Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton (Q30167854)

9 June 2017

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title

Nck/Dock: an adapter between cell surface receptors and the actin cytoskeleton (English)

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9 June 2017

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Li W

1

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9 June 2017

Fan J

series ordinal

2

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9 June 2017

Woodley DT

series ordinal

3

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9 June 2017

language of work or name

English

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publication date

1 October 2001

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9 June 2017

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9 June 2017

20

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9 June 2017

44

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9 June 2017

6403-6417

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Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development

9 June 2017

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Platelet-derived growth factor and fibronectin-stimulated migration are differentially regulated by the Rac and extracellular signal-regulated kinase pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The Wiskott-Aldrich syndrome protein-interacting protein (WIP) binds to the adaptor protein Nck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A novel regulator of p21-activated kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

SH2 and SH3-containing adaptor proteins: redundant or independent mediators of intracellular signal transduction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Insulin-like growth factor-I and platelet-derived growth factor-BB induce directed migration of human arterial smooth muscle cells via signaling pathways that are distinct from those of proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Sphingosine-1-phosphate inhibits PDGF-induced chemotaxis of human arterial smooth muscle cells: spatial and temporal modulation of PDGF chemotactic signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Translocation of the Rac1 guanine nucleotide exchange factor Tiam1 induced by platelet-derived growth factor and lysophosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Regulation of PAK activation and the T cell cytoskeleton by the linker protein SLP-76

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Identification of Nck family genes, chromosomal localization, expression, and signaling specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Nckbeta adapter regulates actin polymerization in NIH 3T3 fibroblasts in response to platelet-derived growth factor bb

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Regulation of cell contraction and membrane ruffling by distinct signals in migratory cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A Drosophila protein-tyrosine phosphatase associates with an adapter protein required for axonal guidance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Membrane targeting of p21-activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Regulation of macropinocytosis by p21-activated kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The Eph family in the patterning of neural development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Growth factors and wound healing: platelet-derived growth factor as a model cytokine

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The ephrins and Eph receptors in neural development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Actin-based motility of vaccinia virus mimics receptor tyrosine kinase signalling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Retinal axon target selection in Drosophila is regulated by a receptor protein tyrosine phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Drosophila photoreceptor axon guidance and targeting requires the dreadlocks SH2/SH3 adapter protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Regulation of actin polymerization by Arp2/3 complex and WASp/Scar proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Tyrosine-614, the major autophosphorylation site of the receptor tyrosine kinase HEK2, functions as multi-docking site for SH2-domain mediated interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Juxtamembrane tyrosine residues couple the Eph family receptor EphB2/Nuk to specific SH2 domain proteins in neuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Tyrosine 1213 of Flt-1 is a major binding site of Nck and SHP-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Connecting signaling and cell cycle progression in growth factor-stimulated cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

RAC regulation of actin polymerization and proliferation by a pathway distinct from Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A role for p21-activated kinase in endothelial cell migration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Activation of Rac1 by a Crk SH3-binding protein, DOCK180

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Evidence that DOCK180 up-regulates signals from the CrkII-p130(Cas) complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Molecular cloning of p125Nap1, a protein that associates with an SH3 domain of Nck

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The p21Rac/Cdc42-activated kinases (PAKs).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Regulation of chemotaxis by the platelet-derived growth factor receptor-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Signaling by the germinal center kinase family of protein kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Nck, a melanoma cDNA encoding a cytoplasmic protein consisting of the src homology units SH2 and SH3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Structural determinants of peptide-binding orientation and of sequence specificity in SH3 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Localization of LAT in glycolipid-enriched microdomains is required for T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Mechanism of activation of Pak1 kinase by membrane localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The GRB family of SH2 domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Protein-protein interactions in signaling cascades

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The SH2/SH3 domain-containing protein Nck is recognized by certain anti-phospholipase C-gamma 1 monoclonal antibodies, and its phosphorylation on tyrosine is stimulated by platelet-derived growth factor and epidermal growth factor treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A complex of N-WASP and WIP integrates signalling cascades that lead to actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Trio combines with dock to regulate Pak activity during photoreceptor axon pathfinding in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

PAK promotes morphological changes by acting upstream of Rac.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Eph receptors and ephrins in neural development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Characterization of a novel Src-like adapter protein that associates with the Eck receptor tyrosine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Phosphorylation of Nck in response to a variety of receptors, phorbol myristate acetate, and cyclic AMP

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Protein modules and signalling networks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Pharmacologic enhancement of wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Isolation of a NCK-associated kinase, PRK2, an SH3-binding protein and potential effector of Rho protein signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Domain requirements for the Dock adapter protein in growth- cone signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Identification of the receptor-associated signaling enzymes that are required for platelet-derived growth factor-AA-dependent chemotaxis and DNA synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The pathogenesis of atherosclerosis: a perspective for the 1990s

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The SH2/SH3 adaptor protein dock interacts with the Ste20-like kinase misshapen in controlling growth cone motility

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

SH2/SH3 signaling proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Drosophila Dscam is an axon guidance receptor exhibiting extraordinary molecular diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Emerging from the Pak: the p21-activated protein kinase family.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Temporal and spatial distribution of activated Pak1 in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Activation of the Abl tyrosine kinase in vivo by Src homology 3 domains from the Src homology 2/Src homology 3 adaptor Nck.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Signal transduction underlying growth cone guidance by diffusible factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Nck recruitment to Eph receptor, EphB1/ELK, couples ligand activation to c-Jun kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

UNC-73 activates the Rac GTPase and is required for cell and growth cone migrations in C. elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

NCK and PAK participate in the signaling pathway by which vascular endothelial growth factor stimulates the assembly of focal adhesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The Ste20 kinase misshapen regulates both photoreceptor axon targeting and dorsal closure, acting downstream of distinct signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

misshapen encodes a protein kinase involved in cell shape control in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Identification and kinetic analysis of the interaction between Nck-2 and DOCK180

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Ephrin-A5 induces collapse of growth cones by activating Rho and Rho kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

DSCAM: a novel member of the immunoglobulin superfamily maps in a Down syndrome region and is involved in the development of the nervous system

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

alphaPIX nucleotide exchange factor is activated by interaction with phosphatidylinositol 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Interaction between PAK and nck: a template for Nck targets and role of PAK autophosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Coupling of PAK-interacting exchange factor PIX to GIT1 promotes focal complex disassembly

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

How WASP regulates actin polymerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1204782

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Identifiers

DOI

10.1038/SJ.ONC.1204782

1 reference

Dimensions Publication ID

9 June 2017

0 references

1 reference