Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy (Q28176737)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

review article

1 reference

title

Apo2L/TRAIL: apoptosis signaling, biology, and potential for cancer therapy (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

author name string

Avi Ashkenazi

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

language of work or name

English

0 references

publication date

1 June 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

Cytokine and Growth Factor Reviews

4 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

volume

14

1 reference

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4 November 2019

page(s)

337-348

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4 November 2019

issue

3-4

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Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family

4 November 2019

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Triggering cell death: the crystal structure of Apo2L/TRAIL in a complex with death receptor 5

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A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

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Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5.

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FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2

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Caspase-10 is recruited to and activated at the native TRAIL and CD95 death-inducing signalling complexes in a FADD-dependent manner but can not functionally substitute caspase-8.

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Distinct stages of cytochrome c release from mitochondria: evidence for a feedback amplification loop linking caspase activation to mitochondrial dysfunction in genotoxic stress induced apoptosis

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Ectopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosis

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Long-term tumor-free survival from treatment with the GFP-TRAIL fusion gene expressed from the hTERT promoter in breast cancer cells.

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Identifiers

DOI

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Consolidated OpenCitations Corpus – April 2017

573459

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12787570%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

573459

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

573459