Interleukin-12 and Th1 immune response in Crohn's disease: pathogenetic relevance and therapeutic implication (Q28265856)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

review article

1 reference

title

Interleukin-12 and Th1 immune response in Crohn's disease: pathogenetic relevance and therapeutic implication (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

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1

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19 December 2019

author name string

Francesco Pallone

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

Giovanni Monteleone

series ordinal

3

1 reference

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19 December 2019

language of work or name

English

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publication date

1 September 2006

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

World Journal of Gastroenterology

19 December 2019

published in

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

volume

12

1 reference

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19 December 2019

issue

35

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19 December 2019

page(s)

5606-5610

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Signalling pathways and molecular interactions of NOD1 and NOD2

19 December 2019

cites work

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Osteopontin/Eta-1 upregulated in Crohn's disease regulates the Th1 immune response

20 March 2017

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Defects in mucosal immunity leading to Crohn's disease

20 March 2017

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Interleukin-21 enhances T-helper cell type I signaling and interferon-gamma production in Crohn's disease

20 March 2017

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20 March 2017

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A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits

20 March 2017

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NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses

20 March 2017

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Interleukin-12 and the regulation of innate resistance and adaptive immunity

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The T-box transcription factor T-bet in immunity and autoimmunity

29 September 2017

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

29 September 2017

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Fontolizumab, a humanised anti-interferon gamma antibody, demonstrates safety and clinical activity in patients with moderate to severe Crohn's disease

29 September 2017

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Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution

29 September 2017

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

29 September 2017

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Potential role for TL1A, the new TNF-family member and potent costimulator of IFN-gamma, in mucosal inflammation

29 September 2017

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Bacterial flagellin is a dominant antigen in Crohn disease.

29 September 2017

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Expression of NOD2 in Paneth cells: a possible link to Crohn's ileitis

29 September 2017

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The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease

29 September 2017

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IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells

29 September 2017

1 reference

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Response of human intestinal lamina propria T lymphocytes to interleukin 12: additive effects of interleukin 15 and 7

29 September 2017

1 reference

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Responses to self and non-self intestinal microflora in health and inflammatory bowel disease

29 September 2017

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T cell-mediated pathology in two models of experimental colitis depends predominantly on the interleukin 12/Signal transducer and activator of transcription (Stat)-4 pathway, but is not conditional on interferon gamma expression by T cells

29 September 2017

1 reference

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Interleukin-12 expression is focally enhanced in the gastric mucosa of pediatric patients with Crohn's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4088159

Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells

29 September 2017

1 reference

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Antibodies to interleukin 12 abrogate established experimental colitis in mice

29 September 2017

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T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.

29 September 2017

1 reference

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Up-regulation of the IL-12 receptor beta 2 chain in Crohn's disease.

2 June 2018

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Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.

2 June 2018

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Bioactive IL-18 expression is up-regulated in Crohn's disease

2 June 2018

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Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease.

2 June 2018

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Disparate CD4+ lamina propria (LP) lymphokine secretion profiles in inflammatory bowel disease. Crohn's disease LP cells manifest increased secretion of IFN-gamma, whereas ulcerative colitis LP cells manifest increased secretion of IL-5.

2 June 2018

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Enhanced expression of matrilysin, collagenase, and stromelysin-1 in gastrointestinal ulcers

2 June 2018

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Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

2 June 2018

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Crossref

https://api.crossref.org/works/10.3748%2FWJG.V12.I35.5606

Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.

21 January 2018

1 reference

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Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4088159

Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells

27 November 2018

1 reference

12 December 2020

Cutting edge: chronic intestinal inflammation in STAT-4 transgenic mice: characterization of disease and adoptive transfer by TNF- plus IFN-gamma-producing CD4+ T cells that respond to bacterial antigens

1 reference

12 December 2020

Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12

1 reference

12 December 2020

Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody

1 reference

12 December 2020

Enhancing Lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury

1 reference

12 December 2020

IL-12/IL-12R system in multiple sclerosis

1 reference

12 December 2020

Identifiers

DOI

10.3748/WJG.V12.I35.5606

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json

19 December 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17007011%20AND%20SRC:MED&resulttype=core&format=json