Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1. (Q30687417)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

title

Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

0 references

0 references

1 reference

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Teppei Shimamura

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

11

Satoru Miyano

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

10

Seiya Imoto

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

author name string

Sam S Barclay

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Takuya Tamura

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Kyota Fujita

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Kazuhiko Tagawa

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Asuka Katsuta

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Hiroki Shiwaku

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Masaki Sone

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

Hitoshi Okazawa

12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

publication date

31 October 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

published in

Human Molecular Genetics

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

volume

23

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

issue

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

29 February 2020

page(s)

1345-1364

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24179173%20AND%20SRC:MED&resulttype=core&format=json

Autophagy and polyglutamine diseases

29 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Genetic modulation of polyglutamine toxicity by protein conjugation pathways in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Molecular chaperones enhance the degradation of expanded polyglutamine repeat androgen receptor in a cellular model of spinal and bulbar muscular atrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Expression of expanded repeat androgen receptor produces neurologic disease in transgenic mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Polyglutamine-expanded androgen receptors form aggregates that sequester heat shock proteins, proteasome components and SRC-1, and are suppressed by the HDJ-2 chaperone

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Evidence for proteasome involvement in polyglutamine disease: localization to nuclear inclusions in SCA3/MJD and suppression of polyglutamine aggregation in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Eukaryotic proteasomes cannot digest polyglutamine sequences and release them during degradation of polyglutamine-containing proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Inefficient degradation of truncated polyglutamine proteins by the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-1alpha in Huntington's disease neurodegeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Expanded polyglutamine stretches interact with TAFII130, interfering with CREB-dependent transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Altered transcription in yeast expressing expanded polyglutamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A novel protein with RNA-binding motifs interacts with ataxin-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

PQBP-1/Npw38, a nuclear protein binding to the polyglutamine tract, interacts with U5-15kD/dim1p via the carboxyl-terminal domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

OGG1 initiates age-dependent CAG trinucleotide expansion in somatic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Proteome analysis of soluble nuclear proteins reveals that HMGB1/2 suppress genotoxic stress in polyglutamine diseases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Mutant huntingtin impairs Ku70-mediated DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

An untranslated CTG expansion causes a novel form of spinocerebellar ataxia (SCA8)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

RNA toxicity is a component of ataxin-3 degeneration in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Spinocerebellar ataxia type 31 is associated with "inserted" penta-nucleotide repeats containing (TGGAA)n

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

CAG expansion induces nucleolar stress in polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Effects of overexpression of huntingtin proteins on mitochondrial integrity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Identification and characterization of the gene causing type 1 spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

14-3-3 Binding to ataxin-1(ATXN1) regulates its dephosphorylation at Ser-776 and transport to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

ATAXIN-1 interacts with the repressor Capicua in its native complex to cause SCA1 neuropathology

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

RORalpha-mediated Purkinje cell development determines disease severity in adult SCA1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Small nuclear ribonucleoprotein remodeling during catalytic activation of the spliceosome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A subset of human 35S U5 proteins, including Prp19, function prior to catalytic step 1 of splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Cell biology of spinocerebellar ataxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Transcription-coupled DNA repair: two decades of progress and surprises

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Determinants and dynamics of genome accessibility

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Neighborly DISCourse: DNA double strand breaks silence transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

DNA damage regulates alternative splicing through inhibition of RNA polymerase II elongation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Drosophila SPF45: a bifunctional protein with roles in both splicing and DNA repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Ku70 alleviates neurodegeneration in Drosophila models of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

DNA double-strand break signaling and human disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

DNA mismatch repair-induced double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Megabase chromatin domains involved in DNA double-strand breaks in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Identification of genes that modify ataxin-1-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Multiple-pathway analysis of double-strand break repair mutations in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A long CAG repeat in the mouse Sca1 locus replicates SCA1 features and reveals the impact of protein solubility on selective neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Mutant SOD1 in cell types other than motor neurons and oligodendrocytes accelerates onset of disease in ALS mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Cerebellum- and forebrain-derived stem cells possess intrinsic regional character

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

RECQL5 helicase: connections to DNA recombination and RNA polymerase II transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

XRCC1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The involvement of DNA-damage and -repair defects in neurological dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Disorders of nucleotide excision repair: the genetic and molecular basis of heterogeneity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

DNA polymerase gamma, the mitochondrial replicase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Human premature aging, DNA repair and RecQ helicases

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The DNA Damage Response: Making It Safe to Play with Knives

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Chk1 in the DNA damage response: conserved roles from yeasts to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Defective DNA repair and neurodegenerative disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

A subgroup of spinocerebellar ataxias defective in DNA damage responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The FHA domain of aprataxin interacts with the C-terminal region of XRCC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia-ocular apraxia 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Human senataxin resolves RNA/DNA hybrids formed at transcriptional pause sites to promote Xrn2-dependent termination

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

Functional role for senataxin, defective in ataxia oculomotor apraxia type 2, in transcriptional regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524

The AXH module: an independently folded domain common to ataxin-1 and HBP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FHMG%2FDDT524