Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways (Q28182577)

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30 March 2024

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30 March 2024

author name string

Y. Suzuki

1

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30 March 2024

K. Takahashi-Niki

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T. Akagi

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T. Hashikawa

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R. Takahashi

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full work available at URL

30 March 2024

language of work or name

English

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publication date

February 2004

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https://www.nature.com/articles/4401343.pdf

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open access

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http://www.nature.com/articles/4401343.pdf

30 March 2024

file format

Portable Document Format

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DOI

https://api.crossref.org/works/10.1038/SJ.CDD.4401343

http://www.nature.com/articles/4401343

30 March 2024

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DOI

https://api.crossref.org/works/10.1038/SJ.CDD.4401343

Cell Death & Differentiation

30 March 2024

published in

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volume

11

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issue

2

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page(s)

208-16

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cites work

Programmed cell death in animal development

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7 January 2021

Apoptosis in the pathogenesis and treatment of disease

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7 January 2021

Caspases: enemies within

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7 January 2021

An exegesis of IAPs: salvation and surprises from BIR motifs

1 reference

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7 January 2021

IAP family proteins--suppressors of apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

X-linked IAP is a direct inhibitor of cell-death proteases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

A single BIR domain of XIAP sufficient for inhibiting caspases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

IAP proteins: blocking the road to death's door

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

The serine protease Omi/HtrA2 is released from mitochondria during apoptosis. Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Generation and characterization of Smac/DIABLO-deficient mice.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Hid, Rpr and Grim negatively regulate DIAP1 levels through distinct mechanisms

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Regulation of Drosophila IAP1 degradation and apoptosis by reaper and ubcD1.

1 reference

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7 January 2021

Reaper eliminates IAP proteins through stimulated IAP degradation and generalized translational inhibition

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

1 reference

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7 January 2021

Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

CIAP1 and the serine protease HTRA2 are involved in a novel p53-dependent apoptosis pathway in mammals.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Omi/HtrA2 catalytic cleavage of inhibitor of apoptosis (IAP) irreversibly inactivates IAPs and facilitates caspase activity in apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Inhibitor of apoptosis proteins are substrates for the mitochondrial serine protease Omi/HtrA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Molecular determinants of the caspase-promoting activity of Smac/DIABLO and its role in the death receptor pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Ubiquitin fusion technique and its descendants

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

The proapoptotic function of Drosophila Hid is conserved in mammalian cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Caspases induce cytochrome c release from mitochondria by activating cytosolic factors

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Conversion of Bcl-2 to a Bax-like death effector by caspases

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Modulation of cell death by Bcl-XL through caspase interaction

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Movement of Bax from the cytosol to mitochondria during apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Target protease specificity of the viral serpin CrmA. Analysis of five caspases

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Expression, purification, and functional analysis of the human serine protease HtrA2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401343

7 January 2021

Preservation of mitochondrial structure and function after Bid- or Bax-mediated cytochrome c release

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7 January 2021

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