Presenilins regulate alphabeta T cell development by modulating TCR signaling (Q28587555)

Journal of Experimental Medicine

GOA release 2020-03-11

1

Karen Laky

1 reference

31 January 2017

B. J. Fowlkes

2

1 reference

31 January 2017

language of work or name

English

0 references

publication date

3 September 2007

1 reference

31 January 2017

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31 January 2017

204

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31 January 2017

9

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31 January 2017

2115–2129

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31 January 2017

The notch regulator MAML1 interacts with p53 and functions as a coactivator

1 reference

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

17 March 2017

1 reference

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AP-1 subunits: quarrel and harmony among siblings

17 March 2017

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The Anti-apoptotic Effect of Notch-1 Requires p56 -dependent, Akt/PKB-mediated Signaling in T Cells

17 March 2017

1 reference

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Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces

17 March 2017

1 reference

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Notch1 regulates maturation of CD4+ and CD8+ thymocytes by modulating TCR signal strength

17 March 2017

1 reference

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Mice lacking both presenilin genes exhibit early embryonic patterning defects

17 March 2017

1 reference

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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

17 March 2017

1 reference

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Expression pattern of notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand-receptor interactions in intrathymic T cell development

17 March 2017

1 reference

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Activated notch inhibits myogenic activity of the MADS-Box transcription factor myocyte enhancer factor 2C

17 March 2017

1 reference

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Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm

17 March 2017

1 reference

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T cell leukemia-associated human Notch/translocation-associated Notch homologue has I kappa B-like activity and physically interacts with nuclear factor-kappa B proteins in T cells

17 March 2017

1 reference

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Notch signalling: a simple pathway becomes complex

17 March 2017

1 reference

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Notch signaling is essential for vascular morphogenesis in mice

7 April 2017

1 reference

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Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.

7 April 2017

1 reference

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

29 September 2017

1 reference

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The duration of ERK1/2 activity determines the activation of c-Fos and Fra-1 and the composition and quantitative transcriptional output of AP-1.

29 September 2017

1 reference

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The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

29 September 2017

1 reference

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Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.

29 September 2017

1 reference

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TCR and Notch signaling in CD4 and CD8 T-cell development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

LIN-12/Notch activation leads to microRNA-mediated down-regulation of Vav in C. elegans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Notch signaling is an important regulator of type 2 immunity.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

The love-hate relationship between Ras and Notch.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions

29 September 2017

1 reference

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CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Notch 1 signaling regulates peripheral T cell activation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Activated Notch2 potentiates CD8 lineage maturation and promotes the selective development of B1 B cells.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

The role of Tec family kinases in T cell development and function

29 September 2017

1 reference

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Specific down-modulation of Notch1 signaling in cervical cancer cells is required for sustained HPV-E6/E7 expression and late steps of malignant transformation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

CSL-independent Notch signalling: a checkpoint in cell fate decisions during development?

29 September 2017

1 reference

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T-cell development and the CD4-CD8 lineage decision

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Involvement of a proline-rich motif and RING-H2 finger of Deltex in the regulation of Notch signaling

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

The notch intracellular domain can function as a coactivator for LEF-1

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Presenilin-dependent gamma-secretase activity modulates thymocyte development

29 September 2017

1 reference

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Notch pathway: making sense of suppressor of hairless

29 September 2017

1 reference

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Tec family kinases modulate thresholds for thymocyte development and selection

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Notch1 signaling promotes the maturation of CD4 and CD8 SP thymocytes

29 September 2017

1 reference

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Constitutive activation of NF-kappaB and T-cell leukemia/lymphoma in Notch3 transgenic mice

29 September 2017

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Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

29 September 2017

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Cutting edge: protective effects of notch-1 on TCR-induced apoptosis.

29 September 2017

1 reference

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Correlating notch signaling with thymocyte maturation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

CD5 expression is developmentally regulated by T cell receptor (TCR) signals and TCR avidity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Selective events in T cell development

29 September 2017

1 reference

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In vivo and in vitro clonal deletion of double-positive thymocytes

29 September 2017

1 reference

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Fine tuning of TCR signaling by CD5.

29 September 2017

1 reference

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Highly efficient selection of CD4 and CD8 lineage thymocytes supports an instructive model of lineage commitment

3 June 2018

1 reference

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Negative regulation of CD4 lineage development and responses by CD5.

3 June 2018

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Itk and Fyn make independent contributions to T cell activation

3 June 2018

1 reference

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An activated form of Notch influences the choice between CD4 and CD8 T cell lineages

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Inactivation of Notch1 impairs VDJbeta rearrangement and allows pre-TCR-independent survival of early alpha beta Lineage Thymocytes.

3 June 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Notch activity influences the alphabeta versus gammadelta T cell lineage decision

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Regulation of alphabeta/gammadelta T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Transgenic expression of numb inhibits notch signaling in immature thymocytes but does not alter T cell fate specification.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Notch signaling augments T cell responsiveness by enhancing CD25 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

The Notch regulator Numb links the Notch and TCR signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

MHC class II-specific T cells can develop in the CD8 lineage when CD4 is absent.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

The role of erk1 and erk2 in multiple stages of T cell development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

The nervous system and innate immunity: the neuropeptide connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Surface expression of Notch1 on thymocytes: correlation with the double-negative to double-positive transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Regulation of T lymphopoiesis by Notch1 and Lunatic fringe-mediated competition for intrathymic niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

The p300/CBP family: integrating signals with transcription factors and chromatin

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

XMam1, Xenopus Mastermind1, induces neural gene expression in a Notch-independent manner.

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

A role for CD5 in TCR-mediated signal transduction and thymocyte selection

21 January 2018

1 reference

https://api.crossref.org/works/10.1084%2FJEM.20070550

Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

Cytosolic interaction between deltex and Notch ankyrin repeats implicates deltex in the Notch signaling pathway.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2118698

A reassessment of the effect of activated Notch1 on CD4 and CD8 T cell development

27 November 2018

1 reference

12 December 2020

Gamma -secretase inhibitors repress thymocyte development

1 reference

12 December 2020

Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation

1 reference

12 December 2020

Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

1 reference

12 December 2020

Effects of a constitutively active form of calcineurin on T cell activation and thymic selection

1 reference

12 December 2020

CD53, a thymocyte selection marker whose induction requires a lower affinity TCR-MHC interaction than CD69, but is up-regulated with slower kinetics

1 reference

12 December 2020

Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice

1 reference

12 December 2020

Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

1 reference

12 December 2020

Degree of TCR internalization and Ca2+ flux correlates with thymocyte selection

1 reference

12 December 2020

1 reference

12 December 2020