CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. (Q34036925)

30 July 2017

CRINEPT-TROSY NMR reveals p53 core domain bound in an unfolded form to the chaperone Hsp90. (English)

1 reference

30 July 2017

0 references

4

Alan R Fersht

1 reference

30 July 2017

Dmitry B Veprintsev

3

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author name string

Stefan Rudiger

series ordinal

1

1 reference

PubMed ID

12163643

30 July 2017

Stefan M V Freund

series ordinal

2

1 reference

PubMed ID

12163643

30 July 2017

language of work or name

English

0 references

publication date

5 August 2002

1 reference

Proceedings of the National Academy of Sciences of the United States of America

30 July 2017

1 reference

30 July 2017

99

1 reference

30 July 2017

17

1 reference

30 July 2017

11085-11090

1 reference

Hsp90 inhibitors as novel cancer chemotherapeutic agents

30 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Therapeutic exploitation of the p53 pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Rescuing the function of mutant p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Structure, function, and mechanism of the Hsp90 molecular chaperone

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Co-chaperones Bag-1, Hop and Hsp40 regulate Hsc70 and Hsp90 interactions with wild-type or mutant p53.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Hsp70 interactions with the p53 tumour suppressor protein

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Hsp90: chaperoning signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Polypeptide release by Hsp90 involves ATP hydrolysis and is enhanced by the co-chaperone p23.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

TROSY and CRINEPT: NMR with large molecular and supramolecular structures in solution.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

New approaches to understanding p53 gene tumor mutation spectra

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

DT-Diaphorase expression and tumor cell sensitivity to 17-allylamino, 17-demethoxygeldanamycin, an inhibitor of heat shock protein 90

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

p53 and human cancer: the first ten thousand mutations.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

GroEL recognises sequential and non-sequential linear structural motifs compatible with extended beta-strands and alpha-helices

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Disruption of functions of wild-type p53 by hetero-oligomerization.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Hot-spot mutants of p53 core domain evince characteristic local structural changes.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Molecular chaperones: the busy life of Hsp90.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Polarization transfer by cross-correlated relaxation in solution NMR with very large molecules

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

How p53 binds DNA as a tetramer

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Thermodynamic stability of wild-type and mutant p53 core domain

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Attenuated T2 relaxation by mutual cancellation of dipole-dipole coupling and chemical shift anisotropy indicates an avenue to NMR structures of very large biological macromolecules in solution

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

A structural model for GroEL-polypeptide recognition

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Mutant conformation of p53 translated in vitro or in vivo requires functional HSP90.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Transient interaction of Hsp90 with early unfolding intermediates of citrate synthase. Implications for heat shock in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=123214

Tumor-specific mutations in p53: the acid test

5 July 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163643

12 December 2020

inferred from PubMed ID database lookup

NMR analysis of the binding of a rhodanese peptide to a minichaperone in solution

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163643

12 December 2020

inferred from PubMed ID database lookup

The importance of ATP binding and hydrolysis by hsp90 in formation and function of protein heterocomplexes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/12163643

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1073/PNAS.132393699

1 reference

release_ldyhfmu4bbakvacituvnn4biue

30 July 2017

0 references

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/ldyhfmu4bbakvacituvnn4biue

24 November 2022

mapped directly with Wikidata item

PMCID

123214

1 reference

30 July 2017

1 reference

PubMed ID

12163643