Chemical genetics (Q33896011)

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Language	Label	Description	Also known as
English	Chemical genetics	scientific article

Statements

scholarly article

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

Chemical genetics (English)

1 reference

Europe PubMed Central

29 July 2017

David R. Spring

object named as

David R Spring

3

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author name string

Cornelius J O'Connor

1

1 reference

Europe PubMed Central

29 July 2017

Luca Laraia

2

1 reference

Europe PubMed Central

29 July 2017

publication date

12 May 2011

1 reference

Europe PubMed Central

29 July 2017

Chemical Society Reviews

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Europe PubMed Central

29 July 2017

40

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Europe PubMed Central

29 July 2017

8

1 reference

Europe PubMed Central

29 July 2017

4332-4345

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Europe PubMed Central

29 July 2017

Mastering the chemical language of bacteria

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Inter-kingdom signalling: communication between bacteria and their hosts

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Natural products as sources of new drugs over the last 25 years

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Chemical genetics resulting from a passion for synthetic organic chemistry.

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Chemical genetics to chemical genomics: small molecules offer big insights

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Chemical genetics: ligand-based discovery of gene function

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Frontiers in chemical genetics

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Chemical genetics: adding to the developmental biology toolbox

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Chemical genomics in the global study of protein functions

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siRNAs: applications in functional genomics and potential as therapeutics

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Small RNAs: delivering the future

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Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

1 reference

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21 January 2018

Chemical genetics: elucidating biological systems with small-molecule compounds

1 reference

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Skeletal diversity via a branched pathway: efficient synthesis of 29 400 discrete, polycyclic compounds and their arraying into stock solutions.

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The concept of synthetic lethality in the context of anticancer therapy

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Combination chemical genetics

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Searching for synthetic lethality in cancer

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Systematic discovery of multicomponent therapeutics

1 reference

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Expanding the range of 'druggable' targets with natural product-based libraries: an academic perspective

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Rational methods for the selection of diverse screening compounds

1 reference

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High-throughput screening assays for the identification of chemical probes

1 reference

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21 January 2018

Biophysical techniques for ligand screening and drug design

1 reference

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Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins

1 reference

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Rapid behavior-based identification of neuroactive small molecules in the zebrafish

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A small-molecule screen identifies new functions for the plant hormone strigolactone

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Recent advances and method development for drug target identification

1 reference

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Identification of the cellular targets of bioactive small organic molecules using affinity reagents

1 reference

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Small molecule microarrays: recent advances and applications

1 reference

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A photoimmobilisation strategy that maximises exploration of chemical space in small molecule affinity selection and target discovery

1 reference

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21 January 2018

Identifying the proteins to which small-molecule probes and drugs bind in cells

1 reference

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21 January 2018

A chemical and phosphoproteomic characterization of dasatinib action in lung cancer

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Target profiling of small molecules by chemical proteomics

1 reference

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Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway.

1 reference

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

1 reference

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A survey of yeast genomic assays for drug and target discovery

1 reference

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Target identification using drug affinity responsive target stability (DARTS)

1 reference

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Reaching for high-hanging fruit in drug discovery at protein-protein interfaces

1 reference

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Principles of protein-protein interactions: what are the preferred ways for proteins to interact?

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

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Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells.

1 reference

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D-peptide inhibitors of the p53–MDM2 interaction for targeted molecular therapy of malignant neoplasms

1 reference

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An inhibitor of Bcl-2 family proteins induces regression of solid tumours

1 reference

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The global distribution of clinical episodes of Plasmodium falciparum malaria

1 reference

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The pathogenic basis of malaria

1 reference

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Is chemical genetics the new frontier for malaria biology?

1 reference

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Host-cell invasion by malaria parasites: insights from Plasmodium and Toxoplasma.

1 reference

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Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

1 reference

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Drug discovery: Priming the antimalarial pipeline.

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A multifunctional serine protease primes the malaria parasite for red blood cell invasion

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Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparum

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Thousands of chemical starting points for antimalarial lead identification

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Chemical genetics of Plasmodium falciparum

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Spiroindolones, a potent compound class for the treatment of malaria

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Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis

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Antiviral drug discovery: ten more compounds, and ten more stories (part B).

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Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

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Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

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Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase

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Hepatitis C virus NS5A: tales of a promiscuous protein

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Crystal Structure of a Novel Dimeric Form of NS5A Domain I Protein from Hepatitis C Virus

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From structure to function: new insights into hepatitis C virus RNA replication

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Cyclosporin A suppresses replication of hepatitis C virus genome in cultured hepatocytes

1 reference

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Cyclophilin B is a functional regulator of hepatitis C virus RNA polymerase

1 reference

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Development of novel antiviral therapies for hepatitis C virus

1 reference

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Chemical genetics approach to hepatitis C virus replication: cyclophilin as a target for anti-hepatitis C virus strategy

1 reference

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Emergence of chemical biology approaches to the RNAi/miRNA pathway

1 reference

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Small-molecule inhibitors of microrna miR-21 function

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Small molecule modifiers of microRNA miR-122 function for the treatment of hepatitis C virus infection and hepatocellular carcinoma

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Microbiology. Is the tide turning for new malaria medicines?

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Chemical Genetics

1 reference

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The State of the Art of Chemical Biology

1 reference

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Identifiers

10.1039/C1CS15053G

1 reference

Europe PubMed Central

29 July 2017

1 reference

Europe PubMed Central

29 July 2017

ResearchGate publication ID

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