Genotoxic and non-genotoxic pathways of p53 induction (Q34417108)

2 August 2017

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title

Genotoxic and non-genotoxic pathways of p53 induction (English)

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2 August 2017

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O Pluquet

1

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PubMed ID

11675147

2 August 2017

P Hainaut

series ordinal

2

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PubMed ID

11675147

2 August 2017

language of work or name

English

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publication date

1 December 2001

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2 August 2017

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2 August 2017

174

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2 August 2017

1

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2 August 2017

1-15

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Oncogenic forms of p53 inhibit p53-regulated gene expression

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Regulation of the p53 tumor suppressor protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Inhibition of RNA polymerase II as a trigger for the p53 response

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 protein expression is correlated with benzo[a]pyrene-DNA adducts in carcinoma cell lines

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Twenty years of p53 research: structural and functional aspects of the p53 protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

1 reference

7 January 2021

Allosteric activation of latent p53 tetramers

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Regulation of p53 stability by Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Mdm2 promotes the rapid degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

JNK targets p53 ubiquitination and degradation in nonstressed cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Mdm2 association with p53 targets its ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

MDM2--arbiter of p53's destruction

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Amplification of a gene encoding a p53-associated protein in human sarcomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

MDM2 overexpression generates a skin phenotype in both wild type and p53 null mice.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

MEKK1/JNK signaling stabilizes and activates p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Signal transduction by the c-Jun N-terminal kinase (JNK)--from inflammation to development

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Stress-activated kinases regulate protein stability

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Post-translational modifications and activation of p53 by genotoxic stresses

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The dual role model for p53 in maintaining genomic integrity

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

DNA-dependent protein kinase is not required for the p53-dependent response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Synergistic activation of transcription by CBP and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Binding and modulation of p53 by p300/CBP coactivators

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

SUMO-1 modification activates the transcriptional response of p53

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1.

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

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https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

SUMO-1 modification of Mdm2 prevents its self-ubiquitination and increases Mdm2 ability to ubiquitinate p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Defective induction but normal activation and function of p53 in mouse cells lacking poly-ADP-ribose polymerase

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Poly(ADP-ribose) polymerase, a major determinant of early cell response to ionizing radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The INK4a/ARF tumor suppressor: one gene--two products--two pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The CDKN2A (p16) gene and human cancer.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Expression of hypoxia-inducible factor 1: mechanisms and consequences

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The von Hippel-Lindau tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 inhibits hypoxia-inducible factor-stimulated transcription

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Redox regulation of p53 during hypoxia

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 activation in response to microtubule disruption is mediated by integrin-Erk signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Increased p53 phosphorylation after microtubule disruption is mediated in a microtubule inhibitor- and cell-specific manner

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Radiation-induced p53 and p21WAF-1/CIP1 expression in the murine intestinal epithelium: apoptosis and cell cycle arrest.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Enhanced phosphorylation of p53 by ATM in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

A role for ATR in the DNA damage-induced phosphorylation of p53

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

The CDK7-cycH-p36 complex of transcription factor IIH phosphorylates p53, enhancing its sequence-specific DNA binding activity in vitro

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

ERKs and p38 kinase phosphorylate p53 protein at serine 15 in response to UV radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Phosphorylation of human p53 by p38 kinase coordinates N-terminal phosphorylation and apoptosis in response to UV radiation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Regulation of the sequence-specific DNA binding function of p53 by protein kinase C and protein phosphatases

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Phosphorylation of p53 at the casein kinase II site selectively regulates p53-dependent transcriptional repression but not transactivation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Phosphorylation of human p53 on Thr-55.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

DNA damage activates p53 through a phosphorylation-acetylation cascade

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53 accumulation in the organs of low-dose X-ray-irradiated mice

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Nitric oxide (NO) in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD+ content, and p53 accumulation

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Accumulation of p53 protein as a possible predictor of response to adjuvant combination chemotherapy with cyclophosphamide, methotrexate, fluorouracil, and prednisone for breast cancer

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Phorbol esters attenuate the expression of p53 in cells treated with doxorubicin and protect TS-P53/K562 from apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Increased expression of p34cdc2 and its kinase activity in human gastric and colonic carcinomas

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

A p53-dependent mouse spindle checkpoint

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Cytokine-induced modulation of tumor suppressor gene expression in ovarian cancer cells: up-regulation of p53 gene expression and induction of apoptosis by tumor necrosis factor-alpha.

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

Tumor necrosis factor-induced apoptosis stimulates p53 accumulation and p21WAF1 proteolysis in ME-180 cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

p53-dependent induction of WAF1 by heat treatment in human glioblastoma cells

1 reference

https://api.crossref.org/works/10.1016%2FS0304-3835%2801%2900698-X

7 January 2021

10.1016/S0304-3835(01)00698-X

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

11675147