Concepts in Ras-directed therapy (Q34119565)

31 July 2017

Concepts in Ras-directed therapy (English)

1 reference

31 July 2017

Kloog Y

1

1 reference

31 July 2017

Cox AD

series ordinal

2

1 reference

31 July 2017

Sinensky M

series ordinal

3

1 reference

31 July 2017

language of work or name

English

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publication date

1 December 1999

1 reference

Expert Opinion on Investigational Drugs

31 July 2017

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31 July 2017

8

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31 July 2017

12

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31 July 2017

2121-2140

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Proteins regulating Ras and its relatives

31 July 2017

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Function and regulation of ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Growth factor signaling by receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Increasing complexity of the Ras signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Ras-GRF activates Ha-Ras, but not N-Ras or K-Ras 4B, protein in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Ha-ras and N-ras regulate MAPK activity by distinct mechanisms in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Ras signalling and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Growth factor receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Regulation of tyrosine kinase cascades by G-protein-coupled receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Production of transforming growth factor alpha in human pancreatic cancer cells: evidence for a superagonist autocrine cycle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The GTPase superfamily: conserved structure and molecular mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

p21ras is modified by a farnesyl isoprenoid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

All ras proteins are polyisoprenylated but only some are palmitoylated

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Specific isoprenoid modification is required for function of normal, but not oncogenic, Ras protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The structural basis of the activation of Ras by Sos

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

GTPase-activating proteins: helping hands to complement an active site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Guanosine triphosphatase stimulation of oncogenic Ras mutants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Multiple Ras functions can contribute to mammalian cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Role of phosphoinositide 3-OH kinase in cell transformation and control of the actin cytoskeleton by Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Stimulation of membrane ruffling and MAP kinase activation by distinct effectors of RAS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Raf meets Ras: completing the framework of a signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

How MAP kinases are regulated

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The stress-activated protein kinase subfamily of c-Jun kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Regulation of recombinant MEK1 and MEK2b expressed in Escherichia coli.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

PDGF stimulates an increase in GTP-Rac via activation of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Regulation of Ras-mediated signalling: more than one way to skin a cat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Requirement of NF-kappaB activation to suppress p53-independent apoptosis induced by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Involvement of Ral GTPase in v-Src-induced phospholipase D activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

An essential role for Rac in Ras transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Signaling networks--do all roads lead to the same genes?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Synergy between the Mos/mitogen-activated protein kinase pathway and loss of p53 function in transformation and chromosome instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Modulation of Ras and a-factor function by carboxyl-terminal proteolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Farnesyl derivatives of rigid carboxylic acids-inhibitors of ras-dependent cell growth

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Chemical biology of protein isoprenylation/methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Chemical biology of isoprenylation/methylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Stringent structural requirements for anti-Ras activity of S-prenyl analogues

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Protein prenylation: from discovery to prospects for cancer treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The potential of farnesyltransferase inhibitors as cancer chemotherapeutics

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Hydroxamic acid-based bisubstrate analog inhibitors of Ras farnesyl protein transferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

C-terminal modifications of histidyl-N-benzylglycinamides to give improved inhibition of Ras farnesyltransferase, cellular activity, and anticancer activity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

v-K-ras leads to preferential farnesylation of p21(ras) in FRTL-5 cells: multiple interference with the isoprenoid pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Physical association with ras enhances activation of membrane-bound raf (RafCAAX).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Activation of the cellular proto-oncogene product p21Ras by addition of a myristylation signal

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Evidence for a high affinity, saturable, prenylation-dependent p21Ha-ras binding site in plasma membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Cholesterol depletion of caveolae causes hyperactivation of extracellular signal-related kinase (ERK).

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

The caveolae membrane system

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Reduction of caveolin and caveolae in oncogenically transformed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Membrane interactions of a constitutively active GFP-Ki-Ras 4B and their role in signaling. Evidence from lateral mobility studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Spatial dynamics of GFP-tagged proteins investigated by local fluorescence enhancement

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

K-ras is an essential gene in the mouse with partial functional overlap with N-ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Selective inhibition of Ras-dependent cell growth by farnesylthiosalisylic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Dislodgment and accelerated degradation of Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Growth inhibition of ras-dependent tumors in nude mice by a potent ras-dislodging antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Contribution of Src and Ras pathways in FGF-2 induced endothelial cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Peptides containing a consensus Ras binding sequence from Raf-1 and theGTPase activating protein NF1 inhibit Ras function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Tools of the trade: use of dominant-inhibitory mutants of Ras-family GTPases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

Reovirus therapy of tumors with activated Ras pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

A new functional Ras antagonist inhibits human pancreatic tumor growth in nude mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.8.12.2121

10.1517/13543784.8.12.2121

21 January 2018

Identifiers

DOI

1 reference

31 July 2017

1 reference