Nucleotide metabolism, oncogene-induced senescence and cancer (Q33969333)

30 July 2017

title

Nucleotide metabolism, oncogene-induced senescence and cancer (English)

1 reference

30 July 2017

Katherine M Aird

1

1 reference

30 July 2017

Rugang Zhang

series ordinal

2

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30 July 2017

language of work or name

English

0 references

publication date

29 January 2014

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30 July 2017

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30 July 2017

volume

356

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30 July 2017

issue

2 Pt A

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30 July 2017

page(s)

204-210

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Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer

30 July 2017

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Radiochemotherapy plus 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP, NSC #663249) in advanced-stage cervical and vaginal cancers

28 July 2018

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28 July 2018

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Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion

28 July 2018

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Depletion of deoxyribonucleotide pools is an endogenous source of DNA damage in cells undergoing oncogene-induced senescence

28 July 2018

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Adults with RRM2B-related mitochondrial disease have distinct clinical and molecular characteristics.

28 July 2018

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Gene expression analysis in human breast cancer associated blood vessels

28 July 2018

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p53R2 expression as a prognostic biomarker in early stage non-small cell lung cancer

28 July 2018

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The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence

28 July 2018

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Links between metabolism and cancer

28 July 2018

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Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis

28 July 2018

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Ribonucleotide reductase inhibition restores platinum-sensitivity in platinum-resistant ovarian cancer: a Gynecologic Oncology Group Study.

28 July 2018

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Iron chelators for the treatment of cancer.

28 July 2018

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Hydroxyurea: a key player in cancer chemotherapy

28 July 2018

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Pyrimidine pool imbalance induced by BLM helicase deficiency contributes to genetic instability in Bloom syndrome

28 July 2018

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Nucleotide deficiency promotes genomic instability in early stages of cancer development

28 July 2018

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Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer

28 July 2018

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Four faces of cellular senescence.

28 July 2018

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The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer.

28 July 2018

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Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy.

28 July 2018

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A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis

28 July 2018

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A phase I/II study of GTI-2040 plus docetaxel as second-line treatment in advanced non-small cell lung cancer: a study of the PMH phase II consortium

28 July 2018

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Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response

28 July 2018

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ATR: an essential regulator of genome integrity

28 July 2018

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Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms

28 July 2018

1 reference

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A phase 2 consortium (P2C) trial of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (3-AP) for advanced adenocarcinoma of the pancreas

28 July 2018

1 reference

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DNA replication stress, genome instability and aging

28 July 2018

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DNA replication stress is a determinant of chronological lifespan in budding yeast

28 July 2018

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Cellular senescence: when bad things happen to good cells

28 July 2018

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Transgenic expression of human thymidylate synthase accelerates the development of hyperplasia and tumors in the endocrine pancreas

28 July 2018

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Oncogene-induced senescence pathways weave an intricate tapestry

28 July 2018

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

28 July 2018

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

28 July 2018

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

28 July 2018

1 reference

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Oncogene-induced cell senescence--halting on the road to cancer

28 July 2018

1 reference

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Ribonucleotide reductase inhibitors and future drug design

28 July 2018

1 reference

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Expression of p53R2 is related to prognosis in patients with esophageal squamous cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Ribonucleotide reductases

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Regulation of mammalian ribonucleotide reduction and dNTP pools after DNA damage and in resting cells

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Rothmund-Thomson syndrome and RECQL4 defect: splitting and lumping

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Overview of ribonucleotide reductase inhibitors: an appealing target in anti-tumour therapy

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Ddb1 controls genome stability and meiosis in fission yeast

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Thymidylate synthase as an oncogene: a novel role for an essential DNA synthesis enzyme

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

The serial cultivation of human diploid cell strains

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Impaired function of p53R2 in Rrm2b-null mice causes severe renal failure through attenuation of dNTP pools

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

RecQ helicases: suppressors of tumorigenesis and premature aging.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

RRM1-induced metastasis suppression through PTEN-regulated pathways

28 July 2018

1 reference

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Glutamine and glutamate--their central role in cell metabolism and function.

28 July 2018

1 reference

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Expression of p53R2, newly p53 target in oral normal epithelium, epithelial dysplasia and squamous cell carcinoma

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Checking on the fork: the DNA-replication stress-response pathway

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Triapine (3-aminopyridine-2-carboxaldehyde- thiosemicarbazone): A potent inhibitor of ribonucleotide reductase activity with broad spectrum antitumor activity.

28 July 2018

1 reference

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28 July 2018

The Hallmarks of Cancer

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Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

The regulation of E2F by pRB-family proteins

28 July 2018

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Pharmacokinetics and pharmacodynamics of hydroxyurea

28 July 2018

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The R1 component of mammalian ribonucleotide reductase has malignancy-suppressing activity as demonstrated by gene transfer experiments

28 July 2018

1 reference

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Cancer-susceptibility genes. Gatekeepers and caretakers

28 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

28 July 2018

1 reference

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Inhibition of E2F-1 transactivation by direct binding of the retinoblastoma protein

28 July 2018

1 reference

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E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product

28 July 2018

1 reference

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

28 July 2018

1 reference

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

28 July 2018

1 reference

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Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Genetic defects in human purine and pyrimidine metabolism

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

The Control of Nucleotide Biosynthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Functional regulation of mammalian ribonucleotide reductase.

28 July 2018

1 reference

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The biological significance of purine salvage

28 July 2018

1 reference

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Ribonucleotide reductase as a chemotherapeutic target

28 July 2018

1 reference

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Interactions between deoxyribonucleotide and DNA synthesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

The molecular basis of mutations induced by deoxyribonucleoside triphosphate pool imbalances in mammalian cells

28 July 2018

1 reference

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Purine nucleotide imbalance in immunodeficiency disorders

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

EPR stopped-flow studies of the reaction of the tyrosyl radical of protein R2 from ribonucleotide reductase with hydroxyurea

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

New ribonucleotide reductase inhibitors with antineoplastic activity

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Chromosomal instability triggered by Rrm2b loss leads to IL-6 secretion and plasmacytic neoplasms

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Ribonucleotide reductase small subunit M2 serves as a prognostic biomarker and predicts poor survival of colorectal cancers.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

p53R2 is a prognostic factor of melanoma and regulates proliferation and chemosensitivity of melanoma cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Management of 3-aminopyridine-2-carboxaldehyde thiosemicarbazone-induced methemoglobinemia.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Hallmarks of Cancer: The Next Generation

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

A phase II study of the antisense oligonucleotide GTI-2040 plus docetaxel and prednisone as first-line treatment in castration-resistant prostate cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Ribonucleotide reductase: a critical enzyme for cancer chemotherapy and antiviral agents

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

DNA precursor metabolism and genomic stability

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Oncogene-induced senescence as an initial barrier in lymphoma development

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Electron transfer in N-hydroxyurea complexes with iron(III).

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

RRM1 and PTEN as prognostic parameters for overall and disease-free survival in patients with non-small-cell lung cancer

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Dynamics of DNA replication in mammalian somatic cells: nucleotide pool modulates origin choice and interorigin spacing.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Mice deficient for cytosolic thymidine kinase gene develop fatal kidney disease

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: a National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Ribonucleotide reductase inhibitors: new strategies for cancer chemotherapy

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Effects of cytosine arabinoside and hydroxyurea on the synthesis of deoxyribonucleotides and DNA replication in L1210 cells

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4115046

Changes of deoxyribonucleoside triphosphate pools induced by hydroxyurea and their relation to DNA synthesis

29 October 2018

1 reference

12 December 2020

A Phase I/II study of GTI-2040 and capecitabine in patients with renal cell carcinoma

1 reference

12 December 2020

Cell cycle-dependent expression of mammalian ribonucleotide reductase. Differential regulation of the two subunits

1 reference

12 December 2020

Hydroxyurea (NSC-32065) in biologic fluids: dose-concentration relationship

1 reference

12 December 2020

Prognostic importance of thymidylate synthase expression in early breast cancer

1 reference

12 December 2020

Regulation of ribonucleotide reductase in mammalian cells by chemotherapeutic agents

1 reference

12 December 2020

Phase II study of 3-AP Triapine in patients with recurrent or metastatic head and neck squamous cell carcinoma

1 reference

12 December 2020

Prognostic significance of ERCC1, RRM1 and BRCA1 in surgically-treated patients with non-small cell lung cancer

1 reference

12 December 2020

Biochemical and antitumor activity of trimidox, a new inhibitor of ribonucleotide reductase

1 reference

12 December 2020

Nucleic Acids, Purines, Pyrimidines (Nucleotide Synthesis)

1 reference

12 December 2020

10.1016/J.CANLET.2014.01.017

Identifiers

DOI

1 reference

30 July 2017

1 reference

30 July 2017

1 reference