Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis (Q34010086)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11805282%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

title

Functional p53 chimeras containing the Epstein-Barr virus Gly-Ala repeat are protected from Mdm2- and HPV-E6-induced proteolysis (English)

1 reference

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6 December 2019

0 references

1 reference

5

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6 December 2019

Maria Masucci

6

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6 December 2019

Nico P. Dantuma

7

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6 December 2019

author name string

Stijn Heessen

1

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6 December 2019

Ainars Leonchiks

2

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6 December 2019

Natalia Issaeva

3

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6 December 2019

Anatoly Sharipo

4

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6 December 2019

language of work or name

English

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publication date

22 January 2002

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Proceedings of the National Academy of Sciences of the United States of America

6 December 2019

number of pages

6

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based on heuristic

inferred from page(s)

published in

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6 December 2019

volume

99

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6 December 2019

issue

3

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6 December 2019

page(s)

1532-1537

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A TSG101/MDM2 regulatory loop modulates MDM2 degradation and MDM2/p53 feedback control

6 December 2019

cites work

1 reference

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5 July 2018

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5 July 2018

Surfing the p53 network

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Opposing effects of Ras on p53: transcriptional activation of mdm2 and induction of p19ARF.

5 July 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

5 July 2018

1 reference

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Inhibition of proteasomal degradation by the gly-Ala repeat of Epstein-Barr virus is influenced by the length of the repeat and the strength of the degradation signal

5 July 2018

1 reference

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Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

5 July 2018

1 reference

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Physical association of ubiquitin ligases and the 26S proteasome

5 July 2018

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The base of the proteasome regulatory particle exhibits chaperone-like activity

5 July 2018

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Nucleotide sequences and further characterization of human papillomavirus DNA present in the CaSki, SiHa and HeLa cervical carcinoma cell lines

5 July 2018

1 reference

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Functions of the MDM2 oncoprotein

5 July 2018

1 reference

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5 July 2018

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A minimal glycine-alanine repeat prevents the interaction of ubiquitinated I kappaB alpha with the proteasome: a new mechanism for selective inhibition of proteolysis

5 July 2018

1 reference

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ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways

5 July 2018

1 reference

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Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

5 July 2018

1 reference

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Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1.

5 July 2018

1 reference

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Regulation of p53 stability by Mdm2

5 July 2018

1 reference

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p53, the cellular gatekeeper for growth and division

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122225

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122225

A 26 S protease subunit that binds ubiquitin conjugates

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122225

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

5 July 2018

1 reference

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Regulation of mdm2 expression by p53: alternative promoters produce transcripts with nonidentical translation potential

5 July 2018

1 reference

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Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1.

5 July 2018

1 reference

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DNA sequence and expression of the B95-8 Epstein-Barr virus genome.

5 July 2018

1 reference

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The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=122225

Suppression of human colorectal carcinoma cell growth by wild-type p53

5 July 2018

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Inactivation of p53 gene in human and murine osteosarcoma cells

5 July 2018

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The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

5 July 2018

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

5 July 2018

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Lessons from an age-old war.

5 July 2018

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A modified p53 overcomes mdm2-mediated oncogenic transformation: a potential cancer therapeutic agent.

21 January 2018

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Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation

29 October 2018

1 reference

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RB regulates the stability and the apoptotic function of p53 via MDM2

21 January 2018

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MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status

21 January 2018

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Human CD8+ T cell responses to EBV EBNA1: HLA class I presentation of the (Gly-Ala)-containing protein requires exogenous processing

21 January 2018

1 reference

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Sensitivity of p53 lysine mutants to ubiquitin-directed degradation targeted by human papillomavirus E6

21 January 2018

1 reference

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

1 reference

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Recognition of misfolding proteins by PA700, the regulatory subcomplex of the 26 S proteasome

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1073/PNAS.022306499

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11805282%20AND%20SRC:MED&resulttype=core&format=json

6 December 2019

0 references

1 reference

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6 December 2019

PubMed publication ID

11805282

1 reference