The Shc locus regulates insulin signaling and adiposity in mammals (Q34147884)

31 July 2017

The Shc locus regulates insulin signaling and adiposity in mammals (English)

1 reference

31 July 2017

1 reference

Alexey A Tomilov

1

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31 July 2017

Jon J Ramsey

2

1 reference

31 July 2017

Kevork Hagopian

3

1 reference

31 July 2017

Marco Giorgio

4

1 reference

31 July 2017

Kyoungmi M Kim

5

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31 July 2017

Adam Lam

6

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31 July 2017

Enrica Migliaccio

7

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31 July 2017

Kent C Lloyd

8

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31 July 2017

Ina Berniakovich

9

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31 July 2017

Tomas A Prolla

10

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31 July 2017

Piergiuseppe Pelicci

11

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31 July 2017

Gino A Cortopassi

12

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31 July 2017

15 November 2010

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31 July 2017

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31 July 2017

10

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31 July 2017

55-65

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31 July 2017

1

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Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance

31 July 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

5 July 2018

P66Shc signals to age.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Fat tissue and long life.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Involvement of the p66Shc protein in glucose transport regulation in skeletal muscle myoblasts

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

p66Shc-generated oxidative signal promotes fat accumulation

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

SHC-1/p52Shc targets the insulin/IGF-1 and JNK signaling pathways to modulate life span and stress response in C. elegans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

p66shc negatively regulates insulin-like growth factor I signal transduction via inhibition of p52shc binding to Src homology 2 domain-containing protein tyrosine phosphatase substrate-1 leading to impaired growth factor receptor-bound protein-2 mem

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Adiponectin levels and genotype: a potential regulator of life span in humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Visceral adipose tissue modulates mammalian longevity

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

New findings in gene knockout, mutant and transgenic mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Remarkable longevity and stress resistance of nematode PI3K-null mutants

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

A systems biology approach for pathway level analysis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Brain IRS2 signaling coordinates life span and nutrient homeostasis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Akt/PKB regulates hepatic metabolism by directly inhibiting PGC-1alpha transcription coactivator.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The IGF-I signaling pathway

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Do longevity mutants always show trade-offs?

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Insulin signaling in human visceral and subcutaneous adipose tissue in vivo

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Extended longevity and insulin signaling in adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Suppression of aging in mice by the hormone Klotho

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Eicosapentaenoic fatty acid increases leptin secretion from primary cultured rat adipocytes: role of glucose metabolism

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Life extension in the dwarf mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The role of insulin and insulin-like growth factor-I in mammalian ageing

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

A cryptic targeting signal induces isoform-specific localization of p46Shc to mitochondria

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Insulin/IGF-I-signaling pathway: an evolutionarily conserved mechanism of longevity from yeast to humans

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Extended longevity in mice lacking the insulin receptor in adipose tissue

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Isoform-specific knockdown and expression of adaptor protein ShcA using small interfering RNA.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Feature extraction and normalization algorithms for high-density oligonucleotide gene expression array data

5 July 2018

2 references

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

5 July 2018

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The role of fat cell derived peptides in age-related metabolic alterations

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The role of fat depletion in the biological benefits of caloric restriction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

The p66shc adaptor protein controls oxidative stress response and life span in mammals

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Life without white fat: a transgenic mouse

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Sch proteins are localized on endoplasmic reticulum membranes and are redistributed after tyrosine kinase receptor activation.

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

5 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4157392

Gene expression profile of long-lived Ames dwarf mice and Little mice

5 July 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Impact of reduced insulin-like growth factor-1/insulin signaling on aging in mammals: novel findings.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Implications for the insulin signaling pathway in Snell dwarf mouse longevity: a similarity with the C. elegans longevity paradigm

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Low body temperature in long-lived Ames dwarf mice at rest and during stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1111%2FJ.1474-9726.2010.00641.X

Long-lived Klotho mice: new insights into the roles of IGF-1 and insulin in aging

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21040401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Effects of the Pit1 mutation on the insulin signaling pathway: implications on the longevity of the long-lived Snell dwarf mouse

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21040401

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1111/J.1474-9726.2010.00641.X

1 reference

31 July 2017

1 reference

31 July 2017

1 reference