PDE5 inhibitor efficacy is estrogen dependent in female heart disease (Q33872491)

29 July 2017

title

PDE5 inhibitor efficacy is estrogen dependent in female heart disease (English)

1 reference

29 July 2017

Hideyuki Sasaki

1

1 reference

29 July 2017

Takahiro Nagayama

2

1 reference

29 July 2017

Robert M Blanton

3

1 reference

29 July 2017

Kinya Seo

4

1 reference

29 July 2017

Manling Zhang

5

1 reference

29 July 2017

Guangshuo Zhu

6

1 reference

29 July 2017

Dong I Lee

7

1 reference

29 July 2017

Djahida Bedja

8

1 reference

29 July 2017

Steven Hsu

9

1 reference

29 July 2017

Osamu Tsukamoto

10

1 reference

29 July 2017

Seiji Takashima

11

1 reference

29 July 2017

Masafumi Kitakaze

12

1 reference

29 July 2017

Michael E Mendelsohn

13

1 reference

29 July 2017

Richard H Karas

14

1 reference

29 July 2017

David A Kass

15

1 reference

29 July 2017

Eiki Takimoto

16

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29 July 2017

language of work or name

English

0 references

publication date

16 May 2014

1 reference

Journal of Clinical Investigation

29 July 2017

published in

1 reference

29 July 2017

volume

124

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29 July 2017

issue

6

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29 July 2017

page(s)

2464-2471

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Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation

29 July 2017

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1 reference

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28 July 2018

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28 July 2018

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Protein kinase g iα inhibits pressure overload-induced cardiac remodeling and is required for the cardioprotective effect of sildenafil in vivo

28 July 2018

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Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury.

28 July 2018

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Differential expression of PDE5 in failing and nonfailing human myocardium

28 July 2018

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28 July 2018

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Myocardial remodeling is controlled by myocyte-targeted gene regulation of phosphodiesterase type 5.

28 July 2018

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Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice

28 July 2018

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28 July 2018

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Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor

28 July 2018

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Phosphodiesterase-5 inhibitor, tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase g-dependent generation of hydrogen sulfide

28 July 2018

1 reference

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Heart failure in women: a need for prospective data

28 July 2018

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Estrogen contributes to gender differences in mouse ventricular repolarization

28 July 2018

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Copper-induced regression of cardiomyocyte hypertrophy is associated with enhanced vascular endothelial growth factor receptor-1 signalling pathway

28 July 2018

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The transactivating function 1 of estrogen receptor alpha is dispensable for the vasculoprotective actions of 17beta-estradiol

28 July 2018

1 reference

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Ventricular phosphodiesterase-5 expression is increased in patients with advanced heart failure and contributes to adverse ventricular remodeling after myocardial infarction in mice

28 July 2018

1 reference

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Sildenafil stops progressive chamber, cellular, and molecular remodeling and improves calcium handling and function in hearts with pre-existing advanced hypertrophy caused by pressure overload

28 July 2018

1 reference

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Regulator of G protein signaling 2 mediates cardiac compensation to pressure overload and antihypertrophic effects of PDE5 inhibition in mice

28 July 2018

1 reference

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28 July 2018

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17 Beta-estradiol differentially affects left ventricular and cardiomyocyte hypertrophy following myocardial infarction and pressure overload

28 July 2018

1 reference

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Estrogen inhibits cardiac hypertrophy: role of estrogen receptor-beta to inhibit calcineurin

28 July 2018

1 reference

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Inhibition of apoptosis-regulated signaling kinase-1 and prevention of congestive heart failure by estrogen

28 July 2018

1 reference

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Hormone replacement therapy and the cardiovascular system lessons learned and unanswered questions

28 July 2018

1 reference

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Therapeutic implications of the gender-specific aspects of cardiovascular disease

28 July 2018

1 reference

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Vascular endothelial growth factor blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload

28 July 2018

1 reference

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Function of cGMP-dependent protein kinases as revealed by gene deletion.

28 July 2018

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Phosphodiesterase-5 inhibition with sildenafil attenuates cardiomyocyte apoptosis and left ventricular dysfunction in a chronic model of doxorubicin cardiotoxicity

28 July 2018

1 reference

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Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha

28 July 2018

1 reference

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PKC-alpha regulates cardiac contractility and propensity toward heart failure

28 July 2018

1 reference

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Cardiac hypertrophy: the good, the bad, and the ugly

28 July 2018

1 reference

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Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice

28 July 2018

1 reference

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Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling

28 July 2018

1 reference

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Gq signaling in cardiac adaptation and maladaptation

28 July 2018

1 reference

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Transgenic Galphaq overexpression induces cardiac contractile failure in mice

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Androgen receptor promotes sex-independent angiogenesis in response to ischemia and is required for activation of vascular endothelial growth factor receptor signaling

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Effectiveness-based guidelines for the prevention of cardiovascular disease in women--2011 update: a guideline from the american heart association.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

PDE5 inhibition with sildenafil improves left ventricular diastolic function, cardiac geometry, and clinical status in patients with stable systolic heart failure: results of a 1-year, prospective, randomized, placebo-controlled study.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Estrogen attenuates left ventricular and cardiomyocyte hypertrophy by an estrogen receptor-dependent pathway that increases calcineurin degradation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Sildenafil inhibits beta-adrenergic-stimulated cardiac contractility in humans

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

17beta-estradiol antagonizes cardiomyocyte hypertrophy by autocrine/paracrine stimulation of a guanylyl cyclase A receptor-cyclic guanosine monophosphate-dependent protein kinase pathway

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress-induced apoptosis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Androgen receptors mediate hypertrophy in cardiac myocytes

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4089449

Long-term effects of sildenafil in a rat model of chronic mitral regurgitation: benefits of ventricular remodeling and exercise capacity

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24837433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The heart is a target organ for androgen

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24837433

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1172/JCI70731

1 reference

29 July 2017

1 reference

29 July 2017

1 reference