Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction. (Q34020776)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

Low-dose bafilomycin attenuates neuronal cell death associated with autophagy-lysosome pathway dysfunction (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

0 references

1 reference

2

1 reference

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5 February 2020

Kevin A. Roth

7

1 reference

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5 February 2020

5

Guy A Caldwell

1 reference

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5 February 2020

author name string

Violetta N Pivtoraiko

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Burton J Mader

3

1 reference

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5 February 2020

Austin M Luker

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Kim A Caldwell

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

John J Shacka

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

language of work or name

English

0 references

publication date

1 June 2010

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

Journal of Neurochemistry

5 February 2020

published in

1 reference

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5 February 2020

volume

114

1 reference

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5 February 2020

issue

4

1 reference

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5 February 2020

page(s)

1193-1204

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

5 February 2020

cites work

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VPS41, a protein involved in lysosomal trafficking, is protective in Caenorhabditis elegans and mammalian cellular models of Parkinson's disease.

5 July 2018

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Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

5 July 2018

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Role of autophagy and proteasome degradation pathways in apoptosis of PC12 cells overexpressing human alpha-synuclein

5 July 2018

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Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo.

5 July 2018

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

5 July 2018

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Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

5 July 2018

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Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

5 July 2018

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Oxidative stress and autophagy in the regulation of lysosome-dependent neuron death.

5 July 2018

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Lysosomotropic drugs inhibit maturation of transforming growth factor-beta

5 July 2018

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Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

5 July 2018

1 reference

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Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models

5 July 2018

1 reference

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Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

5 July 2018

1 reference

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The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

5 July 2018

1 reference

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Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

5 July 2018

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5 July 2018

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The autophagy-lysosomal degradation pathway: role in neurodegenerative disease and therapy.

5 July 2018

1 reference

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Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Impact of recent genetic findings in Parkinson's disease

5 July 2018

1 reference

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Autophagy, bafilomycin and cell death: the "a-B-cs" of plecomacrolide-induced neuroprotection

5 July 2018

1 reference

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

5 July 2018

1 reference

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Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons

5 July 2018

1 reference

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Lysosomal membrane permeabilization during apoptosis--involvement of Bax?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Inhibition of macroautophagy triggers apoptosis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells

5 July 2018

1 reference

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Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

5 July 2018

1 reference

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Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1.

5 July 2018

1 reference

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Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

5 July 2018

1 reference

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Processing and activation of lysosomal proteinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

The Caenorhabditis elegans dopaminergic system: opportunities for insights into dopamine transport and neurodegeneration

5 July 2018

1 reference

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Neurotoxin-induced degeneration of dopamine neurons in Caenorhabditis elegans

5 July 2018

1 reference

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Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent

5 July 2018

1 reference

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Aggregation of neurofilament and alpha-synuclein proteins in Lewy bodies: implications for the pathogenesis of Parkinson disease and Lewy body dementia

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

5 July 2018

Basic culture methods

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Genetic pharmacology: interactions between drugs and gene products in Caenorhabditis elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

A P-glycoprotein protects Caenorhabditis elegans against natural toxins

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Association of the precursor of cathepsin D with coated membranes. Kinetics and carbohydrate processing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Molecular regulation of acute ethanol-induced neuron apoptosis

5 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1111%2FJ.1471-4159.2010.06838.X

Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

The Parkinson disease-associated A30P mutation stabilizes alpha-synuclein against proteasomal degradation triggered by heme oxygenase-1 over-expression in human neuroblastoma cells.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Monitoring autophagy in mammalian cultured cells through the dynamics of LC3.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1alpha (HIF-1alpha) binding and mediates HIF-1alpha expression by bafilomycin A1.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Clearance of alpha-synuclein oligomeric intermediates via the lysosomal degradation pathway.

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

α-Synuclein Is Degraded by Both Autophagy and the Proteasome

29 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2910188

Bafilomycin A1, a specific inhibitor of vacuolar-type H(+)-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells

29 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Processing and presentation of a mycobacterial antigen 85B epitope by murine macrophages is dependent on the phagosomal acquisition of vacuolar proton ATPase and in situ activation of cathepsin D

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/20534000

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1471-4159.2010.06838.X

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20534000%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference