Presenilin/gamma-secretase-dependent processing of beta-amyloid precursor protein regulates EGF receptor expression (Q28585864)

Amyloid beta (A4) precursor protein

1 reference

Presenilin 1

1 reference

Amyloid beta (A4) precursor-like protein 2

1 reference

author name string

Yun-wu Zhang

1

1 reference

31 January 2017

Ruishan Wang

2

1 reference

31 January 2017

Qiang Liu

3

1 reference

31 January 2017

Han Zhang

4

1 reference

31 January 2017

Francesca-Fang Liao

5

1 reference

31 January 2017

Huaxi Xu

Proceedings of the National Academy of Sciences of the United States of America

6

1 reference

31 January 2017

language of work or name

English

0 references

publication date

19 June 2007

1 reference

31 January 2017

1 reference

31 January 2017

104

1 reference

31 January 2017

25

1 reference

31 January 2017

10613–10618

1 reference

31 January 2017

The amyloid precursor protein: beyond amyloid

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

APH-1a is the principal mammalian APH-1 isoform present in gamma-secretase complexes during embryonic development

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Association of gamma-secretase with lipid rafts in post-Golgi and endosome membranes

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Myeloproliferative disease in mice with reduced presenilin gene dosage: effect of gamma-secretase blockage

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Nicastrin Is Required for Assembly of Presenilin/γ-Secretase Complexes to Mediate Notch Signaling and for Processing and Trafficking of β-Amyloid Precursor Protein in Mammals

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Loss of presenilin 1 is associated with enhanced beta-catenin signaling and skin tumorigenesis

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Mice lacking both presenilin genes exhibit early embryonic patterning defects

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Skeletal and CNS defects in Presenilin-1-deficient mice

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Endoproteolysis of presenilin 1 and accumulation of processed derivatives in vivo

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

EGF-ERBB signalling: towards the systems level

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Targeting epidermal growth factor receptor signaling in the treatment of head and neck cancer

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Pathological and physiological functions of presenilins

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Regulated intramembrane proteolysis of amyloid precursor protein and regulation of expression of putative target genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Common side effects of anti-EGFR therapy: acneform rash

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Activation of GSK-3 and phosphorylation of CRMP2 in transgenic mice expressing APP intracellular domain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Transcription regulation by the adaptor protein Fe65 and the nucleosome assembly factor SET.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

The gamma-secretase complex: machinery for intramembrane proteolysis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

A common enzyme connects notch signaling and Alzheimer's disease

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

The EGF receptor - an essential regulator of multiple epidermal functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Cellular and molecular basis of beta-amyloid precursor protein metabolism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Generation of Alzheimer beta-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

Notch1 is essential for postimplantation development in mice.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1888796

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

3 June 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0703903104

Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0703903104

Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Abeta1-42/43 expression.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1073%2FPNAS.0703903104

Metabolism of the "Swedish" amyloid precursor protein variant in Madin-Darby canine kidney cells

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17556541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17556541

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0703903104

1 reference

3896001

ADS bibcode

2007PNAS..10410613Z

0 references

3896001

1 reference

1 reference

1 reference