Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases (Q28301962)

The NF-kappa B and I kappa B proteins: new discoveries and insights

Europe PubMed Central

title

Wiring the cell signaling circuitry by the NF-kappa B and JNK1 crosstalk and its applications in human diseases (English)

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J Liu

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A Lin

series ordinal

2

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language of work or name

English

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publication date

14 May 2007

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published in

Oncogene

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volume

26

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issue

22

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page(s)

3267-78

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cites work

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JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

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Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms

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Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit

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A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD

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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

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Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades

20 April 2017

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Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways

20 April 2017

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Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases

20 April 2017

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

20 April 2017

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JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

20 April 2017

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Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2

20 April 2017

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Identification of c-Jun NH2-terminal protein kinase (JNK)-activating kinase 2 as an activator of JNK but not p38

20 April 2017

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Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3

20 April 2017

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

20 April 2017

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Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

20 April 2017

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TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction

20 April 2017

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Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase

20 April 2017

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A mammalian scaffold complex that selectively mediates MAP kinase activation

20 April 2017

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c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms

20 April 2017

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TNF-alpha induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination

20 April 2017

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https://api.crossref.org/works/10.1038/SJ.ONC.1210417

JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD

20 April 2017

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https://api.crossref.org/works/10.1038/SJ.ONC.1210417

Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption

20 April 2017

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https://api.crossref.org/works/10.1038/SJ.ONC.1210417

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Nuclear factor-kappaB in cancer development and progression

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

NF-kappa B: ten years after

20 April 2017

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

A central role for JNK in obesity and insulin resistance

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

NF-kappaB at the crossroads of life and death

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Phorbol esters stimulate the phosphorylation of c-Jun but not v-Jun: regulation by the N-terminal delta domain

20 April 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Elevated JNK activation contributes to the pathogenesis of human brain tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Sequential DNA damage-independent and -dependent activation of NF-kappaB by UV

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Ha-Ras augments c-Jun activity and stimulates phosphorylation of its activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Mutations in the NF-kappaB signaling pathway: implications for human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Role for c-jun N-terminal kinase in treatment-refractory acute myeloid leukemia (AML): signaling to multidrug-efflux and hyperproliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Induction of gadd45beta by NF-kappaB downregulates pro-apoptotic JNK signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Missing pieces in the NF-kappaB puzzle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Activation of the JNK pathway is important for cardiomyocyte death in response to simulated ischemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

DNA damaging agents induce expression of Fas ligand and subsequent apoptosis in T lymphocytes via the activation of NF-kappa B and AP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

The regulation of AP-1 activity by mitogen-activated protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

CK2 Is a C-Terminal IκB Kinase Responsible for NF-κB Activation during the UV Response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Daxx is required for stress-induced cell death and JNK activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Impaired ionizing radiation-induced activation of a nuclear signal essential for phosphorylation of c-Jun by dually phosphorylated c-Jun amino-terminal kinases in ataxia telangiectasia fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Ionizing radiation and short wavelength UV activate NF-kappaB through two distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Severe liver degeneration in mice lacking the IkappaB kinase 2 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Activation of the JNK signaling pathway: breaking the brake on apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

NF-kappaB in cancer: a marked target

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Activation of SAPK/JNK by TNF receptor 1 through a noncytotoxic TRAF2-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

The JNK/c-Jun cascade and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Signal-dependent and -independent degradation of free and NF-kappa B-bound IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Targeting of TAK1 by the NF-kappa B protein Relish regulates the JNK-mediated immune response in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Phosphorylation of c-jun mediated by MAP kinases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

TNFα as Therapeutic Target: New Drugs, More Applications

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

The mammalian UV response: c-Jun induction is required for exit from p53-imposed growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Embryonic lethality, liver degeneration, and impaired NF-kappa B activation in IKK-beta-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Inhibition of JNK activation through NF-kappaB target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

JNK mediates hepatic ischemia reperfusion injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Gene transfer of the JNK interacting protein-1 protects dopaminergic neurons in the MPTP model of Parkinson's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Ferritin Heavy Chain Upregulation by NF-κB Inhibits TNFα-Induced Apoptosis by Suppressing Reactive Oxygen Species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Cell survival and a Gadd45-factor deficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

RACK1 mediates activation of JNK by protein kinase C [corrected].

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

IKKβ Is Required for Prevention of Apoptosis Mediated by Cell-Bound but Not by Circulating TNFα

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

Structure, regulation and function of NF-kappa B

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

NF-kappa B: a lesson in family values

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021

The JNKK2-JNK1 fusion protein acts as a constitutively active c-Jun kinase that stimulates c-Jun transcription activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1210417

7 January 2021