Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens (Q30318077)

17 June 2017

Fungal cytochrome P450 sterol 14α-demethylase (CYP51) and azole resistance in plant and human pathogens (English)

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17 June 2017

Rayko Becher

1

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17 June 2017

Stefan G R Wirsel

series ordinal

2

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17 June 2017

language of work or name

English

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publication date

12 June 2012

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Applied Microbiology and Biotechnology

17 June 2017

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17 June 2017

95

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17 June 2017

4

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17 June 2017

825-840

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https://scigraph.springernature.com/pub.10.1007/s00253-012-4195-9

17 June 2017

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21 January 2018

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Development of a novel multiplex DNA microarray for Fusarium graminearum and analysis of azole fungicide responses

21 January 2018

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Characterization and catalytic properties of the sterol 14alpha-demethylase from Mycobacterium tuberculosis

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Fluconazole binding and sterol demethylation in three CYP51 isoforms indicate differences in active site topology

21 January 2018

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Modeling cytochrome P450 14 alpha demethylase (Candida albicans) from P450cam.

21 January 2018

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Evolution of the CYP51 gene in Mycosphaerella graminicola: evidence for intragenic recombination and selective replacement.

21 January 2018

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Analysis of the CYP51 gene and encoded protein in propiconazole-resistant isolates of Mycosphaerella fijiensis

21 January 2018

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Efflux-mediated antifungal drug resistance.

21 January 2018

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Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibility to azoles

21 January 2018

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Structural Characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei Bound to the Antifungal Drugs Posaconazole and Fluconazole

21 January 2018

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Recent trends in the epidemiology of invasive mycoses

21 January 2018

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Heterologous expression of mutated eburicol 14alpha-demethylase (CYP51) proteins of Mycosphaerella graminicola to assess effects on azole fungicide sensitivity and intrinsic protein function

21 January 2018

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Impact of recently emerged sterol 14{alpha}-demethylase (CYP51) variants of Mycosphaerella graminicola on azole fungicide sensitivity

21 January 2018

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Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

21 January 2018

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Cytochemical and Biochemical Studies of Yeasts After In Vitro Exposure to Miconazole

21 January 2018

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Impact of fungal drug transporters on fungicide sensitivity, multidrug resistance and virulence

21 January 2018

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PCR cloning and detection of point mutations in the eburicol 14alpha-demethylase (CYP51) gene from Erysiphe graminis f. sp. hordei, a "recalcitrant" fungus.

21 January 2018

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Assessment of fungicide resistance and pathogen diversity in Erysiphe necator using quantitative real-time PCR assays.

21 January 2018

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A gain-of-function mutation in the transcription factor Upc2p causes upregulation of ergosterol biosynthesis genes and increased fluconazole resistance in a clinical Candida albicans isolate.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

An improved model of the Aspergillus fumigatus CYP51A protein

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Development of azole resistance during fluconazole maintenance therapy for AIDS-associated cryptococcal disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Genetic basis for differential activities of fluconazole and voriconazole against Candida krusei

21 January 2018

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Differences in interactions between azole drugs related to modifications in the 14-alpha sterol demethylase gene (cyp51A) of Aspergillus fumigatus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Modeling and interactions of Aspergillus fumigatus lanosterol 14-alpha demethylase 'A' with azole antifungals.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Multidrug resistance in fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Tandem repeat of a transcriptional enhancer upstream of the sterol 14alpha-demethylase gene (CYP51) in Penicillium digitatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Homology modeling and screening of new 14α-demethylase inhibitor (DMI) fungicides based on optimized expression of CYP51 from Ustilago maydis in Escherichia coli

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Cytochrome P450 systems--biological variations of electron transport chains.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Essential gene identification and drug target prioritization in Aspergillus fumigatus

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Genetic analysis of azole resistance in the Darlington strain of Candida albicans

21 January 2018

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Mode of action and resistance to azole antifungals associated with the formation of 14 alpha-methylergosta-8,24(28)-dien-3 beta,6 alpha-diol.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Stem rust of wheat 3300 years old found in Israel.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Fluconazole and voriconazole multidisk testing of Candida species for disk test calibration and MIC estimation

21 January 2018

1 reference

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Effects of Y132H and F145L substitutions on the activity, azole resistance and spectral properties of Candida albicans sterol 14-demethylase P450 (CYP51): a live example showing the selection of altered P450 through interaction with environmental co

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Cytochromes P450 and drug discovery

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

CYP51--the omnipotent P450.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Sterol 14alpha-demethylase cytochrome P450 (CYP51), a P450 in all biological kingdoms

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Structural basis for conservation in the CYP51 family

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Multiple mechanisms account for resistance to sterol 14α-demethylation inhibitors in field isolates of Mycosphaerella graminicola

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Changes in susceptibility to posaconazole in clinical isolates of Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Gene transcription profiling of Fusarium graminearum treated with an azole fungicide tebuconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Paralogous cyp51 genes in Fusarium graminearum mediate differential sensitivity to sterol demethylation inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Azole resistance in Aspergillus fumigatus isolates from the ARTEMIS global surveillance study is primarily due to the TR/L98H mutation in the cyp51A gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Adaptation to fungicides in Monilinia fructicola isolates with different fungicide resistance phenotypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

The cytochrome P450 lanosterol 14alpha-demethylase gene is a demethylation inhibitor fungicide resistance determinant in Monilinia fructicola field isolates from Georgia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Overexpression of the 14alpha-demethylase target gene (CYP51) mediates fungicide resistance in Blumeriella jaapii

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Changing epidemiology of rare mould infections: implications for therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Complementation of a Saccharomyces cerevisiae ERG11/CYP51 (sterol 14α-demethylase) doxycycline-regulated mutant and screening of the azole sensitivity of Aspergillus fumigatus isoenzymes CYP51A and CYP51B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Identification of two different 14-alpha sterol demethylase-related genes (cyp51A and cyp51B) in Aspergillus fumigatus and other Aspergillus species

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Screening for amino acid substitutions in the Candida albicans Erg11 protein of azole-susceptible and azole-resistant clinical isolates: new substitutions and a review of the literature.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Regulation of multidrug resistance in pathogenic fungi

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Aspergillus species and other molds in respiratory samples from patients with cystic fibrosis: a laboratory-based study with focus on Aspergillus fumigatus azole resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Molecular modelling of the emergence of azole resistance in Mycosphaerella graminicola

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Molecular characterization and detection of overexpressed C-14 alpha-demethylase-based DMI resistance in Cercospora beticola field isolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Epidemiology of opportunistic fungal infections in Latin America.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Heterologous expression and characterization of the sterol 14α-demethylase CYP51F1 from Candida albicans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Epidemiology of invasive mycoses in North America

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Wild-type MIC distributions and epidemiological cutoff values for posaconazole and voriconazole and Candida spp. as determined by 24-hour CLSI broth microdilution

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Crystal structure of cytochrome P450 14 -sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with azole inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Substrate recognition sites in 14alpha-sterol demethylase from comparative analysis of amino acid sequences and X-ray structure of Mycobacterium tuberculosis CYP51.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Occurrence, Distribution, and Polymerase Chain Reaction-Based Detection of Resistance to Sterol Demethylation Inhibitor Fungicides in Populations of Blumeriella jaapii in Michigan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Changing patterns and trends in systemic fungal infections

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Epidemiological cutoffs and cross-resistance to azole drugs in Aspergillus fumigatus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Molecular design of two sterol 14alpha-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Amino acid substitutions in the cytochrome P-450 lanosterol 14alpha-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

The 14alpha-Demethylasse(CYP51A1) Gene is Overexpressed in Venturia inaequalis Strains Resistant to Myclobutanil

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Three-dimensional model of lanosterol 14 alpha-demethylase from Cryptococcus neoformans: active-site characterization and insights into azole binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Increased sensitivity of Candida albicans cells accumulating 14 alpha-methylated sterols to active oxygen: possible relevance to in vivo efficacies of azole antifungal agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Heteroresistance to fluconazole in Cryptococcus neoformans is intrinsic and associated with virulence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Possible environmental origin of resistance of Aspergillus fumigatus to medical triazoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Azole resistance profile of amino acid changes in Aspergillus fumigatus CYP51A based on protein homology modeling.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Structural basis of human CYP51 inhibition by antifungal azoles

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

PdCYP51B, a new putative sterol 14α-demethylase gene of Penicillium digitatum involved in resistance to imazalil and other fungicides inhibiting ergosterol synthesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Azole binding properties of Candida albicans sterol 14-alpha demethylase (CaCYP51).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Emergence of resistance to fluconazole as a cause of failure during treatment of histoplasmosis in patients with acquired immunodeficiency disease syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Sequence variation in the CYP51 gene of Blumeria graminis associated with resistance to sterol demethylase inhibiting fungicides

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

A sterol 14α-demethylase is required for conidiation, virulence and for mediating sensitivity to sterol demethylation inhibitors by the rice blast fungus Magnaporthe oryzae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Expression and homology modelling of sterol 14alpha-demethylase of Magnaporthe grisea and its interaction with azoles.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

Expression and homology modeling of sterol 14alpha-demethylase from Penicillium digitatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

New resistance mechanisms to azole drugs inAspergillus fumigatusand emergence of antifungal drugs-resistantA. fumigatusatypical strains

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00253-012-4195-9

10.1007/S00253-012-4195-9

21 January 2018

Identifiers

DOI

1 reference

Dimensions Publication ID

17 June 2017

0 references

1 reference