Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan (Q28244634)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25059582%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Depletion of Rictor, an essential protein component of mTORC2, decreases male lifespan (English)

1 reference

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10 March 2020

0 references

1 reference

1

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10 March 2020

Pekka Katajisto

3

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10 March 2020

David M. Sabatini

9

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10 March 2020

5

Omer H Yilmaz

1 reference

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10 March 2020

author name string

Maria M Mihaylova

2

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10 March 2020

Emma L Baar

4

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10 March 2020

Amanda Hutchins

6

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10 March 2020

Yetis Gultekin

7

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10 March 2020

Rachel Gaither

8

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10 March 2020

language of work or name

English

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publication date

25 July 2014

1 reference

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10 March 2020

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10 March 2020

volume

13

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10 March 2020

issue

5

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10 March 2020

page(s)

911-917

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describes a project that uses

10 March 2020

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4172536/fullTextXML

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Hepatic signaling by the mechanistic target of rapamycin complex 2 (mTORC2)

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Haploinsufficiency of akt1 prolongs the lifespan of mice

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TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO

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Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

20 March 2017

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MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

20 March 2017

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Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1

20 March 2017

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

20 March 2017

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

20 March 2017

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20 March 2017

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

20 March 2017

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mTORC1 phosphorylation sites encode their sensitivity to starvation and rapamycin

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Rapamycin extends life and health in C57BL/6 mice

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Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.

29 September 2017

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Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2

29 September 2017

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Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c

29 September 2017

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Chronic activation of mTOR complex 1 is sufficient to cause hepatocellular carcinoma in mice.

29 September 2017

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29 September 2017

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Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue

29 September 2017

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

29 September 2017

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29 September 2017

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29 September 2017

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29 September 2017

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Crossref

https://api.crossref.org/works/10.1111%2FACEL.12256

Sirolimus therapy predisposes to new-onset diabetes mellitus after renal transplantation: a long-term analysis of various treatment regimens

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/25059582

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/ACEL.12256

2 references

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10 March 2020

1 reference

2 references

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10 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25059582%20AND%20SRC:MED&resulttype=core&format=json