Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation (Q28749176)

Expert Opinion on Drug Metabolism & Toxicology

Europe PubMed Central

title

Engineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediation (English)

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Santosh Kumar

1

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language of work or name

English

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publication date

February 2010

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published in

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volume

6

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issue

2

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page(s)

115-31

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cites work

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Biotechnological synthesis of the designer drug metabolite 4'-hydroxymethyl-alpha-pyrrolidinohexanophenone in fission yeast heterologously expressing human cytochrome P450 2D6--a versatile alternative to multistep chemical synthesis

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Identification of amino acid residues involved in 4-chloroindole 3-hydroxylation by cytochrome P450 2A6 using screening of random libraries

3 June 2018

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Directed enzyme evolution via small and effective neutral drift libraries

3 June 2018

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Transgenic rice plants expressing human p450 genes involved in xenobiotic metabolism for phytoremediation

3 June 2018

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Genotoxic potential of Polycyclic Aromatic Hydrocarbons-coated onto airborne Particulate Matter (PM 2.5) in human lung epithelial A549 cells.

3 June 2018

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Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.

3 June 2018

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Cytochrome P450 BM-3 evolved by random and saturation mutagenesis as an effective indole-hydroxylating catalyst

3 June 2018

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Advances in laboratory evolution of enzymes

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Heme-iron oxygenases: powerful industrial biocatalysts?

3 June 2018

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Quantitative whole-cell cytochrome P450 measurement suitable for high-throughput application

3 June 2018

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Engineering cytochrome p450 enzymes

3 June 2018

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Cytochrome P450s in the development of target-based anticancer drugs

3 June 2018

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Cytochrome p450 and chemical toxicology

3 June 2018

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3 June 2018

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Dissecting protein structure and function using directed evolution.

3 June 2018

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Robust quantitative modeling of peptide binding affinities for MHC molecules using physical-chemical descriptors

3 June 2018

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Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects

3 June 2018

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Collaboration between hepatic and intratumoral prodrug activation in a P450 prodrug-activation gene therapy model for cancer treatment

3 June 2018

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A shuffled CYP2C library with a high degree of structural integrity and functional versatility.

3 June 2018

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Enhancement of intratumoral cyclophosphamide pharmacokinetics and antitumor activity in a P450 2B11-based cancer gene therapy model

3 June 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Statistical analysis of physical-chemical properties and prediction of protein-protein interfaces

3 June 2018

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A shuffled CYP1A library shows both structural integrity and functional diversity.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Extending the capabilities of nature's most versatile catalysts: directed evolution of mammalian xenobiotic-metabolizing P450s.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Identification of a novel laser dye substrate of mammalian cytochromes P450: application in rapid kinetic analysis, inhibitor screening, and directed evolution

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Extending the diversity of cytochrome P450 enzymes by DNA family shuffling.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Re-engineering cytochrome P450 2B11dH for enhanced metabolism of several substrates including the anti-cancer prodrugs cyclophosphamide and ifosfamide

3 June 2018

1 reference

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Complex reactions catalyzed by cytochrome P450 enzymes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Herbicide resistance of transgenic rice plants expressing human CYP1A1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Novel enzymes through design and evolution.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Atypical cytochrome p450 kinetics: implications for drug discovery

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Investigation of the role of cytochrome P450 2B4 active site residues in substrate metabolism based on crystal structures of the ligand-bound enzyme

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochrome P450--redox partner fusion enzymes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Structure-function analysis of cytochromes P450 2B.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Preparation, characterization, and substrate metabolism of gold-immobilized cytochrome P450 2C9

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Enantioselective alpha-hydroxylation of 2-arylacetic acid derivatives and buspirone catalyzed by engineered cytochrome P450 BM-3.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Enhanced antitumor activity of P450 prodrug-based gene therapy using the low Km cyclophosphamide 4-hydroxylase P450 2B11.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochromes P450 as versatile biocatalysts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Biodegradation of dioxins by recombinant Escherichia coli expressing rat CYP1A1 or its mutant

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

11beta-Hydroxylation of Cortexolone (Reichstein Compound S) to Hydrocortisone by Curvularia lunata Entrapped in Photo-Cross-Linked Resin Gels

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Activation of oxazaphosphorines by cytochrome P450: application to gene-directed enzyme prodrug therapy for cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Expansion of substrate specificity of cytochrome P450 2A6 by random and site-directed mutagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Analysis of coumarin 7-hydroxylation activity of cytochrome P450 2A6 using random mutagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Structural diversity of human xenobiotic-metabolizing cytochrome P450 monooxygenases

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Use of directed evolution of mammalian cytochromes P450 for investigating the molecular basis of enzyme function and generating novel biocatalysts

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Enantioselective metabolism and cytotoxicity of R-ifosfamide and S-ifosfamide by tumor cell-expressed cytochromes P450.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochrome P450 biosensors-a review

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Electrochemical reduction of cytochrome P450 as an approach to the construction of biosensors and bioreactors

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochrome P450: nature's most versatile biological catalyst

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Biocatalytic production of perillyl alcohol from limonene by using a novel Mycobacterium sp. cytochrome P450 alkane hydroxylase expressed in Pseudomonas putida

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

From bench to bedside for gene-directed enzyme prodrug therapy of cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Exploring the potential of xenobiotic-metabolising enzymes as biocatalysts: evolving designer catalysts from polyfunctional cytochrome P450 enzymes.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Herbicide resistance in transgenic plants with mammalian P450 monooxygenase genes

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Structures of cytochrome P450 3A4.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Enhancement of 7-methoxyresorufin O-demethylation activity of human cytochrome P450 1A2 by molecular breeding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Using property based sequence motifs and 3D modeling to determine structure and functional regions of proteins.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Use of replication-conditional adenovirus as a helper system to enhance delivery of P450 prodrug-activation genes for cancer therapy

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Microbial P450 enzymes in biotechnology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

A self-sufficient peroxide-driven hydroxylation biocatalyst

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Plant cytochromes P450: tools for pharmacology, plant protection and phytoremediation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

PCBs, PCNs, PCDD/Fs, PAHs and Cl-PAHs in air and water particulate samples--patterns and variations

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochrome P450 enzymes in the generation of commercial products

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochrome P450 gene-directed enzyme prodrug therapy (GDEPT) for cancer

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Exploiting the versatility of human cytochrome P450 enzymes: the promise of blue roses from biotechnology

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Random mutagenesis of human cytochrome p450 2A6 and screening with indole oxidation products

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Analysis of mammalian cytochrome P450 structure and function by site-directed mutagenesis

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cytochromes P450 and metabolism of xenobiotics

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Oxidation of polychlorinated benzenes by genetically engineered CYP101 (cytochrome P450(cam)).

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Engineering of a functional human NADH-dependent cytochrome P450 system

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Rate-determining steps in phenacetin oxidations by human cytochrome P450 1A2 and selected mutants

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Engineering microsomal cytochrome P450 2C5 to be a soluble, monomeric enzyme. Mutations that alter aggregation, phospholipid dependence of catalysis, and membrane binding

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Laboratory evolution of peroxide-mediated cytochrome P450 hydroxylation

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Retroviral transfer of human cytochrome P450 genes for oxazaphosphorine-based cancer gene therapy.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Coupling of spin, substrate, and redox equilibriums in cytochrome P450

3 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes

3 June 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Preparative synthesis of drug metabolites using human cytochrome P450s 3A4, 2C9 and 1A2 with NADPH-P450 reductase expressed in Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Electrochemically driven drug metabolism by membranes containing human cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Stable long-term indigo production by overexpression of dioxygenase genes using a chromosomal integrated cascade expression circuit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Formation of indigo by recombinant mammalian cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Formation of the indigo precursor indican in genetically engineered tobacco plants and cell cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Impact of liver P450 reductase suppression on cyclophosphamide activation, pharmacokinetics and antitumoral activity in a cytochrome P450-based cancer gene therapy model

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Activation of the anticancer prodrugs cyclophosphamide and ifosfamide: identification of cytochrome P450 2B enzymes and site-specific mutants with improved enzyme kinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

CYP450 2B4 covalently attached to carbon and gold screen printed electrodes by diazonium salt and thiols monolayers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Novel therapeutic biosensor for indinavir-a protease inhibitor antiretroviral drug

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Protein and electrode engineering for the covalent immobilization of P450 BMP on gold.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Screen-printed electrodes based on carbon nanotubes and cytochrome P450scc for highly sensitive cholesterol biosensors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

CYP450 biosensors based on gold chips for antiepileptic drugs determination.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Electrochemistry of cytochrome P450 enzyme on nanoparticle-containing membrane-coated electrode and its applications for drug sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Amperometric responses of CYP2D6 drug metabolism nanobiosensor for sertraline: a selective serotonin reuptake inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Recombinant cytochrome p450 immobilization for biosensor applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Improving catalytic properties of P450 BM3 haem domain electrodes by molecular Lego.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

An explosive-degrading cytochrome P450 activity and its targeted application for the phytoremediation of RDX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Degradation of low molecular weight volatile organic compounds by plants genetically modified with mammalian cytochrome P450 2E1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Drug metabolism by Escherichia coli expressing human cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Thermostabilization of a cytochrome p450 peroxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Laboratory evolution of cytochrome p450 BM-3 monooxygenase for organic cosolvents

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Engineering mammalian cytochrome P450 2B1 by directed evolution for enhanced catalytic tolerance to temperature and dimethyl sulfoxide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

High-throughput measurement of protein stability in microtiter plates

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Laboratory evolution of a soluble, self-sufficient, highly active alkane hydroxylase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Regio- and enantioselective alkane hydroxylation with engineered cytochromes P450 BM-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Direct conversion of ethane to ethanol by engineered cytochrome P450 BM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Preparation of human metabolites of propranolol using laboratory-evolved bacterial cytochromes P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Engineered alkane-hydroxylating cytochrome P450(BM3) exhibiting nativelike catalytic properties

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Evolved CYP102A1 (P450BM3) variants oxidise a range of non-natural substrates and offer new selectivity options

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Butane and propane oxidation by engineered cytochrome P450cam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Engineering the CYP101 system for in vivo oxidation of unnatural substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

The heme monooxygenase cytochrome P450cam can be engineered to oxidize ethane to ethanol

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

A truncation of 2B subfamily cytochromes P450 yields increased expression levels, increased solubility, and decreased aggregation while retaining function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Rational engineering of human cytochrome P450 2B6 for enhanced expression and stability: importance of a Leu264->Phe substitution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Role of cytochrome B5 in modulating peroxide-supported cyp3a4 activity: evidence for a conformational transition and cytochrome P450 heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Phytoremediation of the herbicides atrazine and metolachlor by transgenic rice plants expressing human CYP1A1, CYP2B6, and CYP2C19

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Selection of human cytochrome P450 1A2 mutants with enhanced catalytic activity for heterocyclic amine N-hydroxylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17425250903431040

Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Technology evaluation: MetXia-P450, Oxford Biomedica.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Cost-effective whole-cell assay for laboratory evolution of hydroxylases in Escherichia coli

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

Frequent, moderate-dose cyclophosphamide administration improves the efficacy of cytochrome P-450/cytochrome P-450 reductase-based cancer gene therapy

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2811222

2,2',5,5'-Tetrachlorobiphenyl: isolation and identification of metabolites generated by rat liver microsomes

27 November 2018

1 reference

12 December 2020

1 reference

12 December 2020

2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11

1 reference

12 December 2020

Catalytic reductive dehalogenation of hexachloroethane by molecular variants of cytochrome P450cam (CYP101)

1 reference

12 December 2020

Immobilization and activity assay of cytochrome P450 on patterned lipid membranes

1 reference

12 December 2020

Immobilization of P450 monooxygenase and chloroplast for use in light-driven bioreactors

1 reference

12 December 2020

Macrolide antibiotic biosynthesis: isolation and properties of two forms of 6-deoxyerythronolide B hydroxylase from Saccharopolyspora erythraea (Streptomyces erythreus)

1 reference

12 December 2020

Allosteric P450 mechanisms: multiple binding sites, multiple conformers or both?

1 reference

12 December 2020

Cytochrome P450 immobilisation as a route to bioremediation/biocatalysis

1 reference

12 December 2020

Functional Interactions in Cytochrome P450BM3: Flavin Semiquinone Intermediates, Role of NADP(H), and Mechanism of Electron Transfer by the Flavoprotein Domain†

1 reference

12 December 2020

10.1517/17425250903431040

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

55495

OpenCitations bibliographic resource ID

55495

1 reference