A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process (Q28390796)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612826%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

title

A strategically designed small molecule attacks alpha-ketoglutarate dehydrogenase in tumor cells through a redox process (English)

1 reference

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10 March 2020

5

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10 March 2020

author name string

Shawn D Stuart

1

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10 March 2020

Alexandra Schauble

2

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10 March 2020

Sunita Gupta

3

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10 March 2020

Adam D Kennedy

4

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10 March 2020

Paul M Bingham

6

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10 March 2020

Zuzana Zachar

7

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10 March 2020

language of work or name

English

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publication date

10 March 2014

1 reference

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10 March 2020

2 references

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10 March 2020

volume

2

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10 March 2020

issue

1

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10 March 2020

page(s)

4

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An update on the role of mitochondrial α-ketoglutarate dehydrogenase in oxidative stress

10 March 2020

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Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

7 April 2017

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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence.

29 September 2017

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Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death

29 September 2017

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Inhibition of pyruvate kinase M2 by reactive oxygen species contributes to cellular antioxidant responses

29 September 2017

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Targeting cancer metabolism: a therapeutic window opens

29 September 2017

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Non-redox-active lipoate derivates disrupt cancer cell mitochondrial metabolism and are potent anticancer agents in vivo

29 September 2017

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α-Ketoglutarate dehydrogenase: a mitochondrial redox sensor

29 September 2017

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Glycolytic cancer associated fibroblasts promote breast cancer tumor growth, without a measurable increase in angiogenesis: evidence for stromal-epithelial metabolic coupling

29 September 2017

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Oxidative inactivation of mitochondrial aconitase results in iron and H2O2-mediated neurotoxicity in rat primary mesencephalic cultures

29 September 2017

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Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

29 September 2017

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Reactive oxygen species-dependent signaling regulates cancer

29 September 2017

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29 September 2017

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Redox signaling and cancer: the role of "labile" iron

29 September 2017

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Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid

29 September 2017

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29 September 2017

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21 January 2018

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21 January 2018

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21 January 2018

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27 November 2018

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Tumor-specific pyruvate kinase isoenzyme M2 involved in biochemical strategy of energy generation in neoplastic cells

27 November 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/24612826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured filroblasts

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24612826

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/2049-3002-2-4

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612826%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

10 March 2020

1013454984

0 references

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612826%20AND%20SRC:MED&resulttype=core&format=json

10 March 2020

PubMed publication ID

24612826

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24612826%20AND%20SRC:MED&resulttype=core&format=json