Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability (Q31044030)

28 June 2017

Prediction of in vivo drug clearance from in vitro data. I: impact of inter-individual variability (English)

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28 June 2017

Howgate EM

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28 June 2017

Rowland Yeo K

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28 June 2017

Proctor NJ

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28 June 2017

Tucker GT

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28 June 2017

Rostami-Hodjegan A

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28 June 2017

language of work or name

English

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publication date

1 June 2006

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28 June 2017

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28 June 2017

36

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28 June 2017

6

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28 June 2017

473-497

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https://api.crossref.org/works/10.1080%2F00498250600683197

28 June 2017

1 reference

Pharmacokinetics and bioavailability of omeprazole after single and repeated oral administration in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The influence of nonspecific microsomal binding on apparent intrinsic clearance, and its prediction from physicochemical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Coadministration of nefazodone and benzodiazepines: II. A pharmacokinetic interaction study with triazolam

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Caffeine renal clearance and urine caffeine concentrations during steady state dosing. Implications for monitoring caffeine intake during sports events

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Prediction of in vivo drug-drug interactions from in vitro data: impact of incorporating parallel pathways of drug elimination and inhibitor absorption rate constant

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Influence of CYP2D6 polymorphism on the pharmacokinetics and pharmacodynamic of tolterodine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Fluoxetine inhibits the metabolism of tolterodine-pharmacokinetic implications and proposed clinical relevance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The influence of CYP2D6 polymorphism and quinidine on the disposition and antitussive effect of dextromethorphan in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Microsomal prediction of in vivo clearance of CYP2C9 substrates in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Stereochemical aspects of warfarin drug interactions: use of a combined pharmacokinetic-pharmacodynamic model.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Prediction of creatinine clearance from serum creatinine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparison of (S)-mephenytoin and proguanil oxidation in vitro: contribution of several CYP isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

In vitro metabolism of cyclosporine A by human kidney CYP3A5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The potential for CYP2D6 inhibition screening using a novel scintillation proximity assay-based approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetics and pharmacodynamics of triazolam after two intermittent doses in obese and normal-weight men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Inhibition of CYP2E1 by chlormethiazole as measured by chlorzoxazone pharmacokinetics in patients with alcoholism and in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

21 January 2018

Triazolam disposition

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The involvement of CYP1A2 and CYP3A4 in the metabolism of clozapine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

CYP2E1 activity before and after weight loss in morbidly obese subjects with nonalcoholic fatty liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Population study of triazolam pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Utility of recombinant enzyme kinetics in prediction of human clearance: impact of variability, CYP3A5, and CYP2C19 on CYP3A4 probe substrates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Reduced clearance of triazolam in old age: relation to antipyrine oxidizing capacity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative kinetics and dynamics of zaleplon, zolpidem, and placebo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Differential impairment of triazolam and zolpidem clearance by ritonavir

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetics of oral cyclosporin A (Sandimmun) in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Biotransformation of caffeine by cDNA-expressed human cytochromes P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Effect of caffeine on clozapine pharmacokinetics in healthy volunteers

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Standard liver volume in the Caucasian population.

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetics and bioavailability of midazolam in man

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Prediction of hepatic clearance from microsomes, hepatocytes, and liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Identification of the cytochrome P450 enzymes involved in the N-demethylation of sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Prediction of in vivo drug disposition from in vitro data based on physiological pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Modelling approaches to dose estimation in children

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Influence of menstrual cycle and gender on alprazolam pharmacokinetics

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Physiologic and temporal variation in hepatic elimination of midazolam.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Evaluation of cytochrome P4502C9 metabolic activity with tolbutamide in CYP2C91 heterozygotes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative pharmacokinetics of caffeine and its primary demethylated metabolites paraxanthine, theobromine and theophylline in man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Structural characteristics of human P450s involved in drug metabolism: QSARs and lipophilicity profiles

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Fluvoxamine inhibits the CYP2C9 catalyzed biotransformation of tolbutamide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Characterization of transgenic mouse strains using six human hepatic cytochrome P450 probe substrates

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolam

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Nonspecific binding of drugs to human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Gender-dependent racial difference in disposition of cyclosporine among healthy African American and white volunteers

21 January 2018

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https://api.crossref.org/works/10.1080%2F00498250600683197

Failure of ‘therapeutic’ doses of beta-adrenoceptor antagonists to alter the disposition of tolbutamide and lignocaine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Physiologically based modelling of inhibition of metabolism and assessment of the relative potency of drug and metabolite: dextromethorphan vs. dextrorphan using quinidine inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative human pharmacokinetics and metabolism of single-dose oral and intravenous sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The effects of age and renal and hepatic impairment on the pharmacokinetics of sildenafil

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Incorporating measures of variability and uncertainty into the prediction of in vivo hepatic clearance from in vitro data

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Effect of fasting and obesity in humans on the 6-hydroxylation of chlorzoxazone: a putative probe of CYP2E1 activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Fentanyl inhibits metabolism of midazolam: competitive inhibition of CYP3A4 in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetic properties of zolpidem in elderly and young adults: possible modulation by testosterone in men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

EEG profile of intravenous zolpidem in healthy volunteers.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Prediction of pharmacokinetics prior to in vivo studies. 1. Mechanism-based prediction of volume of distribution.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Investigation of multiple dose citalopram on the pharmacokinetics and pharmacodynamics of racemic warfarin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Predicting drug clearance from recombinantly expressed CYPs: intersystem extrapolation factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Effect of modafinil at steady state on the single-dose pharmacokinetic profile of warfarin in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Clinical pharmacokinetics and pharmacodynamics of zolpidem. Therapeutic implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetics of clozapine and its metabolites in psychiatric patients: plasma protein binding and renal clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Pharmacokinetics of dextromethorphan and metabolites in humans: influence of the CYP2D6 phenotype and quinidine inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Cyclosporine pharmacokinetics and pharmacodynamics in African American and white subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Co-administration of ciprofloxacin and cyclosporin: lack of evidence for a pharmacokinetic interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

A novel model for prediction of human drug clearance by allometric scaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Accuracy of allometrically predicted pharmacokinetic parameters in humans: role of species selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Utility of recombinant cytochrome p450 enzymes: a drug metabolism perspective.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

CYP3A activity in African American and European American men: population differences and functional effect of the CYP3A4*1B5'-promoter region polymorphism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Diabetes mellitus increases the in vivo activity of cytochrome P450 2E1 in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Commentary: a physiological approach to hepatic drug clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Tenidap sodium does not alter the clearance or plasma protein binding of tolbutamide in healthy male volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Comparative studies on the catalytic roles of cytochrome P450 2C9 and its Cys- and Leu-variants in the oxidation of warfarin, flurbiprofen, and diclofenac by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Assessment of CYP2D6 and CYP2C19 activity in vivo in humans: A cocktail study with dextromethorphan and chloroguanide alone and in combination

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

Triazolam pharmacokinetics and pharmacodynamics in Caucasians and Southern Asians: ethnicity and CYP3A activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F00498250600683197

10.1080/00498250600683197

21 January 2018

Identifiers

DOI

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28 June 2017

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