PIASy-mediated sumoylation of SREBP1c regulates hepatic lipid metabolism upon fasting signaling (Q28587145)

Small ubiquitin-like modifier 1

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

1 reference

2

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12 June 2020

Sekyu Choi

5

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12 June 2020

Jae Bum Kim

7

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12 June 2020

author name string

Gha Young Lee

1

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31 January 2017

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12 June 2020

Jae Ho Lee

3

2 references

31 January 2017

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12 June 2020

Jin Young Huh

4

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31 January 2017

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12 June 2020

Jongkyeong Chung

6

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31 January 2017

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Molecular and Cellular Biology

12 June 2020

language of work or name

English

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publication date

1 March 2014

1 reference

31 January 2017

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31 January 2017

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12 June 2020

volume

34

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31 January 2017

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12 June 2020

page(s)

926-938

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12 June 2020

issue

6

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31 January 2017

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Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1

12 June 2020

cites work

1 reference

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SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism

17 March 2017

1 reference

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SUMOylation of human peroxisome proliferator-activated receptor alpha inhibits its trans-activity through the recruitment of the nuclear corepressor NCoR

17 March 2017

1 reference

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Modification in reverse: the SUMO proteases

17 March 2017

1 reference

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Chromatin remodeling complex interacts with ADD1/SREBP1c to mediate insulin-dependent regulation of gene expression

17 March 2017

1 reference

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Regulation of gene-activation pathways by PIAS proteins in the immune system

17 March 2017

1 reference

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SUMO: a history of modification

17 March 2017

2 references

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17 March 2017

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SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

6 April 2017

1 reference

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Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes

17 March 2017

1 reference

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A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3

17 March 2017

1 reference

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Sumoylation of Mdm2 by protein inhibitor of activated STAT (PIAS) and RanBP2 enzymes

17 March 2017

1 reference

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Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice

17 March 2017

1 reference

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Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

17 March 2017

1 reference

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A proteolytic pathway that controls the cholesterol content of membranes, cells, and blood

17 March 2017

1 reference

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ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

17 March 2017

1 reference

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A simplified system for generating recombinant adenoviruses

17 March 2017

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Specific inhibition of Stat3 signal transduction by PIAS3

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor

17 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Sterol-regulated release of SREBP-2 from cell membranes requires two sequential cleavages, one within a transmembrane segment

17 March 2017

1 reference

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SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene

17 March 2017

1 reference

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SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis

17 March 2017

1 reference

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

17 March 2017

1 reference

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SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targeting

7 April 2017

1 reference

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Sumoylation of AMPKβ2 subunit enhances AMP-activated protein kinase activity.

7 April 2017

1 reference

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Phosphorylation and recruitment of BAF60c in chromatin remodeling for lipogenesis in response to insulin

29 September 2017

1 reference

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SREBPs: metabolic integrators in physiology and metabolism

29 September 2017

1 reference

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Postprandial hepatic lipid metabolism requires signaling through Akt2 independent of the transcription factors FoxA2, FoxO1, and SREBP1c

29 September 2017

1 reference

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Inhibitory effect of LXR activation on cell proliferation and cell cycle progression through lipogenic activity

29 September 2017

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Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP.

29 September 2017

1 reference

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mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.

29 September 2017

1 reference

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A molecular basis for phosphorylation-dependent SUMO conjugation by the E2 UBC9.

29 September 2017

1 reference

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GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

29 September 2017

1 reference

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Growth factor-induced phosphorylation of sterol regulatory element-binding proteins inhibits sumoylation, thereby stimulating the expression of their target genes, low density lipoprotein uptake, and lipid synthesis

29 September 2017

1 reference

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SUMO-specific proteases: a twist in the tail

29 September 2017

1 reference

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A recurrent phospho-sumoyl switch in transcriptional repression and beyond

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Sterol regulatory element-binding protein 1 is negatively modulated by PKA phosphorylation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Deubiquitinating enzymes as cellular regulators

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Coactivator-dependent acetylation stabilizes members of the SREBP family of transcription factors.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Sterol regulatory element-binding proteins are negatively regulated through SUMO-1 modification independent of the ubiquitin/26 S proteasome pathway

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Nutritional and insulin regulation of fatty acid synthetase and leptin gene expression through ADD1/SREBP1.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

ADD1: a novel helix-loop-helix transcription factor associated with adipocyte determination and differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Insulin effects on sterol regulatory-element-binding protein-1c (SREBP-1c) transcriptional activity in rat hepatocytes.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

ADD1/SREBP1 promotes adipocyte differentiation and gene expression linked to fatty acid metabolism

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

A SUMOylation-dependent pathway regulates SIRT1 transcription and lung cancer metastasis.

3 June 2018

1 reference

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Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

Direct demonstration of rapid degradation of nuclear sterol regulatory element-binding proteins by the ubiquitin-proteasome pathway

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3958042

c-Jun and p53 Activity Is Modulated by SUMO-1 Modification

27 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24379443

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1128/MCB.01166-13

2 references

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12 June 2020

1 reference

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12 June 2020

2 references

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