal glutamate release and inhibits glutamate uptake into astrocytes

2 June 2018

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IFN-beta1b induces kynurenine pathway metabolism in human macrophages: potential implications for multiple sclerosis treatment

2 June 2018

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2 June 2018

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Quinolinic acid production by macrophages stimulated with IFN-gamma, TNF-alpha, and IFN-alpha.

2 June 2018

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Dysfunction of brain kynurenic acid metabolism in Huntington's disease: focus on kynurenine aminotransferases

2 June 2018

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Experimental convulsions in rats induced by intraventricular administration of kynurenine and structurally related compounds

2 June 2018

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Differential vulnerability of central neurons of the rat to quinolinic acid

2 June 2018

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Effect of 3-hydroxyanthranilic acid on the mitochondrial respiratory system

2 June 2018

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Presence of Kynurenic Acid in the Mammalian Brain

2 June 2018

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Actions of kynurenic acid and quinolinic acid in the rat hippocampus in vivo.

2 June 2018

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Kynurenate and 2-amino-5-phosphonovalerate interact with multiple binding sites of the N-methyl-D-aspartate-sensitive glutamate receptor domain

2 June 2018

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2 June 2018

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2 June 2018

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Kynurenine pathway measurements in Huntington's disease striatum: evidence for reduced formation of kynurenic acid

2 June 2018

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The role of hydrogen peroxide in the in vitro cytotoxicity of 3-hydroxykynurenine

2 June 2018

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Quinolinic acid in cerebrospinal fluid and serum in HIV-1 infection: relationship to clinical and neurological status

2 June 2018

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Kynurenine pathway abnormalities in Parkinson's disease.

2 June 2018

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Synthesis and metabolism of L-kynurenine in rat brain

2 June 2018

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Copper(II) interactions with nonsteroidal antiinflammatory agents. II. Anthranilic acid as a potential. OH-inactivating ligand.

2 June 2018

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Early and progressive accumulation of reactive microglia in the Huntington disease brain

20 June 2018

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Induction of indolamine 2,3-dioxygenase and kynurenine 3-monooxygenase in rat brain following a systemic inflammatory challenge: a role for IFN-gamma?

21 January 2018

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Kynurenic acid has a dual action on AMPA receptor responses.

21 January 2018

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The Janus-face kynurenic acid

21 January 2018

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GPR35 is a functional receptor in rat dorsal root ganglion neurons

21 January 2018

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On the antioxidant properties of kynurenic acid: free radical scavenging activity and inhibition of oxidative stress.

21 January 2018

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Kynurenines impair energy metabolism in rat cerebral cortex.

21 January 2018

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Tryptophan-derived ultraviolet filter compounds covalently bound to lens proteins are photosensitizers of oxidative damage

21 January 2018

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In vitro evidence for an antioxidant role of 3-hydroxykynurenine and 3-hydroxyanthranilic acid in the brain.

21 January 2018

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T cell apoptosis by tryptophan catabolism

21 January 2018

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Mechanism for quinolinic acid cytotoxicity in human astrocytes and neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

The endogenous agonist quinolinic acid and the non endogenous homoquinolinic acid discriminate between NMDAR2 receptor subunits.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Kynurenine pathway metabolism in human astrocytes: a paradox for neuronal protection

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Tryptophan degradation and immune activation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Increased 3-hydroxykynurenine serum concentrations differentiate Alzheimer's disease patients from controls

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Increased neopterin production and tryptophan degradation in advanced Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

3-hydroxykynurenine and other Parkinson's disease biomarkers discovered by metabolomic analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Neostriatal and cortical quinolinate levels are increased in early grade Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

The kynurenine pathway and inflammation in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Endogenous protectant kynurenic acid in amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Kynurenine metabolism in multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Astrocytic activation in relation to inflammatory markers during clinical exacerbation of relapsing-remitting multiple sclerosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Interferon-beta affects the tryptophan metabolism in multiple sclerosis patients

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

The mechanism of inactivation of 3-hydroxyanthranilate-3,4-dioxygenase by 4-chloro-3-hydroxyanthranilate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Effect of kynurenine 3-hydroxylase inhibition on the dyskinetic and antiparkinsonian responses to levodopa in Parkinsonian monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Effect of systemic kynurenine on cortical spreading depression and its modulation by sex hormones in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Protective effect of systemic L-kynurenine and probenecid administration on behavioural and morphological alterations induced by toxic soluble amyloid beta (25-35) in rat hippocampus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Neuroprotection achieved in the ischaemic rat cortex with L-kynurenine sulphate

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Quinolinic acid lesion of the nigrostriatal pathway: effect on turning behaviour and protection by elevation of endogenous kynurenic acid in Rattus norvegicus.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

A novel kynurenic acid analogue: a comparison with kynurenic acid. An in vitro electrophysiological study

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Neuroprotective effects of a novel kynurenic acid analogue in a transgenic mouse model of Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Behavioural studies with a newly developed neuroprotective KYNA-amide.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Modifications on the carboxylic function of kynurenic acid.

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

The effect of quinolinate on rat brain lipid peroxidation is dependent on iron

21 January 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Xanthurenic acid inhibits metal ion-induced lipid peroxidation and protects NADP-isocitrate dehydrogenase from oxidative inactivation

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4463617

Erratum: Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

27 November 2018

1 reference

https://api.crossref.org/works/10.3390%2FIJMS16059772

Activated human microglia produce the excitotoxin quinolinic acid

21 January 2018

1 reference

12 December 2020

Formation of hydroxanthommatin-derived radical in the oxidation of 3-hydroxykynurenine

1 reference

12 December 2020

3-Hydroxykynurenine toxicity on the rat striatum in vivo

1 reference

12 December 2020

The preferred route of kynurenine metabolism in the rat

1 reference

12 December 2020

Characterisation of the major autoxidation products of 3-hydroxykynurenine under physiological conditions

1 reference

12 December 2020

Quinolinic acid and active oxygens. Possible contribution of active Oxygens during cell death in the brain

1 reference

12 December 2020

The effect of quinolinate on rat brain lipid peroxidation is dependent on iron

1 reference

12 December 2020

Protective effect of L-kynurenine and probenecid on 6-hydroxydopamine-induced striatal toxicity in rats: implications of modulating kynurenate as a protective strategy

1 reference

12 December 2020

The effect of hormones and vitamin B6 on urinary excretion of metabolites of the kynurenine pathway

1 reference

12 December 2020

7-chlorokynurenic acid prevents in vitro epileptiform and neurotoxic effects due to kainic acid

1 reference

12 December 2020

Picolinic acid modulates kainic acid-evoked glutamate release from the striatum in vitro

1 reference

12 December 2020

Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species

1 reference

12 December 2020

Histological and ultrastructural changes in the rat brain following systemic administration of picolinic acid

1 reference

12 December 2020

Oxidative reactivity of the tryptophan metabolites 3-hydroxyanthranilate, cinnabarinate, quinolinate and picolinate

1 reference

12 December 2020

Copper--ligand interactions and the physiological free radical processes. Part 3. Influence of histidine, salicylic acid and anthranilic acid on copper-driven Fenton chemistry in vitro

1 reference

12 December 2020

Neuroprotection with a new kynurenic acid analog in the four-vessel occlusion model of ischemia

1 reference

12 December 2020

Different inhibitory effects of kynurenic acid and a novel kynurenic acid analogue on tumour necrosis factor-α (TNF-α) production by mononuclear cells, HMGB1 production by monocytes and HNP1-3 secretion by neutrophils

1 reference

12 December 2020

Comparison of the neurochemical and behavioral effects resulting from the inhibition of kynurenine hydroxylase and/or kynureninase

1 reference

12 December 2020

Systemic administration of 4-chlorokynurenine prevents quinolinate neurotoxicity in the rat hippocampus

1 reference

12 December 2020

Interleukin-2, soluble interleukin-2-receptor, neopterin,l-tryptophan and ?2-microglobulin levels in CSF and serum of patients with relapsing-remitting or chronic-progressive multiple sclerosis

1 reference

12 December 2020