Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization (Q28248759)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

title

Rheb inhibits C-raf activity and B-raf/C-raf heterodimerization (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

protein heterodimerization activity

25 December 2019

main subject

1 reference

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

author name string

Magdalena Karbowniczek

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

Elizabeth Petri Henske

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

language of work or name

English

0 references

publication date

27 June 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

25 December 2019

number of pages

10

1 reference

based on heuristic

inferred from page(s)

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

volume

281

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

issue

35

1 reference

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25 December 2019

page(s)

25447-25456

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization

25 December 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

The RAF proteins take centre stage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Mutations of the BRAF gene in human cancer

21 January 2018

1 reference

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Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia

21 January 2018

1 reference

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Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Germline KRAS mutations cause Noonan syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome

21 January 2018

1 reference

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Therapy strategies for advanced renal cell carcinoma

21 January 2018

1 reference

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Raf: a strategic target for therapeutic development against cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb is in a high activation state and inhibits B-Raf kinase in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb promotes cell growth as a component of the insulin/TOR signalling network

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

A mammalian protein targeted by G1-arresting rapamycin-receptor complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

TOR, a central controller of cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Critical tyrosine residues regulate the enzymatic and biological activity of Raf-1 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Positive and negative regulation of Raf kinase activity and function by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

B-Raf and Raf-1 are regulated by distinct autoregulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Activation of B-Raf kinase requires phosphorylation of the conserved residues Thr598 and Ser601.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

Aberrant cellular differentiation and migration in renal and pulmonary tuberous sclerosis complex.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M605273200

21 January 2018

Identifiers

DOI

10.1074/JBC.M605273200

2 references

Consolidated OpenCitations Corpus – April 2017

5033487

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16803888%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

5033487

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

2 references

5033487