Regulation and function of P-Rex family Rac-GEFs (Q28087472)

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2015

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Small GTPases (journal)

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2

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49-70

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P-Rex1, a PtdIns(3,4,5)P3- and Gbetagamma-regulated guanine-nucleotide exchange factor for Rac

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P-Rex2 regulates Purkinje cell dendrite morphology and motor coordination

20 March 2017

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Regulation of PTEN inhibition by the pleckstrin homology domain of P-REX2 during insulin signaling and glucose homeostasis

20 March 2017

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P-Rex1 and Vav1 cooperate in the regulation of formyl-methionyl-leucyl-phenylalanine-dependent neutrophil responses

20 March 2017

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P-Rex1 - a multidomain protein that regulates neurite differentiation

20 March 2017

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Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration

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GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors

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miR-338-3p suppresses gastric cancer progression through a PTEN-AKT axis by targeting P-REX2a.

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PI3K regulates MEK/ERK signaling in breast cancer via the Rac-GEF, P-Rex1.

29 September 2017

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miR-338-3p suppresses neuroblastoma proliferation, invasion and migration through targeting PREX2a

29 September 2017

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Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts

29 September 2017

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Phosphorylation of P-Rex1 at serine 1169 participates in IGF-1R signaling in breast cancer cells.

29 September 2017

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RAS and RHO families of GTPases directly regulate distinct phosphoinositide 3-kinase isoforms

29 September 2017

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Neuronal Rho GEFs in synaptic physiology and behavior

29 September 2017

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29 September 2017

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A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability

29 September 2017

1 reference

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Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1

29 September 2017

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29 September 2017

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A Gβγ effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis.

29 September 2017

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Role for the guanine nucleotide exchange factor phosphatidylinositol-3,4,5-trisphosphate-dependent rac exchanger 1 in platelet secretion and aggregation

29 September 2017

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Whole genome sequencing of matched primary and metastatic acral melanomas

29 September 2017

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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes

29 September 2017

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INPP4A/INPP4B and P-Rex proteins: related but different?

29 September 2017

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Rac1 drives melanoblast organization during mouse development by orchestrating pseudopod- driven motility and cell-cycle progression

29 September 2017

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Rac signaling in breast cancer: a tale of GEFs and GAPs.

29 September 2017

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Characterization of the Rac guanine nucleotide exchange factor P-Rex1 in platelets

29 September 2017

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Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells

29 September 2017

1 reference

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Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

29 September 2017

1 reference

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Signalling via class IA PI3Ks

29 September 2017

1 reference

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Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase

29 September 2017

1 reference

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Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans

29 September 2017

1 reference

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Vav3-deficient mice exhibit a transient delay in cerebellar development

29 September 2017

1 reference

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Characterization of P-Rex1 for its role in fMet-Leu-Phe-induced superoxide production in reconstituted COS(phox) cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Heterogeneity in gene loci associated with type 2 diabetes on human chromosome 20q13.1.

29 September 2017

1 reference

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Domain-domain interaction of P-Rex1 is essential for the activation and inhibition by G protein betagamma subunits and PKA.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Lack of a significant role of P-Rex1, a major regulator of macrophage Rac1 activation and chemotaxis, in atherogenesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Functions of Rac GTPases during neuronal development.

29 September 2017

1 reference

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Membrane translocation of P-Rex1 is mediated by G protein betagamma subunits and phosphoinositide 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Purification of P-Rex1 from neutrophils and nucleotide exchange assay

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Differential sensitivity of P-Rex1 to isoforms of G protein betagamma dimers

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Phosphorylation of P-Rex1 by the cyclic AMP-dependent protein kinase inhibits the phosphatidylinositiol (3,4,5)-trisphosphate and Gbetagamma-mediated regulation of its activity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

P-Rex1 is a primary Rac2 guanine nucleotide exchange factor in mouse neutrophils

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

P-Rex1 regulates neutrophil function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Role of guanine nucleotide exchange factor P-Rex-2b in sphingosine 1-phosphate-induced Rac1 activation and cell migration in endothelial cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Substrate specificity and recognition is conferred by the pleckstrin homology domain of the Dbl family guanine nucleotide exchange factor P-Rex2.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Regulation of P-Rex1 by phosphatidylinositol (3,4,5)-trisphosphate and Gbetagamma subunits

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Control of vesicular trafficking by Rho GTPases

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Matrix-dependent Tiam1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Protein kinase B and rac are activated in parallel within a phosphatidylinositide 3OH-kinase-controlled signaling pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

P-Rex1 directly activates RhoG to regulate GPCR-driven Rac signalling and actin polarity in neutrophils.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

2 June 2018

1 reference

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The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

SWAP-70 is a guanine-nucleotide-exchange factor that mediates signalling of membrane ruffling

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

A Rac1-independent role for P-Rex1 in melanoblasts

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells

27 November 2018

1 reference

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Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 regulates epinephrine-induced exocytosis of Weibel-Palade bodies.

27 November 2018

1 reference

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Ephrin-B1 controls the columnar distribution of cortical pyramidal neurons by restricting their tangential migration.

27 November 2018

1 reference

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P-Rex2, a Rac-guanine nucleotide exchange factor, is expressed selectively in ribbon synaptic terminals of the mouse retina

27 November 2018

1 reference

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Molecular pathways: P-Rex in cancer.

27 November 2018

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Integrin activation by P-Rex1 is required for selectin-mediated slow leukocyte rolling and intravascular crawling

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

27 November 2018

Signalling: REX rules.

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P-Rex1 participates in Neuregulin-ErbB signal transduction and its expression correlates with patient outcome in breast cancer.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4601503

PREX2, a new breed of cancer gene with too many spots?

27 November 2018

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12 December 2020

Rho GEFs and cancer: linking gene expression and metastatic dissemination

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12 December 2020

Hematopoietic Cell Regulation by Rac1 and Rac2 Guanosine Triphosphatases

1 reference

12 December 2020

Phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 (P-Rex-1), a guanine nucleotide exchange factor for Rac, mediates angiogenic responses to stromal cell-derived factor-1/chemokine stromal cell derived factor-1 (SDF-1/CXCL-12) linked

1 reference

12 December 2020

P-REX1, a Rac guanine exchange factor, links melanocyte development and melanoma progression

1 reference

12 December 2020

10.4161/21541248.2014.973770

Identifiers

DOI

1 reference

1 reference

1 reference

PubMed publication ID

25961466

1 reference