DNA damage response pathways in tumor suppression and cancer treatment (Q28301859)

Europe PubMed Central

title

DNA damage response pathways in tumor suppression and cancer treatment (English)

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1

Yulong Liang

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author name string

Shiaw-Yih Lin

2

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F Charles Brunicardi

3

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John Goss

4

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Kaiyi Li

ATM activation in normal human tissues and testicular cancer

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language of work or name

English

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publication date

April 2009

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published in

World Journal of Surgery

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volume

33

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issue

4

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page(s)

661-6

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cites work

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Rapid destruction of human Cdc25A in response to DNA damage

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Cell cycle checkpoint signaling through the ATM and ATR kinases

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MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

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Nucleotide excision repair and cancer

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The cellular response to general and programmed DNA double strand breaks

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Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Chemopotentiation of temozolomide, irinotecan, and cisplatin activity by CEP-6800, a poly(ADP-ribose) polymerase inhibitor

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DNA strand break repair and human genetic disease

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Initiating cellular stress responses

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G2 checkpoint abrogators as anticancer drugs

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Mammary tumors in mice conditionally mutant for Brca1 exhibit gross genomic instability and centrosome amplification yet display a recurring distribution of genomic imbalances that is similar to human breast cancer

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12 December 2020

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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12 December 2020

Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

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12 December 2020

Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents

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12 December 2020

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

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12 December 2020

Death signal-induced localization of p53 protein to mitochondria. A potential role in apoptotic signaling

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12 December 2020

The Fanconi road to cancer

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Cell death: critical control points

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p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice

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DNA repair deficiency as a therapeutic target in cancer

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer

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Cancer in xeroderma pigmentosum and related disorders of DNA repair

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Chk1 is an essential kinase that is regulated by Atr and required for the G(2)/M DNA damage checkpoint

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

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Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

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Decision making by p53: life, death and cancer

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

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The concept of synthetic lethality in the context of anticancer therapy

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Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation

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The cellular response to DNA double-strand breaks: defining the sensors and mediators

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Targeting the checkpoint kinases: chemosensitization versus chemoprotection

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Two faces of p53: aging and tumor suppression

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The complexity of p53 stabilization and activation

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The selective poly(ADP-ribose) polymerase-1(2) inhibitor, CEP-8983, increases the sensitivity of chemoresistant tumor cells to temozolomide and irinotecan but does not potentiate myelotoxicity

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ATM signaling and 53BP1.

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Emerging cancer therapeutic opportunities target DNA-repair systems

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Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology

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p53 moves to mitochondria: a turn on the path to apoptosis.

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The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1

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Regulation of G(2)/M events by Cdc25A through phosphorylation-dependent modulation of its stability

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Profiling of UV-induced ATM/ATR signaling pathways.

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12 December 2020

Instability and decay of the primary structure of DNA

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Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25

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Genotoxic and non-genotoxic pathways of p53 induction

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12 December 2020

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

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ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

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12 December 2020

Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis

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12 December 2020

DNA double-strand break repair

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12 December 2020

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

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12 December 2020

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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12 December 2020

Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions

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12 December 2020

Atm-haploinsufficiency enhances susceptibility to carcinogen-induced mammary tumors

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12 December 2020

Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li-Fraumeni syndrome

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12 December 2020

Targeted cancer therapies based on the inhibition of DNA strand break repair

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12 December 2020

The therapeutic potential of poly(ADP-ribose) polymerase inhibitors

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12 December 2020

Mutator pathways unleashed by epigenetic silencing in human cancer

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12 December 2020

DNA helicases, genomic instability, and human genetic disease

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12 December 2020

Running interference: pace picks up on synthetic lethality research

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12 December 2020

Interfaces between the detection, signaling, and repair of DNA damage

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12 December 2020

Genome maintenance mechanisms for preventing cancer

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12 December 2020

Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A.

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12 December 2020

Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes

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12 December 2020