Radiation-induced cell death mechanisms (Q34116777)

31 July 2017

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title

Radiation-induced cell death mechanisms (English)

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31 July 2017

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David Eriksson

1

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PubMed ID

20490962

31 July 2017

Torgny Stigbrand

series ordinal

2

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31 July 2017

20 May 2010

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31 July 2017

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31 July 2017

31

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31 July 2017

363-372

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31 July 2017

4

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https://scigraph.springernature.com/pub.10.1007/s13277-010-0042-8

31 July 2017

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cites work

A dominant role for p53-dependent cellular senescence in radiosensitization of human prostate cancer cells.

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

p53: guardian of the genome and policeman of the oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

p53 induced growth arrest versus apoptosis and its modulation by survival cytokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

P53 promoter selection: choosing between life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Radiation-induced apoptosis: relevance to radiotherapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Combined low dose radio- and radioimmunotherapy of experimental HeLa Hep 2 tumours.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Involvement of centrosome amplification in radiation-induced mitotic catastrophe

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Cytostatic activity of paclitaxel in coronary artery smooth muscle cells is mediated through transient mitotic arrest followed by permanent post-mitotic arrest: comparison with cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Preferential killing of tetraploid tumor cells by targeting the mitotic kinesin Eg5.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS13277-010-0042-8

Transcriptional regulation by p53: one protein, many possibilities

21 January 2018

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12 December 2020

Molecular mechanisms of caspase regulation during apoptosis

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12 December 2020

Chromosome segregation and cancer: cutting through the mystery

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12 December 2020

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

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12 December 2020

Constitutive p38HOG mitogen-activated protein kinase activation induces permanent cell cycle arrest and senescence

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12 December 2020

Aurora kinase inhibitors

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12 December 2020

Adriamycin-induced senescence in breast tumor cells involves functional p53 and telomere dysfunction

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12 December 2020

Identification of a p53-dependent negative response element in the bcl-2 gene

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12 December 2020

Assessing TP53 status in human tumours to evaluate clinical outcome

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12 December 2020

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12 December 2020

The senescence-associated secretory phenotype: the dark side of tumor suppression

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12 December 2020

Aurora kinases as anticancer drug targets

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12 December 2020

Hallmarks of senescence in carcinogenesis and cancer therapy

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12 December 2020

Origins of G1 arrest in senescent human fibroblasts

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12 December 2020

Induction of centrosome amplification in p53 siRNA-treated human fibroblast cells by radiation exposure

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12 December 2020

[Mitotic catastrophe: a special case of apoptosis]

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12 December 2020

Limiting the proliferation of polyploid cells

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12 December 2020

p16 INK4a can initiate an autonomous senescence program

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12 December 2020

Thymocyte apoptosis induced by p53-dependent and independent pathways.

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12 December 2020

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

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12 December 2020

Awakening guardian angels: drugging the p53 pathway

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12 December 2020

Down-regulation of bcl-2 by p53 in breast cancer cells.

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12 December 2020

Role of p53 in regulating constitutive and X-radiation-inducible CD95 expression and function in carcinoma cells

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12 December 2020

p53-Dependent accelerated senescence induced by ionizing radiation in breast tumour cells

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12 December 2020

DNA damage induces Chk1-dependent centrosome amplification.

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12 December 2020

G2 checkpoint abrogators as anticancer drugs

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12 December 2020

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

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12 December 2020

Induction of bax by genotoxic stress in human cells correlates with normal p53 status and apoptosis

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12 December 2020

KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

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12 December 2020

Up-regulation of Fas (CD95) in human p53wild-type cancer cells treated with ionizing radiation

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12 December 2020

Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers.

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12 December 2020

Death and anti-death: tumour resistance to apoptosis

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12 December 2020

Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging

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12 December 2020

The p53 pathway: positive and negative feedback loops

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12 December 2020

Cancer. p53, guardian of the genome

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12 December 2020

Centrosome hyperamplification and chromosomal damage after exposure to radiation

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12 December 2020

Survivin: key regulator of mitosis and apoptosis and novel target for cancer therapeutics

1 reference

12 December 2020

Apoptotic signalling in HeLa Hep2 cells following 5 Gy of cobalt-60 gamma radiation.

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12 December 2020

Radiation-induced apoptosis

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12 December 2020

Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

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12 December 2020

p53 is required for radiation-induced apoptosis in mouse thymocytes

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12 December 2020

p53 in growth control and neoplasia

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12 December 2020

Iodine-131 induces mitotic catastrophes and activates apoptotic pathways in HeLa Hep2 cells

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12 December 2020

Caspase-2 function in response to DNA damage

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12 December 2020

Oncology. Recruiting the cell's own guardian for cancer therapy.

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12 December 2020

Two CD95 (APO-1/Fas) signaling pathways

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12 December 2020

Decoding the links between mitosis, cancer, and chemotherapy: The mitotic checkpoint, adaptation, and cell death.

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12 December 2020

Oncogenes and tumour suppressors take on centrosomes

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12 December 2020

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

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12 December 2020

Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

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12 December 2020

Inhibition of tumor angiogenesis by p53: a new role for the guardian of the genome.

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12 December 2020

Induction of accelerated senescence by gamma radiation in human solid tumor-derived cell lines expressing wild-type TP53.

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12 December 2020

Structural and functional basis for therapeutic modulation of p53 signaling.

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12 December 2020

Cytokine expression and signaling in drug-induced cellular senescence.

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12 December 2020

Desmoid tumors in adults: the role of radiotherapy in their management

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12 December 2020

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

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12 December 2020

p53 mutations in human cancers

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12 December 2020

How does radiation kill cells?

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12 December 2020

Prediction of radiosensitivity of oral cancers by serial cytological assay of nuclear changes

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12 December 2020

The expanding role of mitochondria in apoptosis

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12 December 2020

Cell death modalities: classification and pathophysiological implications

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12 December 2020

p53 modulation of the DNA damage response

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12 December 2020

Puma is an essential mediator of p53-dependent and -independent apoptotic pathways

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12 December 2020

Lack of p53 function promotes radiation-induced mitotic catastrophe in mouse embryonic fibroblast cells

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12 December 2020

Overview of cell death signaling pathways

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12 December 2020

Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent

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12 December 2020

Effects of the multidrug transporter P-glycoprotein on cellular responses to ionizing radiation

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12 December 2020

Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

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12 December 2020

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

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12 December 2020

Structure meets function--centrosomes, genome maintenance and the DNA damage response

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12 December 2020

Senescence in tumours: evidence from mice and humans

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12 December 2020

Two faces of p53: aging and tumor suppression

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12 December 2020

Cytochrome c promotes caspase-9 activation by inducing nucleotide binding to Apaf-1

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12 December 2020

BH3-only proteins Puma and Bim are rate-limiting for gamma-radiation- and glucocorticoid-induced apoptosis of lymphoid cells in vivo.

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12 December 2020

Apoptosis: controlled demolition at the cellular level

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12 December 2020

A comprehensive study of p53 transcriptional activity in thymus and spleen of gamma irradiated mouse: high sensitivity of genes involved in the two main apoptotic pathways.

1 reference

12 December 2020

Reasons to reconsider the significance of apoptosis for cancer therapy

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12 December 2020

Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo.

1 reference

12 December 2020

p53 mutation heterogeneity in cancer

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12 December 2020

Restoration of p53 to limit tumor growth

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12 December 2020

Radiation-induced acute immediate nuclear abnormalities in oral cancer cells: serial cytologic evaluation

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12 December 2020

Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin

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12 December 2020

The serial cultivation of human diploid cell strains

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12 December 2020

Segregation of genomes in polyploid tumour cells following mitotic catastrophe.

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12 December 2020

Expression and regulation of Bcl-2, Bcl-xl, and Bax correlate with p53 status and sensitivity to apoptosis in childhood acute lymphoblastic leukemia

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12 December 2020

Telomere dysfunction and tumour suppression: the senescence connection

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12 December 2020

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

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12 December 2020

Tetraploidy, aneuploidy and cancer

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12 December 2020

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

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12 December 2020

Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

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12 December 2020

Cell cycle kinases as therapeutic targets for cancer

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12 December 2020

P53, cyclin-dependent kinase and abnormal amplification of centrosomes

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12 December 2020

Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

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12 December 2020

From polyploidy to aneuploidy, genome instability and cancer

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12 December 2020

In several cell types tumour suppressor p53 induces apoptosis largely via Puma but Noxa can contribute

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12 December 2020

Cell death by mitotic catastrophe: a molecular definition

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12 December 2020

p53-dependent and -independent regulation of the death receptor KILLER/DR5 gene expression in response to genotoxic stress and tumor necrosis factor alpha

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12 December 2020

New concepts in radiation-induced apoptosis: 'premitotic apoptosis' and 'postmitotic apoptosis'.

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12 December 2020

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

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12 December 2020

Apoptosis regulation in tetraploid cancer cells

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12 December 2020

DNA damage induces a novel p53-survivin signaling pathway regulating cell cycle and apoptosis in acute lymphoblastic leukemia cells

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12 December 2020

Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment

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12 December 2020

p16/MTS1/INK4A suppresses prostate cancer by both pRb dependent and independent pathways

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12 December 2020

On the TRAIL from p53 to apoptosis?

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12 December 2020

Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation

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12 December 2020

Living with p53, dying of p53.

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12 December 2020

Mitotic catastrophe constitutes a special case of apoptosis whose suppression entails aneuploidy.

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12 December 2020

Cellular senescence and cancer treatment.

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12 December 2020

Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing radiation.

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12 December 2020

Tumor cell senescence in cancer treatment

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12 December 2020

Radiation response of cell organelles

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12 December 2020

p53-independent apoptosis and p53-dependent block of DNA rereplication following mitotic spindle inhibition in human cells.

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12 December 2020

P53 and radiation responses

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12 December 2020

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

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12 December 2020

Radiation response of mouse lymphoid and myeloid cell lines. Part II. Apoptotic death is shown by all lines examined

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12 December 2020

Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors

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12 December 2020

Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening

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12 December 2020

Stuck in division or passing through: what happens when cells cannot satisfy the spindle assembly checkpoint

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12 December 2020

The role of p53 in determining sensitivity to radiotherapy

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12 December 2020

DNA damage-induced apoptosis

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12 December 2020

Fas is involved in the p53-dependent apoptotic response to ionizing radiation in mouse testis

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12 December 2020

Do prostatic biopsies 12 months or more after external irradiation for adenocarcinoma, Stage III, predict long-term survival?

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12 December 2020

An accelerated senescence response to radiation in wild-type p53 glioblastoma multiforme cells

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12 December 2020

The identification of senescence-specific genes during the induction of senescence in prostate cancer cells

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12 December 2020

Caspase-9 and APAF-1 form an active holoenzyme

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12 December 2020

Cell cycle progression after cleavage failure: mammalian somatic cells do not possess a "tetraploidy checkpoint".

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12 December 2020

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53.

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12 December 2020

Spindle checkpoint function and cellular sensitivity to antimitotic drugs

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12 December 2020

Cancer: a matter of life cycle?

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12 December 2020

p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa

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12 December 2020

10.1007/S13277-010-0042-8

Identifiers

DOI

1 reference

PubMed ID

20490962

Dimensions Publication ID

31 July 2017

0 references

1 reference

PubMed ID

20490962