DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis (Q33586628)

28 July 2017

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title

DNA adducts of heterocyclic amine food mutagens: implications for mutagenesis and carcinogenesis (English)

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28 July 2017

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Schut HA

1

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28 July 2017

Snyderwine EG

series ordinal

2

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28 July 2017

language of work or name

English

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publication date

1 March 1999

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28 July 2017

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28 July 2017

volume

20

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28 July 2017

issue

3

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28 July 2017

page(s)

353-368

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Formation of Mutagens in Beef and Beef Extract During Cooking

28 July 2017

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Carcinogenicities of heterocyclic amines in cooked food

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Cancer risk of heterocyclic amines in cooked foods: an analysis and implications for research

21 January 2018

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Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract.

21 January 2018

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Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino-3,4-dimethylimidazo[4,5-f]quinoline

21 January 2018

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Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino-3,4-dimethylimidazo[4,5-f]quinoline

21 January 2018

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Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

21 January 2018

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Dose-response study of MeIQx carcinogenicity in F344 male rats.

21 January 2018

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Dose-dependence of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP) carcinogenicity in rats.

21 January 2018

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Induction of lymphoma in CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

21 January 2018

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DNA adducts, mutations and cancer

21 January 2018

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Metabolic activation of mutagenic heterocyclic aromatic amines from protein pyrolysates

21 January 2018

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Synthesis, purification and mutagenicity of 2-hydroxyamino-3-methylimidazolo[4,5-f]quinoline

21 January 2018

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N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver

21 January 2018

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Metabolic formation, synthesis and genotoxicity of the N-hydroxy derivative of the food mutagen 2-amino-1-methyl-6-phenylimidazo (4,5-b) pyridine (PhIP).

21 January 2018

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Metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) by liver microsomes and isolated rabbit cytochrome P450 isozymes

21 January 2018

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Microsomal metabolism of the food mutagen 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]-quinoxaline to mutagenic metabolites

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Immunological analysis of the roles of two major types of cytochrome P-450 in mutagenesis of compounds isolated from pyrolysates

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of pyrolysate arylamines by human liver microsomes; possible involvement of a P-488-H type cytochrome P-450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Activation of the food-derived mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by rabbit and human liver microsomes and purified forms of cytochrome P-450.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Genotoxicity of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP): formation of 2-hydroxamino-PhIP, a directly acting genotoxic metabolite

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Selective mutagenic activation by cytochrome P3-450 of carcinogenic arylamines found in foods

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagen activation by cDNA-expressed P(1)450, P(3)450, and P450a

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Introduction of cytochrome P450IA2 metabolic capability into cell lines genetically matched for DNA repair proficiency/deficiency

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytochrome P4501A2 constitutively expressed from transduced DNA mediates metabolic activation and DNA-adduct formation of aromatic amine carcinogens in NIH 3T3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

High promutagen activating capacity of yeast microsomes containing human cytochrome P-450 1A and human NADPH-cytochrome P-450 reductase

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Differential rates of metabolic activation and detoxication of the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine by different cytochrome P450 enzymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolism of the food derived mutagen and carcinogen 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP) by human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

The detection of promutagen activation by extracts of cells expressing cytochrome P450IA2 cDNA: preincubation dramatically increases revertant yield in the Ames test.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Procarcinogen activation by cytochrome P450 3A4 and 3A5 expressed in Escherichia coli and by human liver microsomes

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytochromes P450 in cynomolgus monkeys mutagenically activate 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) but not 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenicity and in vitro covalent DNA binding of 2-hydroxyamino-3-methylimidazolo[4,5-f]quinoline

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Activation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) to mutagenic metabolites

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon

21 January 2018

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Enzymatic phase II activation of the N-hydroxylamines of IQ, MeIQx and PhIP by various organs of monkeys and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Activation of 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b] pyridine by cDNA-expressed human and rat arylsulfotransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

N-and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenic activation of IQ, PhIP and MeIQx by hepatic microsomes from rat, monkey and man: low mutagenic activation of MeIQx in cynomolgus monkeys in vitro reflects low DNA adduct levels in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Effect of 3-methylcholanthrene induction on the distribution and DNA adduction of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in F344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Possible mechanisms for PhIP-DNA adduct formation in the mammary gland of female Sprague-Dawley rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenic activation of IQ and Me-IQ by liver and lung microsomes from rabbit and mouse, and with isolated lung cells from the rabbit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenic activation of 2-amino-3-methylimidazo[4,5-f]-quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]-quinoline (MeIQ) by subcellular fractions and cells isolated from small intestine, kidney and liver of the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytochrome P450 forms in the rodent lung involved in the metabolic activation of food-derived heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of heterocyclic amine food mutagens in the mammary gland of lactating Fischer 344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenicity of heterocyclic amines when activated by pancreas tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Prostaglandin H synthase-dependent mutagenic activation of heterocyclic aromatic amines of the IQ-type

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Prostaglandin hydroperoxidase-dependent activation of heterocyclic aromatic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Prostaglandin H synthase-dependent formation of the direct-acting mutagen 2-nitro-3-methylimidazo[4,5-f]quinoline (nitro-IQ) from IQ

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytochrome P450 dependent xenobiotic activation by physiological hydroperoxides in intact hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Hydrogen peroxide supports human and rat cytochrome P450 1A2-catalyzed 2-amino-3-methylimidazo[4,5-f]quinoline bioactivation to mutagenic metabolites: significance of cytochrome P450 peroxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of aromatic amines by human pancreas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Proliferation, development and DNA adduct levels in the mammary gland of rats given 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a high fat diet.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Synthesis and mutagenic activity of nitro-imidazoarenes. A study on the mechanism of the genotoxicity of heterocyclic arylamines and nitroarenes

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Synthesis of 2-azido-3-methylimidazo[4,5-f]quinoline and photolytic generation of a highly reactive and mutagenic IQ derivative

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Photolysis of arylazides and generation of highly electrophilic DNA-binding and mutagenic intermediates

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Azido- and nitro-PhIP, relatives of the heterocyclic arylamine and food mutagen PhIP--mechanism of their mutagenicity in Salmonella

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Quantitative structure-activity relationships of mutagenic aromatic and heteroaromatic azides and amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Use of the 32P-postlabeling method to detect DNA adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (IQ) in monkeys fed IQ: identification of the N-(deoxyguanosin-8-yl)-IQ adduct.

21 January 2018

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https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

32P-postlabeling analysis of IQ, MeIQx and PhIP adducts formed in vitro in DNA and polynucleotides and found in vivo in hepatic DNA from IQ-, MeIQx- and PhIP-treated monkeys.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Heterocyclic aromatic amine-DNA-adducts in bacteria and mammalian cells detected by 32P-postlabeling analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

The formation of heart DNA adducts in F344 rat following dietary administration of heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Identification of N-(deoxyguanosin-8-yl)-2-amino-3,4-dimethylimidazo[4,5-f]quinoline (dG-C8-MeIQ) as a major adduct formed by MeIQ with nucleotides in vitro with DNA in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

32P-adduct assay: comparative recoveries of structurally diverse DNA adducts in the various enhancement procedures

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Role of metabolism on the DNA binding of MeIQx in mice and bacteria

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

DNA adducts formed by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline in rat liver: dose-response on chronic administration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Formation and removal of DNA adducts in the liver of rats chronically fed the food-borne carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Formation of DNA adducts by the food mutagen 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinoxaline (4,8-DiMeIQx) in vitro and in vivo. Identification of a N2-(2'-deoxyguanosin-8-yl)-4,8-DiMeIQx adduct.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2'-deoxyguanosine and its phosphate esters.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Formation of DNA adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in male Fischer-344 rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Detection of guanine-C8-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adduct as a single spot on thin-layer chromatography by modification of the 32P-postlabeling method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Heterogeneous DNA adduct formation in vitro by the acetylated food mutagen 2-(acetoxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine: a fluorescence spectroscopic study

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenic activity of heterocyclic amines in cooked foods

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic conversion of IQ and MeIQ to bacterial mutagens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Reactivity and genotoxicity of arylnitrenium ions in bacterial and mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

A correlation of Salmonella mutagenicity with DNA adducts induced by the cooked-food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutagenic nitrenes/nitrenium ions from azido-imidazoarenes and their structure-activity relationships

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Quantitative structure-activity (QSAR) relationships of mutagenic aromatic and heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Relative stabilities of nitrenium ions derived from heterocyclic amine food carcinogens: relationship to mutagenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium TA98.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Specificity of base substitution mutations induced by the dietary carcinogens 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhlP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in Salmonella

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Base-change analysis of revertants of the hisD3052 allele in Salmonella typhimurium

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Analysis of mutational specificity induced by heterocyclic amines in the lacZ gene of Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutational specificity of 2-nitro-3,4-dimethylimidazo[4,5-f]quinoline in the lacI gene of Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutational and DNA binding specificity of the carcinogen 2-amino-3, 8-dimethylimidazo[4,5-f]quinoxaline.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Comparative genotoxic effects of the cooked-food-related mutagens Trp-P-2 and IQ in bacteria and cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Comparative genotoxic effects of IQ and MeIQ in Salmonella typhimurium and cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Effect of heterocyclic amines and beef extract on chromosome aberrations and sister chromatid exchanges in cultured human lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Metabolic activation and cytogenetic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b] pyridine (PhIP) in Chinese hamster ovary cells expressing murine cytochrome P450 IA2

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Genotoxicity assessment of aromatic amines and amides in genetically engineered V79 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Inhibition of plasmid reporter gene expression in CHO cells by DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutation and repair induced by the carcinogen 2-(hydroxyamino)-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP) in the dihydrofolate reductase gene of Chinese hamster ovary cells and conformational modeling of the dG-C8-PhIP adduct in DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in human lymphoblastoid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Identification of aprt gene mutations induced in repair-deficient and P450-expressing CHO cells by the food-related mutagen/carcinogen, PhIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6- phenylimidazo[4,5-b]pyridine(PhIP) at the Chinese hamsters hprt locus.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytogenetic analysis of mice chronically fed the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Cytogenetic results from a chronic feeding study of MeIQx in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

In vivo mutagenicity and DNA adduct levels of heterocyclic amines in Muta mice and c-myc/lacZ double transgenic mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Organ distinctive mutagenicity in MutaMouse after short-term exposure to PhIP.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Intestinal mutagenicity of two carcinogenic food mutagens in transgenic mice: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and amino(alpha)carboline

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Nuclear damage of colon epithelial cells by the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) is modulated by dietary lipids

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Organ-specific distribution of genotoxic effects in mice exposed to cooked food mutagens

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Induction of hepatocellular carcinoma in nonhuman primates by the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Accumulation of DNA adducts of 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in tissues and white blood cells of the Fischer-344 rat after multiple oral dosing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Sex differences in the formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

DNA adduct formation, cell proliferation and aberrant crypt focus formation induced by PhIP in male and female rat colon with relevance to carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Dose-dependent induction of 8-hydroxyguanine and preneoplastic foci in rat liver by a food-derived carcinogen, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline, at low dose levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Human exposure to carcinogenic heterocyclic amines and their mutational fingerprints in experimental animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Dietary carcinogens and mammary carcinogenesis. Induction of rat mammary carcinomas by administration of heterocyclic amines in cooked foods

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Genetic alterations in rat colon tumors induced by heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Infrequent mutation of Ha-ras and p53 in rat mammary carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Rat p53 gene mutations in primary Zymbal gland tumors induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo]4,5-b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-f]quinoline

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

p53 gene mutation in hepatocellular carcinoma induced by 2-amino-3-methylimidazo[4,5-f]quinoline in nonhuman primates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Mutational activation of c-Ha-ras gene in squamous cell carcinomas of rat Zymbal gland induced by carcinogenic heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

ras mutations in 2-amino-3-methylimidazo-[4,5-f]quinoline-induced tumors in the CDF1 mouse.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Detection of a Ha-ras point mutation by polymerase chain reaction-single strand conformation polymorphism analysis in 2-amino-3,4-dimethylimidazo[4,5-f]quinoline-induced mouse forestomach tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Rare frequency of activation of the Ki-ras gene in rat colon tumors induced by heterocyclic amines: possible alternative mechanisms of human colon carcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Evidence for ras gene mutation in 2-amino-3-methylimidazo[4,5-f]quinoline-induced colonic aberrant crypts in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Effect of dietary fat on codon 12 and 13 Ha-ras gene mutations in 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary gland tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Specific 5'-GGGA-3'-->5'-GGA-3' mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Genetic changes induced by heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Adduction of the heterocyclic amine food mutagens IQ and PhIP to mitochondrial and nuclear DNA in the liver of Fischer-344 rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Protective effect of N-acetylcysteine against heterocyclic amine-induced cardiotoxicity in cultured myocytes and in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Some perspectives on the nutritional aspects of breast cancer research. Food-derived heterocyclic amines as etiologic agents in human mammary cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Substances in human urine that strongly inhibit bacterial mutagenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and related heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Protection by chlorophyllin against the covalent binding of 2-amino-3-methylimidazo[4,5-f]qiiinoline (IQ) to rat liver DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)-DNA binding by chlorophyllin: studies of enzyme inhibition and molecular complex formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Non-specific inhibition of cytochrome P450 activities by chlorophyllin in human and rat liver microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Protection of conjugated linoleic acids against 2-amino-3- methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

DNA adducts of heterocyclic amines: formation, removal and inhibition by dietary components.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in CDF1 mice fed a high ω-3 fatty acid diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Dietary omega-3 fatty acids as potential inhibitors of carcinogenesis: effect on DNA adduct formation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mice and rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Inhibition of 2-amino-3-methylimidazo[4,5-f]quinoline-DNA adducts by indole-3-carbinol: dose-response studies in the rat colon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Inhibitory effect of dietary 4-ipomeanol on DNA adduct formation by the food mutagen 2-amino-3-methylimidazo [4,5-f]quinoline (IQ)in male CDF1 mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Effects of phenethyl isothiocyanate on metabolism and on genotoxicity of dimethylnitrosamine and 2-amino-1-methyl-6-phenylimidazo[4, 5-beta]pyridine (PhIP).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Enhancement by indole-3-carbinol of liver and thyroid gland neoplastic development in a rat medium-term multiorgan carcinogenesis model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Chemopreventive effects of beta-carotene, alpha-tocopherol and five naturally occurring antioxidants on initiation of hepatocarcinogenesis by 2-amino-3-methylimidazo[4,5-f]quinoline in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4,5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of le

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Presence of N2-(deoxyguanosin-8-yl)-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (dG-C8-MeIQx) in human tissues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Nuclease P1-mediated enhancement of sensitivity of 32P-postlabeling test for structurally diverse DNA adducts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Accelerator mass spectrometry in biomedical dosimetry: relationship between low-level exposure and covalent binding of heterocyclic amine carcinogens to DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Dose-response studies of MeIQx in rat liver and liver DNA at low doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Distribution and metabolism of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in female rats and their pups at dietary doses.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Relationship of diet to risk of colorectal adenoma in men

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Meat preparation and colorectal adenomas in a large sigmoidoscopy-based case-control study in California (United States).

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Assessment of the human exposure to heterocyclic amines

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Exposure to and activation of dietary heterocyclic amines in humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Presence of 2-amino-3,8-dimethylimidazo [4,5-f]quinoxaline (MeIQx) in dialysate from patients with uremia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Lower levels of urinary 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx) in humans with higher CYP1A2 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Heterocyclic amines formed by cooking food: comparison of bioassay results with other chemicals in the Carcinogenic Potency Database

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Biological significance of trace levels of mutagenic heterocyclic aromatic amines in human diet: a critical review

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Risk of adenocarcinoma of the stomach and esophagus with meat cooking method and doneness preference

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

Activation of heterocyclic aromatic amines by rat and human liver microsomes and by purified rat and human cytochrome P450 1A2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2F20.3.353

21 January 2018

Identifiers

DOI

10.1093/CARCIN/20.3.353

1 reference

28 July 2017

1 reference