Lifespan extension and cancer prevention in HER-2/neu transgenic mice treated with low intermittent doses of rapamycin (Q28307873)

1

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Vladimir N Anisimov

2

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Mark A Zabezhinski

3

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Anna V Semenchenko

4

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Margarita L Tyndyk

5

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Maria N Yurova

Cancer Biology and Therapy

6

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language of work or name

English

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publication date

May 2014

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published in

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volume

15

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issue

5

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page(s)

586-92

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cites work

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Rapamycin extends life and health in C57BL/6 mice

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Rapamycin extends life span of Rb1+/- mice by inhibiting neuroendocrine tumors

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Mechanistic or mammalian target of rapamycin (mTOR) may determine robustness in young male mice at the cost of accelerated aging

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Rapamycin extends lifespan and delays tumorigenesis in heterozygous p53+/- mice

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New nanoformulation of rapamycin Rapatar extends lifespan in homozygous p53-/- mice by delaying carcinogenesis

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mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

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Rapamycin reverses elevated mTORC1 signaling in lamin A/C-deficient mice, rescues cardiac and skeletal muscle function, and extends survival.

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Once again on rapamycin-induced insulin resistance and longevity: despite of or owing to.

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Rapamycin slows aging in mice

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If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

29 September 2017

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Increasing healthy lifespan by suppressing aging in our lifetime: preliminary proposal

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Rapamycin extends maximal lifespan in cancer-prone mice

29 September 2017

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29 September 2017

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Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice

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Sirolimus and secondary skin-cancer prevention in kidney transplantation.

21 January 2018

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Exploiting the mTOR paradox for disease prevention

21 January 2018

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Identification of a highly effective rapamycin schedule that markedly reduces the size, multiplicity, and phenotypic progression of tobacco carcinogen-induced murine lung tumors.

21 January 2018

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Metformin decelerates aging and development of mammary tumors in HER-2/neu transgenic mice

21 January 2018

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Metformin slows down aging and extends life span of female SHR mice.

21 January 2018

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21 January 2018

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Metformin and rapamycin are master-keys for understanding the relationship between cell senescent, aging and cancer

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24556924

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Methods of testing pharmacological drugs effects on aging and life span in mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24556924

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.4161/CBT.28164

1 reference

1 reference

1 reference

PubMed publication ID

24556924

1 reference