Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant (Q28116653)

4 January 2017

title

Molecular chaperone-mediated rescue of mitophagy by a Parkin RING1 domain mutant (English)

1 reference

DnaJ heat shock protein family (Hsp40) member B6

4 January 2017

0 references

1 reference

negative regulation of inclusion body assembly

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

autophagy

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

25 July 2024

2

Sergey S. Novoselov

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

25 July 2024

4

Michael E. Cheetham

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

25 July 2024

author name string

Johanna M. Rose

series ordinal

1

1 reference

4 January 2017

Philip A. Robinson

series ordinal

3

1 reference

4 January 2017

language of work or name

English

1 reference

National Center for Biotechnology Information

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=20889486

25 July 2024

publication date

1 January 2011

1 reference

full work available at URL

4 January 2017

https://academic.oup.com/hmg/article-pdf/20/1/16/17251550/ddq428.pdf

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20889486/?tool=EBI

25 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

http://hmg.oxfordjournals.org/cgi/content/abstract/20/1/16

25 July 2024

online access status

open access

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20889486/pdf/?tool=EBI

25 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

https://europepmc.org/articles/PMC3000674

25 July 2024

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

https://europepmc.org/articles/PMC3000674?pdf=render

25 July 2024

online access status

open access

content deliverer

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20889486

http://academic.oup.com/hmg/article-pdf/20/1/16/17251550/ddq428.pdf

25 July 2024

https://api.crossref.org/works/10.1093/HMG/DDQ428

1 reference

25 July 2024

published in

Human Molecular Genetics

1 reference

4 January 2017

volume

20

1 reference

4 January 2017

issue

1

1 reference

4 January 2017

page(s)

16–27

1 reference

describes a project that uses

4 January 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3000674/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

1 reference

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Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

20 March 2017

1 reference

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Parkin suppresses unfolded protein stress-induced cell death through its E3 ubiquitin-protein ligase activity

20 March 2017

1 reference

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Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1

20 March 2017

1 reference

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Parkin mediates nonclassical, proteasomal-independent ubiquitination of synphilin-1: implications for Lewy body formation

20 March 2017

1 reference

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PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

20 March 2017

1 reference

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HSJ1 is a neuronal shuttling factor for the sorting of chaperone clients to the proteasome

20 March 2017

1 reference

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Parkin accumulation in aggresomes due to proteasome impairment

20 March 2017

1 reference

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Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

20 March 2017

1 reference

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Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy

20 March 2017

1 reference

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Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function

20 March 2017

1 reference

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Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Cystamine and cysteamine increase brain levels of BDNF in Huntington disease via HSJ1b and transglutaminase

20 March 2017

1 reference

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Hsp70 chaperones: cellular functions and molecular mechanism

20 March 2017

1 reference

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Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

20 March 2017

1 reference

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The Chaperone Environment at the Cytoplasmic Face of the Endoplasmic Reticulum Can Modulate Rhodopsin Processing and Inclusion Formation

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

20 March 2017

1 reference

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PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy

7 April 2017

1 reference

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Drosophila parkin requires PINK1 for mitochondrial translocation and ubiquitinates mitofusin

7 April 2017

1 reference

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Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

7 April 2017

1 reference

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

7 April 2017

1 reference

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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

7 April 2017

1 reference

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The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

p62/SQSTM1 cooperates with Parkin for perinuclear clustering of depolarized mitochondria

7 April 2017

1 reference

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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells

29 September 2017

1 reference

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A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

29 September 2017

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Converging concepts of protein folding in vitro and in vivo

29 September 2017

1 reference

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Photoreceptor IFT complexes containing chaperones, guanylyl cyclase 1 and rhodopsin.

29 September 2017

1 reference

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Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Mitochondrial function and morphology are impaired in parkin-mutant fibroblasts

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

PINK1 controls mitochondrial localization of Parkin through direct phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

The effects of oxidative stress on parkin and other E3 ligases

29 September 2017

1 reference

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Hsp40 molecules that target to the ubiquitin-proteasome system decrease inclusion formation in models of polyglutamine disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Biochemical analysis of Parkinson's disease-causing variants of Parkin, an E3 ubiquitin-protein ligase with monoubiquitylation capacity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Parkin enhances mitochondrial biogenesis in proliferating cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Synphilin-1 and parkin show overlapping expression patterns in human brain and form aggresomes in response to proteasomal inhibition

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

RING finger 1 mutations in Parkin produce altered localization of the protein

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Inactivation of parkin by oxidative stress and C-terminal truncations: a protective role of molecular chaperones

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Inhibition of proteasomal activity causes inclusion formation in neuronal and non-neuronal cells overexpressing Parkin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Structure, function and evolution of DnaJ: conservation and adaptation of chaperone function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy-like inclusions resembling human pale bodies.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Familial-associated mutations differentially disrupt the solubility, localization, binding and ubiquitination properties of parkin.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Neuronal DnaJ proteins HSJ1a and HSJ1b: a role in linking the Hsp70 chaperone machine to the ubiquitin-proteasome system?

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

The C289G and C418R missense mutations cause rapid sequestration of human Parkin into insoluble aggregates

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

The mitochondrial permeability transition initiates autophagy in rat hepatocytes.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3000674

Hsp70 and Hsp40 chaperone activities in the cytoplasm and the nucleus of mammalian cells

27 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/20889486

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

1 reference

https://pubmed.ncbi.nlm.nih.gov/20889486

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDQ428

1 reference

1 reference

1 reference

1 reference