Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway (Q30464719)

12 August 2017

Regulation of c-Myc Protein Abundance by a Protein Phosphatase 2A-Glycogen Synthase Kinase 3β-Negative Feedback Pathway (English)

1 reference

12 August 2017

Lingfeng Liu

1

1 reference

PMCID

3415666

12 August 2017

Robert N Eisenman

series ordinal

2

1 reference

12 August 2017

1 January 2012

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12 August 2017

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12 August 2017

3

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12 August 2017

1

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12 August 2017

23-36

1 reference

PMCID

3415666

describes a project that uses

12 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3415666/fullTextXML

inferred from PubMed Central ID database lookup

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From promiscuity to precision: protein phosphatases get a makeover

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20 June 2018

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GSK-3beta acts downstream of PP2A and the PI 3-kinase-Akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis

20 June 2018

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CIP2A inhibits PP2A in human malignancies

20 June 2018

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Non-transcriptional control of DNA replication by c-Myc

20 June 2018

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Gene splicing and mutagenesis by PCR-driven overlap extension

20 June 2018

1 reference

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Structure of the protein phosphatase 2A holoenzyme

20 June 2018

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The Myc oncoprotein as a therapeutic target for human cancer

20 June 2018

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Aberrant stabilization of c-Myc protein in some lymphoblastic leukemias.

20 June 2018

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20 June 2018

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Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

20 June 2018

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The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.

20 June 2018

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Membrane depolarization induces the undulating phosphorylation/dephosphorylation of glycogen synthase kinase 3beta, and this dephosphorylation involves protein phosphatases 2A and 2B in SH-SY5Y human neuroblastoma cells

20 June 2018

1 reference

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Myc degradation: dancing with ubiquitin ligases.

20 June 2018

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The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

20 June 2018

1 reference

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Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

20 June 2018

1 reference

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A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells

20 June 2018

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GSK-3-selective inhibitors derived from Tyrian purple indirubins

20 June 2018

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Phosphorylation by Glycogen Synthase Kinase-3 Controls c-Myc Proteolysis and Subnuclear Localization

20 June 2018

1 reference

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Skp2 regulates Myc protein stability and activity

20 June 2018

1 reference

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GSK-3: tricks of the trade for a multi-tasking kinase

20 June 2018

1 reference

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Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

20 June 2018

1 reference

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GSK3 takes centre stage more than 20 years after its discovery

20 June 2018

1 reference

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Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus

20 June 2018

1 reference

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A common phosphate binding site explains the unique substrate specificity of GSK3 and its inactivation by phosphorylation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Protein phosphatase 2A: the Trojan Horse of cellular signaling

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

The transcriptional program of a human B cell line in response to Myc

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

c-Myc proteolysis by the ubiquitin-proteasome pathway: stabilization of c-Myc in Burkitt's lymphoma cells

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Protein phosphatase 2A: a panoply of enzymes.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Functional overlap of sequences that activate transcription and signal ubiquitin-mediated proteolysis

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Control of cell growth by c-Myc in the absence of cell division

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Ras enhances Myc protein stability.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Universal and rapid salt-extraction of high quality genomic DNA for PCR-based techniques

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Protein kinase FA/glycogen synthase kinase-3 predominantly phosphorylates the in vivo site Thr97-Pro in brain myelin basic protein: evidence for Thr-Pro and Ser-Arg-X-X-Ser as consensus sequence motifs.

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Prolonged N-myc protein half-life in a neuroblastoma cell line lacking N-myc amplification

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Okadaic acid: a new probe for the study of cellular regulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation

20 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism.

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

The Drosophila F box protein archipelago regulates dMyc protein levels in vivo

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

26 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3415666

Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells

26 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22893788

12 December 2020

inferred from PubMed ID database lookup

Protein phosphatase 2A is the major enzyme in brain that dephosphorylates tau protein phosphorylated by proline-directed protein kinases or cyclic AMP-dependent protein kinase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22893788

12 December 2020

inferred from PubMed ID database lookup

A p53-dependent mouse spindle checkpoint

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22893788

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1177/1947601912448067

1 reference

12 August 2017

1 reference

12 August 2017

1 reference

PMCID

3415666