Natural products as targeted modulators of the nuclear factor-kappaB pathway (Q34127458)

31 July 2017

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title

Natural products as targeted modulators of the nuclear factor-kappaB pathway (English)

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31 July 2017

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2

Michael Heinrich

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31 July 2017

Paul Bremner

1

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31 July 2017

1 April 2002

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Journal of Pharmacy and Pharmacology

31 July 2017

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31 July 2017

54

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31 July 2017

453-472

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31 July 2017

4

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Toll-like receptors: critical proteins linking innate and acquired immunity

31 July 2017

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Tumor necrosis factor receptor-associated factors (TRAFs)--a family of adapter proteins that regulates life and death

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Natural product drug discovery and development: new perspectives on international collaboration

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Signal transduction by tumor necrosis factor and its relatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Structure-cytotoxicity relationships of some helenanolide-type sesquiterpene lactones

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The nuclear factor kappa B (NF-kappa B): a potential therapeutic target for estrogen receptor negative breast cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Sp1 and krüppel-like factor family of transcription factors in cell growth regulation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Nahua indian medicinal plants (Mexico): Inhibitory activity on NF-κB as an anti-inflammatory model and antibacterial effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Hypericin as a non-antioxidant inhibitor of NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB activation in response to toxical and therapeutical agents: role in inflammation and cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Vitamin C inhibits NF-kappa B activation by TNF via the activation of p38 mitogen-activated protein kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Oxidative stress and nuclear factor-kappaB activation: a reassessment of the evidence in the light of recent discoveries.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Tumor necrosis factor receptor-associated factors (TRAFs)

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TRAF6 is a signal transducer for interleukin-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of the nuclear factor kappa B (NF-kappa B) pathway by tetracyclic kaurene diterpenes in macrophages. Specific effects on NF-kappa B-inducing kinase activity and on the coordinate activation of ERK and p38 MAPK.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Wogonin, baicalin, and baicalein inhibition of inducible nitric oxide synthase and cyclooxygenase-2 gene expressions induced by nitric oxide synthase inhibitors and lipopolysaccharide

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Effect of bioflavonoids extracted from the bark of Pinus maritima on proinflammatory cytokine interleukin-1 production in lipopolysaccharide-stimulated RAW 264.7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

FLASH coordinates NF-kappa B activity via TRAF2

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

How can we prevent cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Effects of silymarin on the acute stage of the trinitrobenzenesulphonic acid model of rat colitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Involvement of NF-kappaB in the regulation of cyclooxygenase-2 protein expression in LPS-stimulated J774 macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Prostaglandins prevent inducible nitric oxide synthase protein expression by inhibiting nuclear factor-kappaB activation in J774 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of NOS-2 expression in macrophages through the inactivation of NF-kappaB by andalusol.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The triterpenoid quinonemethide pristimerin inhibits induction of inducible nitric oxide synthase in murine macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Structural requirements of sesquiterpene lactones to inhibit LPS-induced nitric oxide synthesis in RAW 264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of NF-kappa B activation by panepoxydone

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The death domain: a module shared by proteins with diverse cellular functions.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Novel quinone methides from Salacia kraussii with in vitro antimalarial activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Redox signals and NF-kappaB activation in T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Ergolide, sesquiterpene lactone from Inula britannica, inhibits inducible nitric oxide synthase and cyclo-oxygenase-2 expression in RAW 264.7 macrophages through the inactivation of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), inhibit activation of nuclear factor-kappaB by inhibiting both its nuclear localization and ability to bind DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Ethnopharmacology in drug discovery: an analysis of its role and potential contribution

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Ethnopharmacology of Mexican asteraceae (Compositae).

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Nuclear factor-kappa B activity and intestinal inflammation in dextran sulphate sodium (DSS)-induced colitis in mice is suppressed by gliotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Phylogenetic perspectives in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Activation of NF-kappaB by FADD, Casper, and caspase-8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

A nuclear export signal in the N-terminal regulatory domain of IkappaBalpha controls cytoplasmic localization of inactive NF-kappaB/IkappaBalpha complexes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Kaurane diterpenes from Isodon japonicus inhibit nitric oxide and prostaglandin E2 production and NF-kappaB activation in LPS-stimulated macrophage RAW264.7 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Toll receptors in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TAK1 mediates an activation signal from toll-like receptor(s) to nuclear factor-kappaB in lipopolysaccharide-stimulated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The IKK complex: an integrator of all signals that activate NF-kappaB?

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

AP-1 function and regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of NF-kappaB activity enhances TRAIL mediated apoptosis in breast cancer cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Upstream NF-kappaB site is required for the maximal expression of mouse inducible nitric oxide synthase gene in interferon-gamma plus lipopolysaccharide-induced RAW 264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Suppression by a sesquiterpene lactone from Carpesium divaricatum of inducible nitric oxide synthase by inhibiting nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The plant flavonoid wogonin suppresses death of activated C6 rat glial cells by inhibiting nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of NF-kappa B by sodium salicylate and aspirin

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-kappaB activation, IkappaB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The anti-inflammatory natural product parthenolide from the medicinal herb Feverfew directly binds to and inhibits IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Activation of IkappaB kinase beta by protein kinase C isoforms

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

A review of cancer chemopreventive agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Physiological significance of STAT proteins: investigations through gene disruption in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Resveratrol suppresses TNF-induced activation of nuclear transcription factors NF-kappa B, activator protein-1, and apoptosis: potential role of reactive oxygen intermediates and lipid peroxidation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Anti-inflammatory and spasmolytic activity of extracts from Droserae herba

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB activation provides the potential link between inflammation and hyperplasia in the arthritic joint

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Anti-inflammatory and immunomodulating properties of a sterol fraction from Sideritis foetens Clem.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Evidence for involvement of NF-kappaB in the transcriptional control of COX-2 gene expression by IL-1beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The Toll/interleukin-1 receptor domain: a molecular switch for inflammation and host defence

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Hypoestoxide, a novel anti-inflammatory natural diterpene, inhibits the activity of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Caffeic acid phenethyl ester induces leukocyte apoptosis, modulates nuclear factor-kappa B and suppresses acute inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Comparative studies on the suppression of nitric oxide synthase by curcumin and its hydrogenated metabolites through down-regulation of IkappaB kinase and NFkappaB activation in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Suppression of lipopolysaccharide-induced nuclear factor-kappaB activity by theaflavin-3,3'-digallate from black tea and other polyphenols through down-regulation of IkappaB kinase activity in macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Activity of monomeric, dimeric, and trimeric flavonoids on NO production, TNF-alpha secretion, and NF-kappaB-dependent gene expression in RAW 264.7 macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

IKKepsilon is part of a novel PMA-inducible IkappaB kinase complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proinflammatory transcription factor NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Selective inhibition of NF-kappaB activation by the flavonoid hepatoprotector silymarin in HepG2. Evidence for different activating pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Antiinflammatory actions of cat's claw: the role of NF-kappaB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB/rel/IkappaB: implications in gastrointestinal diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

I kappa B-independent control of NF-kappa B activity by modulatory phosphorylations

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Oxidative stress interference with the nuclear factor-kappa B activation pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Apoptosis signaling by death receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

IKK-i, a novel lipopolysaccharide-inducible kinase that is related to IkappaB kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-kappa b-inducing kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB signaling pathways in mammalian and insect innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Cell-specific association and shuttling of IkappaBalpha provides a mechanism for nuclear NF-kappaB in B lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NAK is an IkappaB kinase-activating kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Suppression of TNF-alpha-induced apoptosis by NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Inhibition of TNF-induced apoptosis by NF-kappa B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Regulation of NF-?B activity in murine macrophages: Effect of bacterial lipopolysaccharide and phorbol ester

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Gliotoxin and related epipolythiodioxopiperazines

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

NF-kappa B-mediated chemoresistance in breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Resolution of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Cytotoxicity of flavonoids and sesquiterpene lactones from Arnica species against the GLC4 and the COLO 320 cell lines.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Therapeutic potential of inhibition of the NF-kappaB pathway in the treatment of inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

TNFR-associated factor family protein expression in normal tissues and lymphoid malignancies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Mitogen-activated protein kinase/ERK kinase kinases 2 and 3 activate nuclear factor-kappaB through IkappaB kinase-alpha and IkappaB kinase-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Gliotoxin-induced cytotoxicity proceeds via apoptosis and is mediated by caspases and reactive oxygen species in LLC-PK1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1211%2F0022357021778637

Andalusol, a diterpenoid with anti-inflammatory activity from Siderits foetens Clemen

21 January 2018

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.1515/ZNC-1997-11-1219

Identifiers

DOI

10.1211/0022357021778637

1 reference

31 July 2017

1 reference

PubMed ID

11999122