Allosteric activation mechanism of the cys-loop receptors (Q28245066)

Europe PubMed Central

title

Allosteric activation mechanism of the cys-loop receptors (English)

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author name string

Yong-chang Chang

1

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Wen Wu

2

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Jian-liang Zhang

3

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Yao Huang

Acta Pharmacologica Sinica

4

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language of work or name

English

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publication date

June 2009

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published in

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volume

30

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issue

6

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page(s)

663-72

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cites work

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Charged Residues in the β2 Subunit Involved in GABAA Receptor Activation

2 June 2018

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Substitutions of the highly conserved M2 leucine create spontaneously opening rho1 gamma-aminobutyric acid receptors.

2 June 2018

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Channel gating governed symmetrically by conserved leucine residues in the M2 domain of nicotinic receptors

2 June 2018

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2 June 2018

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GABAA receptor needs two homologous domains of the beta-subunit for activation by GABA but not by pentobarbital.

2 June 2018

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Amino acids of the Torpedo marmorata acetylcholine receptor alpha subunit labeled by a photoaffinity ligand for the acetylcholine binding site

2 June 2018

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Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor

2 June 2018

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Interaction at End-Plate Receptors between Different Choline Derivatives

2 June 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

Channel opening locks agonist onto the GABAC receptor.

21 January 2018

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Identification of acetylcholine receptor channel-lining residues in the entire M2 segment of the alpha subunit.

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

Mutation of glutamate 155 of the GABAA receptor beta2 subunit produces a spontaneously open channel: a trigger for channel activation.

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

An intersubunit hydrogen bond in the nicotinic acetylcholine receptor that contributes to channel gating.

21 January 2018

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Aromatic residues at position 55 of rat alpha7 nicotinic acetylcholine receptors are critical for maintaining rapid desensitization

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

Site-specific fluorescence reveals distinct structural changes with GABA receptor activation and antagonism

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

Principal pathway coupling agonist binding to channel gating in nicotinic receptors

21 January 2018

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https://api.crossref.org/works/10.1038%2FAPS.2009.51

Charged residues in the alpha1 and beta2 pre-M1 regions involved in GABAA receptor activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FAPS.2009.51

The role of conserved leucines in the M2 domain of the acetylcholine receptor in channel gating.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4002373

Acetylcholine receptor channel imaged in the open state

27 November 2018

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Competitive antagonists bridge the alpha-gamma subunit interface of the acetylcholine receptor through quaternary ammonium-aromatic interactions

21 January 2018

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12 December 2020

Identification of a new component of the agonist binding site of the nicotinic alpha 7 homooligomeric receptor

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12 December 2020

The contributions of aspartyl residues in the acetylcholine receptor gamma and delta subunits to the binding of agonists and competitive antagonists

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12 December 2020

Allosteric receptors after 30 years

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12 December 2020

Acetylcholine receptor binding site contains a disulfide cross-link between adjacent half-cystinyl residues

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12 December 2020

Identification of a novel amino acid alpha-tyrosine 93 within the cholinergic ligands-binding sites of the acetylcholine receptor by photoaffinity labeling. Additional evidence for a three-loop model of the cholinergic ligands-binding sites

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12 December 2020

Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label

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12 December 2020

Evolutionarily conserved allosteric network in the Cys loop family of ligand-gated ion channels revealed by statistical covariance analyses

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12 December 2020

Identifiers

DOI

10.1038/APS.2009.51

1 reference

Dimensions Publication ID

1050540148

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1 reference

1 reference

PubMed publication ID

19444220

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