Targeting XIAP for the treatment of malignancy (Q33991803)

30 July 2017

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title

Targeting XIAP for the treatment of malignancy (English)

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30 July 2017

A D Schimmer

1

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30 July 2017

S Dalili

series ordinal

2

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30 July 2017

R A Batey

series ordinal

3

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30 July 2017

S J Riedl

series ordinal

4

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30 July 2017

1 February 2006

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Cell Death & Differentiation

30 July 2017

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30 July 2017

13

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30 July 2017

2

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30 July 2017

179-188

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https://scigraph.springernature.com/pub.10.1038/sj.cdd.4401826

30 July 2017

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A conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitors

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IAPs block apoptotic events induced by caspase-8 and cytochrome c by direct inhibition of distinct caspases

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7 January 2021

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

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7 January 2021

NMR structure and mutagenesis of the third Bir domain of the inhibitor of apoptosis protein XIAP

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XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

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Mechanism of XIAP-mediated inhibition of caspase-9

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Structural basis for the inhibition of caspase-3 by XIAP

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NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP

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7 January 2021

Structural basis of caspase-7 inhibition by XIAP

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7 January 2021

XIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPs.

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7 January 2021

X-linked inhibitor of apoptosis protein (XIAP) inhibits caspase-3 and -7 in distinct modes

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7 January 2021

Caenorhabditis elegans inhibitor of apoptosis protein (IAP) homologue BIR-1 plays a conserved role in cytokinesis.

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7 January 2021

Role for yeast inhibitor of apoptosis (IAP)-like proteins in cell division

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7 January 2021

Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli

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Identification of ubiquitination sites on the X-linked inhibitor of apoptosis protein

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X-linked inhibitor of apoptosis functions as ubiquitin ligase toward mature caspase-9 and cytosolic Smac/DIABLO

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Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death

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Selective activation of JNK1 is necessary for the anti-apoptotic activity of hILP.

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IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition

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Activation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1

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xIAP induces cell-cycle arrest and activates nuclear factor-kappaB : new survival pathways disabled by caspase-mediated cleavage during apoptosis of human endothelial cells

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7 January 2021

Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis

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Neurotrophin receptor-interacting mage homologue is an inducible inhibitor of apoptosis protein-interacting protein that augments cell death

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A novel role for XIAP in copper homeostasis through regulation of MURR1

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Upstream regulatory role for XIAP in receptor-mediated apoptosis

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Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells.

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7 January 2021

Downregulation of XIAP expression induces apoptosis and enhances chemotherapeutic sensitivity in human gastric cancer cells.

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7 January 2021

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death.

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7 January 2021

Downregulation of Bcl-2, FLIP or IAPs (XIAP and survivin) by siRNAs sensitizes resistant melanoma cells to Apo2L/TRAIL-induced apoptosis

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7 January 2021

Loss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeutics

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7 January 2021

Characterization of XIAP-deficient mice

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia

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7 January 2021

Caspase-independent cell death in AML: caspase inhibition in vitro with pan-caspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis

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7 January 2021

Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma.

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7 January 2021

GH3, a novel proapoptotic domain in Drosophila Grim, promotes a mitochondrial death pathway

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7 January 2021

Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins

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7 January 2021

Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition

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7 January 2021

HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins

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7 January 2021

A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death

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7 January 2021

Smac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivo.

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7 January 2021

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

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7 January 2021

Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain

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7 January 2021

Synthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situ

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7 January 2021

Structural basis of IAP recognition by Smac/DIABLO

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7 January 2021

Requirement of Both the Second and Third BIR Domains for the Relief of X-linked Inhibitor of Apoptosis Protein (XIAP)-mediated Caspase Inhibition by Smac

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Validation of pharmacodynamic assays to evaluate the clinical efficacy of an antisense compound (AEG 35156) targeted to the X-linked inhibitor of apoptosis protein XIAP.

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Structure-based design of potent, conformationally constrained Smac mimetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Antitumor, anti-inflammatory and analgesic property of embelin, a plant product

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Reversible contraception like activity of embelin in male dogs (Canis indicus Linn)

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

A JNK-Dependent Pathway Is Required for TNFα-Induced Apoptosis

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/caspase-3 interaction

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

ABL mutations in late chronic phase chronic myeloid leukemia patients with up-front cytogenetic resistance to imatinib are associated with a greater likelihood of progression to blast crisis and shorter survival: a study by the GIMEMA Working Party o

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https://api.crossref.org/works/10.1038%2FSJ.CDD.4401826

7 January 2021

Identifiers

DOI

10.1038/SJ.CDD.4401826

1 reference

30 July 2017

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