mechanistic target of rapamycin kinase (Q285613)

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mammalian protein found in Homo sapiens
  • FKBP12-rapamycin complex-associated protein
  • FK506-binding protein 12-rapamycin complex-associated protein 1
  • FK506 binding protein 12-rapamycin associated protein 2
  • serine/threonine-protein kinase mTOR
  • rapamycin and FKBP12 target 1
  • rapamycin associated protein FRAP2
  • mechanistic target of rapamycin (serine/threonine kinase)
  • Mechanistic target of rapamycin
  • mammalian target of rapamycin
  • FKBP12-rapamycin complex-associated protein 1
  • FKBP-rapamycin associated protein
  • rapamycin target protein 1
  • MTOR
edit
Language Label Description Also known as
English
mechanistic target of rapamycin kinase
mammalian protein found in Homo sapiens
  • FKBP12-rapamycin complex-associated protein
  • FK506-binding protein 12-rapamycin complex-associated protein 1
  • FK506 binding protein 12-rapamycin associated protein 2
  • serine/threonine-protein kinase mTOR
  • rapamycin and FKBP12 target 1
  • rapamycin associated protein FRAP2
  • mechanistic target of rapamycin (serine/threonine kinase)
  • Mechanistic target of rapamycin
  • mammalian target of rapamycin
  • FKBP12-rapamycin complex-associated protein 1
  • FKBP-rapamycin associated protein
  • rapamycin target protein 1
  • MTOR

Statements

part of
molecular function
kinase activity
determination method or standard
IDA
TAS
IEA
6 references
retrieved
1 January 2018
stated in
Characterization of ubiquilin 1, an mTOR-interacting protein
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
protein serine/threonine kinase activity
determination method or standard
EXP
IDA
TAS
IEA
7 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
TAS
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
31 October 2017
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
31 October 2017
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
31 October 2017
stated in
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
EXP
protein binding
determination method or standard
IPI
50 references
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
The Potential Role of BRCA1-Associated ATM Activator-1 (BRAT1) in Regulation of mTOR
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Phospholipase D1 is an effector of Rheb in the mTOR pathway.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Visualization of biochemical networks in living cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Architecture of human mTOR complex 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Huntingtin functions as a scaffold for selective macroautophagy
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
A system for quantifying dynamic protein interactions defines a role for Herceptin in modulating ErbB2 interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
The PtdIns3-phosphatase MTMR3 interacts with mTORC1 and suppresses its activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Direct control of mitochondrial function by mTOR.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Refined structure of the FKBP12-rapamycin-FRB ternary complex at 2.2 A resolution
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Ribavirin enhances interferon signaling via stimulation of mTOR and p53 activities
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Probing cellular protein complexes using single-molecule pull-down
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTORC2 phosphorylates protein kinase Cζ to regulate its stability and activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Leucyl-tRNA synthetase is an intracellular leucine sensor for the mTORC1-signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Targeting PDK1 with dichloroacetophenone to inhibit acute myeloid leukemia (AML) cell growth
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Rab1A is an mTORC1 activator and a colorectal oncogene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Activation of mTORC2 by association with the ribosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTOR kinase structure, mechanism and regulation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
PIH1D1 interacts with mTOR complex 1 and enhances ribosome RNA transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Glycerolipid signals alter mTOR complex 2 (mTORC2) to diminish insulin signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Network organization of the human autophagy system
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Protein tag-mediated conjugation of oligonucleotides to recombinant affinity binders for proximity ligation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
retrieved
1 January 2018
stated in
The target of rapamycin complex 2 controls dendritic tiling of Drosophila sensory neurons through the Tricornered kinase signalling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IPI
protein serine/threonine kinase activity
determination method or standard
EXP
IBA
IDA
IEA
TAS
8 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IBA
retrieved
1 January 2018
stated in
mTOR is essential for the proteotoxic stress response, HSF1 activation and heat shock protein synthesis
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
EXP
cell component
TORC1 complex
determination method or standard
IDA
IEA
IMP
6 references
retrieved
31 October 2017
stated in
DAP1, a novel substrate of mTOR, negatively regulates autophagy
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
31 October 2017
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
31 October 2017
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
31 October 2017
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
31 October 2017
stated in
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
31 October 2017
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P42345&geneProductId=UniProtKB:P42345
determination method or standard
IDA
TORC1 complex
determination method or standard
IBA
IDA
IEA
IMP
7 references
retrieved
1 January 2018
stated in
DAP1, a novel substrate of mTOR, negatively regulates autophagy
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
retrieved
1 January 2018
stated in
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
GOA
curator
WormBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IBA
biological process
TOR signaling
determination method or standard
IEA
IMP
NAS
7 references
retrieved
1 January 2018
stated in
IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway
GOA
curator
Parkinsons Disease Gene Ontology Initiative
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
NAS
retrieved
1 January 2018
stated in
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration.
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb.
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
GOA
curator
UniProt
UniProt protein ID
P42345
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IMP
retrieved
1 January 2018
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42345
determination method or standard
IEA
physically interacts with
Gene Atlas image
PBB GE FRAP1 202288 at fs.png
732 × 530; 11 KB
0 references

Identifiers

Microsoft Academic ID
2777949483
0 references
2910776440
0 references
PDB structure ID
 
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                  Retrieved from "https://www.wikidata.org/w/index.php?title=Q285613&oldid=2142718113"