The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection (Q34079012)

30 July 2017

The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection (English)

1 reference

30 July 2017

Ring finger protein 8

1 reference

Protection of telomeres 1A

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author name string

Rekha Rai

1

1 reference

30 July 2017

Ju-Mei Li

2

1 reference

30 July 2017

Hong Zheng

3

1 reference

30 July 2017

Gabriel Tsz-Mei Lok

4

1 reference

30 July 2017

Yu Deng

5

1 reference

30 July 2017

Michael S-Y Huen

6

1 reference

30 July 2017

Junjie Chen

7

1 reference

30 July 2017

Jianping Jin

8

1 reference

30 July 2017

Sandy Chang

9

1 reference

30 July 2017

20 November 2011

1 reference

Nature Structural & Molecular Biology

30 July 2017

1 reference

30 July 2017

18

1 reference

30 July 2017

12

1 reference

30 July 2017

1400-1407

1 reference

https://scigraph.springernature.com/pub.10.1038/nsmb.2172

30 July 2017

0 references

cites work

Differential regulation of RNF8-mediated Lys48- and Lys63-based poly-ubiquitylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

The ubiquitous role of ubiquitin in the DNA damage response

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

CRL4(Cdt2)-mediated destruction of the histone methyltransferase Set8 prevents premature chromatin compaction in S phase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Structural basis of selective ubiquitination of TRF1 by SCFFbx4

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Telomere protection by TPP1 is mediated by POT1a and POT1b

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Gcn5 and SAGA regulate shelterin protein turnover and telomere maintenance.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Ubiquitin Ligase RLIM Modulates Telomere Length Homeostasis through a Proteolysis of TRF1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Tpp1/Acd maintains genomic stability through a complex role in telomere protection

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Defects in XRCC4 and KU80 differentially affect the joining of distal nonhomologous ends

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

The DNA damage response: ten years after

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Formation of NHEJ-derived reciprocal chromosomal translocations does not require Ku70.

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Telomere protection by mammalian Pot1 requires interaction with Tpp1

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Ubiquitin ligases: cell-cycle control and cancer

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

The F-box protein FBX4 targets PIN2/TRF1 for ubiquitin-mediated degradation and regulates telomere maintenance

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

A proteomics approach to understanding protein ubiquitination

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

Regulation of E2F through ubiquitin-proteasome-dependent degradation: stabilization by the pRB tumor suppressor protein

28 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3657743

How shelterin solves the telomere end-protection problem

28 July 2018

1 reference

The POT1-TPP1 telomere complex is a telomerase processivity factor

21 January 2018

1 reference

Multiple roles for MRE11 at uncapped telomeres

21 January 2018

1 reference

Cathepsin L activity controls adipogenesis and glucose tolerance

21 January 2018

1 reference

The RING finger protein RNF8 recruits UBC13 for lysine 63-based self polyubiquitylation

21 January 2018

1 reference

DNA-damage response and repair activities at uncapped telomeres depend on RNF8

21 January 2018

1 reference

Dual E1 activation systems for ubiquitin differentially regulate E2 enzyme charging

21 January 2018

1 reference

Regulation of DNA repair by ubiquitylation

21 January 2018

1 reference

TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

21 January 2018

1 reference

Positive feedback between p53 and TRF2 during telomere-damage signalling and cellular senescence.

21 January 2018

1 reference

Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis

21 January 2018

1 reference

Probing the telomere damage response

21 January 2018

1 reference

Cytogenetic analysis of telomere dysfunction

21 January 2018

1 reference

Telomeric damage in early stage of chronic lymphocytic leukemia correlates with shelterin dysregulation

21 January 2018

1 reference

Role for the BRCA1 C-terminal repeats (BRCT) protein 53BP1 in maintaining genomic stability

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NSMB.2172

1 reference

30 July 2017

1 reference

30 July 2017

1 reference