Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis (Q28582648)

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English	Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis	scientific journal article

Statements

scholarly article

1 reference

31 January 2017

Calcium-independent phospholipase A2 (iPLA2 beta)-mediated ceramide generation plays a key role in the cross-talk between the endoplasmic reticulum (ER) and mitochondria during ER stress-induced insulin-secreting cell apoptosis (English)

1 reference

31 January 2017

endoplasmic reticulum

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apoptotic process

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1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

author name string

Xiaoyong Lei

1

1 reference

31 January 2017

Sheng Zhang

2

1 reference

31 January 2017

Alan Bohrer

3

1 reference

31 January 2017

Sasanka Ramanadham

4

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31 January 2017

language of work or name

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publication date

12 December 2008

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31 January 2017

Journal of Biological Chemistry

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31 January 2017

283

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31 January 2017

34819–34832

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31 January 2017

50

1 reference

31 January 2017

Ceramide forms channels in mitochondrial outer membranes at physiologically relevant concentrations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2596401

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WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic beta-cells

1 reference

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Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

1 reference

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The expression and function of a group VIA calcium-independent phospholipase A2 (iPLA2beta) in beta-cells

1 reference

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Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress

1 reference

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Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

1 reference

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

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WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

1 reference

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Structural basis of IAP recognition by Smac/DIABLO

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EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome

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cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37)

1 reference

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Phospholipases A2

1 reference

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Caspases: the executioners of apoptosis

1 reference

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Pancreatic islets express a Ca2+-independent phospholipase A2 enzyme that contains a repeated structural motif homologous to the integral membrane protein binding domain of ankyrin

1 reference

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Mass spectrometric identification and quantitation of arachidonate-containing phospholipids in pancreatic islets: prominence of plasmenylethanolamine molecular species

1 reference

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The pathophysiology of mitochondrial cell death

1 reference

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Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

1 reference

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

1 reference

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Group VI phospholipases A2: homeostatic phospholipases with significant potential as targets for novel therapeutics

1 reference

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The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.

1 reference

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1 reference

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ER stress-induced apoptosis and caspase-12 activation occurs downstream of mitochondrial apoptosis involving Apaf-1.

1 reference

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Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario

1 reference

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1 reference

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Mechanisms of cytochrome c release from mitochondria

1 reference

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WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells

1 reference

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Mitochondrial ceramide and the induction of apoptosis

1 reference

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Endoplasmic reticulum quality control and apoptosis

1 reference

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Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells

1 reference

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Biologically active sphingolipids in cancer pathogenesis and treatment

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1 reference

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Apoptosis of insulin-secreting cells induced by endoplasmic reticulum stress is amplified by overexpression of group VIA calcium-independent phospholipase A2 (iPLA2 beta) and suppressed by inhibition of iPLA2 beta

1 reference

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Impact of Endoplasmic Reticulum Stress Pathway on Pancreatic β-Cells and Diabetes Mellitus

1 reference

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The endoplasmic reticulum: a multifunctional signaling organelle

1 reference

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Translational control in the endoplasmic reticulum stress response

1 reference

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Ceramide: second messenger or modulator of membrane structure and dynamics?

1 reference

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Endoplasmic reticulum stress-mediated apoptosis in pancreatic beta-cells

1 reference

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Biochemical identification of a neutral sphingomyelinase 1 (NSM1)-like enzyme as the major NSM activity in the DT40 B-cell line: absence of a role in the apoptotic response to endoplasmic reticulum stress

1 reference

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Na/Ca exchanger overexpression induces endoplasmic reticulum-related apoptosis and caspase-12 activation in insulin-releasing BRIN-BD11 cells

1 reference

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Calcium and oxidative stress: from cell signaling to cell death

1 reference

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beta-Cell death during progression to diabetes

1 reference

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Nitric oxide-induced apoptosis in pancreatic beta cells is mediated by the endoplasmic reticulum stress pathway

1 reference

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

1 reference

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The machinery of local Ca2+ signalling between sarco-endoplasmic reticulum and mitochondria

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Mitochondria and calcium: from cell signalling to cell death

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1 reference

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Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM.

1 reference

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Intersectin-1s Regulates the Mitochondrial Apoptotic Pathway in Endothelial Cells

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1 reference

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Ceramide activates a mitochondrial p38 mitogen-activated protein kinase: a potential mechanism for loss of mitochondrial transmembrane potential and apoptosis

1 reference

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1 reference

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Involvement of ceramide in the mechanism of Cr(VI)-induced apoptosis of CHO cells

1 reference

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Mitochondrial ceramide increases in UV-irradiated HeLa cells and is mainly derived from hydrolysis of sphingomyelin

1 reference

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Palmitate inhibition of insulin gene expression is mediated at the transcriptional level via ceramide synthesis

1 reference

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1 reference

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1 reference

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1 reference

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Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis

1 reference

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

12 December 2020

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inferred from PubMed ID database lookup

Insulin-dependent diabetes mellitus

1 reference

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

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inferred from PubMed ID database lookup

Structural determination of sphingomyelin by tandem mass spectrometry with electrospray ionization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

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12 December 2020

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inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

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inferred from PubMed ID database lookup

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1 reference

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inferred from PubMed ID database lookup

4-HPR-mediated leukemia cell cytotoxicity is triggered by ceramide-induced mitochondrial oxidative stress and is regulated downstream by Bcl-2

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

12 December 2020

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inferred from PubMed ID database lookup

Mass spectrometric evidence that agents that cause loss of Ca2+ from intracellular compartments induce hydrolysis of arachidonic acid from pancreatic islet membrane phospholipids by a mechanism that does not require a rise in cytosolic Ca2+ concentr

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

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based on heuristic

inferred from PubMed ID database lookup

Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/18936091

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1 reference

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M807409200

1 reference

31 January 2017

0 references

1 reference

31 January 2017

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