Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis (Q34136234)

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English	Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis	scientific article

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scholarly article

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Europe PubMed Central

31 July 2017

Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: implications for cell proliferation and tumorigenesis (English)

1 reference

Europe PubMed Central

31 July 2017

author name string

M D Lacher

1

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Europe PubMed Central

31 July 2017

R Pincheira

2

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Europe PubMed Central

31 July 2017

Z Zhu

3

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Europe PubMed Central

31 July 2017

B Camoretti-Mercado

4

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Europe PubMed Central

31 July 2017

M Matli

5

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Europe PubMed Central

31 July 2017

R S Warren

6

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Europe PubMed Central

31 July 2017

A F Castro

7

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Europe PubMed Central

31 July 2017

language of work or name

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publication date

6 September 2010

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Europe PubMed Central

31 July 2017

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Europe PubMed Central

31 July 2017

29

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Europe PubMed Central

31 July 2017

50

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Europe PubMed Central

31 July 2017

6543-6556

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Europe PubMed Central

31 July 2017

https://scigraph.springernature.com/pub.10.1038/onc.2010.393

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Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

21 January 2018

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

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https://api.crossref.org/works/10.1038%2FONC.2010.393

21 January 2018

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancer

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https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Stopping and going with p27kip1.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Molecular genetic advances in tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

TORgeting oncogene addiction for cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

mTOR and cancer therapy

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Mutation in TSC2 and activation of mammalian target of rapamycin signalling pathway in renal angiomyolipoma

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Farnesyltransferase inhibitors reverse altered growth and distribution of actin filaments in Tsc-deficient cells via inhibition of both rapamycin-sensitive and -insensitive pathways

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

AMPK phosphorylation of raptor mediates a metabolic checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Akt activates the mammalian target of rapamycin by regulating cellular ATP level and AMPK activity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

The TSC1-TSC2 complex: a molecular switchboard controlling cell growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Signaling events downstream of mammalian target of rapamycin complex 2 are attenuated in cells and tumors deficient for the tuberous sclerosis complex tumor suppressors

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Tuberous sclerosis complex, implication from a rare genetic disease to common cancer treatment

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

TSC2 mediates cellular energy response to control cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Akt activity negatively regulates phosphorylation of AMP-activated protein kinase in the heart

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Identification of S664 TSC2 phosphorylation as a marker for extracellular signal-regulated kinase mediated mTOR activation in tuberous sclerosis and human cancer.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

AMP-activated protein kinase promotes human prostate cancer cell growth and survival

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Efficacy of sirolimus in treating tuberous sclerosis and lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Equivalent benefit of mTORC1 blockade and combined PI3K-mTOR blockade in a mouse model of tuberous sclerosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

p27Kip1 localization depends on the tumor suppressor protein tuberin

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

The tuberous sclerosis genes and regulation of the cyclin-dependent kinase inhibitor p27.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Mutation analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangioleiomyomatosis

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Ras, PI(3)K and mTOR signalling controls tumour cell growth

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27.

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Post-translational regulation of the tumor suppressor p27(KIP1).

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

AMPK: Lessons from transgenic and knockout animals

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

AMPK: an emerging drug target for diabetes and the metabolic syndrome

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.393

31 March 2020

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10.1038/ONC.2010.393

1 reference

Europe PubMed Central

31 July 2017

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1 reference

Europe PubMed Central

31 July 2017

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