Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents (Q33750760)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

1 reference

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Charlotte Hinault

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

author name string

Dan Kawamori

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Jiang Hu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

John Meyer

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Murtaza Kanji

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Anil Bhushan

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

Rohit N Kulkarni

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

language of work or name

English

0 references

publication date

26 January 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

number of pages

10

1 reference

inferred from page(s)

published in

Diabetes

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

volume

59

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

issue

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

page(s)

987-996

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported

17 January 2020

copyright license

start time

30 August 2021

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2844846/fullTextXML

inferred from PubMed Central ID database lookup

cites work

Cyclin D2 protein stability is regulated in pancreatic beta-cells

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Dynamics of beta-cell turnover: evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-cell replication in the HIP rat

14 July 2018

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Age-dependent decline in beta-cell proliferation restricts the capacity of beta-cell regeneration in mice

14 July 2018

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Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function

14 July 2018

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Growth factor control of pancreatic islet regeneration and function

14 July 2018

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

14 July 2018

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Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas

14 July 2018

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pdx-1 function is specifically required in embryonic beta cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

14 July 2018

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Role of FoxO Proteins in Pancreatic beta Cells

14 July 2018

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Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes

14 July 2018

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A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants

14 July 2018

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Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance

14 July 2018

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Molecular control of cell cycle progression in the pancreatic beta-cell

14 July 2018

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Cyclins D2 and D1 are essential for postnatal pancreatic beta-cell growth

14 July 2018

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Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass.

14 July 2018

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PDX-1 haploinsufficiency limits the compensatory islet hyperplasia that occurs in response to insulin resistance

14 July 2018

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Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

14 July 2018

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Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes

14 July 2018

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The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth

14 July 2018

1 reference

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Pdx1 restores beta cell function in Irs2 knockout mice

14 July 2018

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Activation of IRS-2-mediated signal transduction by IGF-1, but not TGF-alpha or EGF, augments pancreatic beta-cell proliferation

14 July 2018

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Quantitative assessment of gene targeting in vitro and in vivo by the pancreatic transcription factor, Pdx1. Importance of chromatin structure in directing promoter binding

14 July 2018

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A kinase in the life of the beta cell

14 July 2018

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Pdx1 level defines pancreatic gene expression pattern and cell lineage differentiation

14 July 2018

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Perspective: Postnatal pancreatic beta cell growth

14 July 2018

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Islet growth and development in the adult

14 July 2018

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Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

14 July 2018

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Targeted disruption of CDK4 delays cell cycle entry with enhanced p27(Kip1) activity

14 July 2018

1 reference

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Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in beta-islet cell hyperplasia

14 July 2018

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Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice

14 July 2018

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Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis

14 July 2018

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14 July 2018

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Tissue-specific deletion of the retinoblastoma protein in the pancreatic beta-cell has limited effects on beta-cell replication, mass, and function.

14 July 2018

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The cell cycle inhibitory protein p21cip is not essential for maintaining beta-cell cycle arrest or beta-cell function in vivo.

30 October 2018

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p27 Regulates the transition of beta-cells from quiescence to proliferation

30 October 2018

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p57 and Hes1 coordinate cell cycle exit with self-renewal of pancreatic progenitors

30 October 2018

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Relationship between beta-cell mass and fasting blood glucose concentration in humans

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Very slow turnover of beta-cells in aged adult mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells.

30 October 2018

1 reference

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Lilly lecture 2003: the struggle for mastery in insulin action: from triumvirate to republic

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Impact of genetic background on development of hyperinsulinemia and diabetes in insulin receptor/insulin receptor substrate-1 double heterozygous mice

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2844846

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

30 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20103709

12 December 2020

inferred from PubMed ID database lookup

Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20103709

12 December 2020

inferred from PubMed ID database lookup

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20103709

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.2337/DB09-0838

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20103709%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference