Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis (Q28385517)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24636985%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis (English)

1 reference

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10 March 2020

0 references

1

1 reference

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10 March 2020

Fei Zhao

2

1 reference

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10 March 2020

5

Naoko Yagishita

1 reference

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10 March 2020

author name string

Beixue Gao

3

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10 March 2020

Can Tan

4

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10 March 2020

Toshihiro Nakajima

6

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10 March 2020

Pak K Wong

7

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10 March 2020

Eli Chapman

8

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10 March 2020

Deyu Fang

9

1 reference

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10 March 2020

Donna D Zhang

10

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10 March 2020

language of work or name

English

0 references

publication date

17 March 2014

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10 March 2020

1 reference

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10 March 2020

volume

28

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10 March 2020

issue

7

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10 March 2020

page(s)

708-722

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Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2

10 March 2020

cites work

1 reference

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Small molecule modulators of Keap1-Nrf2-ARE pathway as potential preventive and therapeutic agents

20 March 2017

1 reference

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The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

20 March 2017

1 reference

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Dual regulation of the transcriptional activity of Nrf1 by β-TrCP- and Hrd1-dependent degradation mechanisms

20 March 2017

1 reference

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Proteasomal degradation is transcriptionally controlled by TCF11 via an ERAD-dependent feedback loop

20 March 2017

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Stress-activated cap'n'collar transcription factors in aging and human disease

20 March 2017

1 reference

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Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response

20 March 2017

1 reference

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Synoviolin promotes IRE1 ubiquitination and degradation in synovial fibroblasts from mice with collagen-induced arthritis

20 March 2017

1 reference

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Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2

20 March 2017

1 reference

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Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'

20 March 2017

1 reference

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Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

20 March 2017

1 reference

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Negative regulation of the Nrf1 transcription factor by its N-terminal domain is independent of Keap1: Nrf1, but not Nrf2, is targeted to the endoplasmic reticulum

20 March 2017

1 reference

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Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

20 March 2017

1 reference

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Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2

20 March 2017

1 reference

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Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy

20 March 2017

1 reference

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IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

20 March 2017

1 reference

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XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor

20 March 2017

1 reference

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Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation

20 March 2017

1 reference

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

20 March 2017

1 reference

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Toll-like receptor-mediated IRE1α activation as a therapeutic target for inflammatory arthritis

20 March 2017

1 reference

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Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis

20 March 2017

1 reference

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E3 ubiquitin ligase synoviolin is involved in liver fibrogenesis

20 March 2017

1 reference

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Essential role of synoviolin in embryogenesis

20 March 2017

1 reference

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Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway

20 March 2017

1 reference

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Mechanisms of fibrosis: therapeutic translation for fibrotic disease

7 April 2017

1 reference

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

7 April 2017

1 reference

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The emerging role of the Nrf2-Keap1 signaling pathway in cancer

7 April 2017

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Alcohol cirrhosis alters nuclear receptor and drug transporter expression in human liver

29 September 2017

1 reference

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The protective effect of glycyrrhetinic acid on carbon tetrachloride-induced chronic liver fibrosis in mice via upregulation of Nrf2.

29 September 2017

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RING-finger type E3 ubiquitin ligase inhibitors as novel candidates for the treatment of rheumatoid arthritis

29 September 2017

1 reference

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Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity.

29 September 2017

1 reference

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Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/β-TrCP axis

29 September 2017

1 reference

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Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy

29 September 2017

1 reference

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SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner.

29 September 2017

1 reference

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Pathogenesis of liver fibrosis

29 September 2017

1 reference

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In vivo cellular adaptation to ER stress: survival strategies with double-edged consequences

29 September 2017

1 reference

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Nrf2 protects against As(III)-induced damage in mouse liver and bladder

29 September 2017

1 reference

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Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4015486

Human HRD1 promoter carries a functional unfolded protein response element to which XBP1 but not ATF6 directly binds

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4015486

Toxicogenomics of endoplasmic reticulum stress inducer tunicamycin in the small intestine and liver of Nrf2 knockout and C57BL/6J mice

29 September 2017

1 reference

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Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4015486

Hepatic fibrosis: molecular mechanisms and drug targets

29 September 2017

1 reference

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The ubiquitin ligase synoviolin up-regulates amyloid β production by targeting a negative regulator of γ-secretase, Rer1, for degradation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4015486

Phenylbutyric acid protects against carbon tetrachloride-induced hepatic fibrogenesis in mice

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4015486

Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease.

27 November 2018

1 reference

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Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis

27 November 2018

1 reference

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Reversibility of fibrosis, inflammation, and endoplasmic reticulum stress in the liver of rats fed a methionine-choline-deficient diet

27 November 2018

1 reference

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Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a "tethering" mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

27 November 2018

1 reference

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Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24636985

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1101/GAD.238246.114

2 references

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10 March 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24636985%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24636985%20AND%20SRC:MED&resulttype=core&format=json