How protein stability and new functions trade off (Q33332450)

25 July 2017

How protein stability and new functions trade off (English)

1 reference

25 July 2017

Nobuhiko Tokuriki

1

1 reference

25 July 2017

Francois Stricher

series ordinal

2

1 reference

25 July 2017

Luis Serrano

series ordinal

3

1 reference

25 July 2017

Dan S Tawfik

series ordinal

4

1 reference

25 July 2017

29 February 2008

1 reference

PLOS Computational Biology

25 July 2017

1 reference

25 July 2017

4

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25 July 2017

e1000002

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25 July 2017

2

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Creative Commons Attribution 4.0 International

25 July 2017

start time

29 February 2008

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Genetic constraints on protein evolution

1 reference

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The selection of acceptable protein mutations

14 July 2018

1 reference

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Stability for function trade-offs in the enolase superfamily "catalytic module"

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

The stability effects of protein mutations appear to be universally distributed

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Highly tolerated amino acid substitutions increase the fidelity of Escherichia coli DNA polymerase I.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Empirical fitness landscapes reveal accessible evolutionary paths

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Robustness-epistasis link shapes the fitness landscape of a randomly drifting protein.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Thermodynamics of neutral protein evolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Relative tolerance of mesostable and thermostable protein homologs to extensive mutation

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Computer-based design of novel protein structures

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

An integrated view of protein evolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Protein stability promotes evolvability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

A statistical analysis of random mutagenesis methods used for directed protein evolution.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Mimicking natural evolution in metallo-beta-lactamases through second-shell ligand mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Missense meanderings in sequence space: a biophysical view of protein evolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Evolving strategies for enzyme engineering

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

The FoldX web server: an online force field

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Improving enzyme properties: when are closer mutations better?

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Structure, function, and inhibition along the reaction coordinate of CTX-M beta-lactamases

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Thermodynamic prediction of protein neutrality

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

The 'evolvability' of promiscuous protein functions

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Protein tolerance to random amino acid change

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

The relationship between conservation, thermodynamic stability, and function in the SH3 domain hydrophobic core

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Selection of mutations for increased protein stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Structural bases of stability-function tradeoffs in enzymes

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Predicting changes in the stability of proteins and protein complexes: a study of more than 1000 mutations

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

De novo design of biocatalysts

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Engineering proteins for thermostability: the use of sequence alignments versus rational design and directed evolution

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Emerging principles of de novo catalyst design.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Divergent evolution of enzymatic function: mechanistically diverse superfamilies and functionally distinct suprafamilies

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Directed evolution converts subtilisin E into a functional equivalent of thermitase

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Redesigning the substrate specificity of an enzyme by cumulative effects of the mutations of non-active site residues

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Directed evolution of a thermostable esterase.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Assessing the impact of secondary structure and solvent accessibility on protein evolution.

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Engineering an enzyme to resist boiling

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Structural and genetic analysis of protein stability

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

A relationship between protein stability and protein function

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

The alpha/beta hydrolase fold

14 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Changes in the apomyoglobin folding pathway caused by mutation of the distal histidine residue

14 July 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Directed evolution of mesophilic enzymes into their thermophilic counterparts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Stabilization of hyperactive dihydrofolate reductase by cyanocysteine-mediated backbone cyclization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Relation between protein stability, evolution and structure, as probed by carboxylic acid mutations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Analysis of catalytic residues in enzyme active sites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Point mutations in protein globular domains: contributions from function, stability and misfolding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Shared promiscuous activities and evolutionary features in various members of the amidohydrolase superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Biochemistry. Loop grafting and the origins of enzyme species.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Step-wise mutation of barnase to binase. A procedure for engineering increased stability of proteins and an experimental analysis of the evolution of protein stability

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

Stability and function: two constraints in the evolution of barstar and other proteins

31 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2265470

His···Asp Catalytic Dyad of Ribonuclease A: Conformational Stability of the Wild-Type, D121N, D121A, and H119A Enzymes†

31 October 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PCBI.1000002

Conformational stability of pig citrate synthase and some active-site mutants

21 January 2018

1 reference

12 December 2020

Analysis of the steric strain in the polypeptide backbone of protein molecules

1 reference

12 December 2020

Effect of active site residues in barnase on activity and stability

1 reference

12 December 2020

Binding hot spots in the TEM1-BLIP interface in light of its modular architecture

1 reference

12 December 2020

Remarkable activity enhancement of thermolysin mutants

1 reference

12 December 2020

Surface-exposed phenylalanines in the RNP1/RNP2 motif stabilize the cold-shock protein CspB from Bacillus subtilis

1 reference

12 December 2020

10.1371/JOURNAL.PCBI.1000002

Identifiers

DOI

1 reference

journals/ploscb/TokurikiSST08

25 July 2017

1 reference

DBLP Dataset 2021-01-02

28 January 2021

1 reference

25 July 2017

1 reference