20 years of leptin: connecting leptin signaling to biological function (Q34221428)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232147%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

review article

1 reference

title

20 years of leptin: connecting leptin signaling to biological function (English)

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16 February 2020

1

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16 February 2020

author name string

Martin G Myers

series ordinal

2

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16 February 2020

language of work or name

English

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publication date

1 October 2014

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16 February 2020

published in

Journal of Endocrinology

1 reference

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16 February 2020

volume

223

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16 February 2020

issue

1

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16 February 2020

page(s)

T25-35

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Leptin acts independently of food intake to modulate gut microbial composition in male mice

16 February 2020

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Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.

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Segregation of acute leptin and insulin effects in distinct populations of arcuate proopiomelanocortin neurons

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PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

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Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation

28 July 2018

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Functional role of suppressor of cytokine signaling 3 upregulation in hypothalamic leptin resistance and long-term energy homeostasis.

28 July 2018

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Insufficiency of Janus kinase 2-autonomous leptin receptor signals for most physiologic leptin actions

28 July 2018

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Acute administration of leptin produces anxiolytic-like effects: a comparison with fluoxetine

28 July 2018

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Enhanced Stat3 activation in POMC neurons provokes negative feedback inhibition of leptin and insulin signaling in obesity.

28 July 2018

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Leptin targets in the mouse brain

28 July 2018

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The geometry of leptin action in the brain: more complicated than a simple ARC.

28 July 2018

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Tyrosine-dependent and -independent actions of leptin receptor in control of energy balance and glucose homeostasis

28 July 2018

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Signal transducer and activator of transcription-3 is required in hypothalamic agouti-related protein/neuropeptide Y neurons for normal energy homeostasis

28 July 2018

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Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity

28 July 2018

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Specific physiological roles for signal transducer and activator of transcription 3 in leptin receptor-expressing neurons

28 July 2018

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Disruption of leptin receptor expression in the pancreas directly affects beta cell growth and function in mice

28 July 2018

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Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function

28 July 2018

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Leptin receptor signaling in midbrain dopamine neurons regulates feeding

28 July 2018

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Forkhead protein FoxO1 mediates Agrp-dependent effects of leptin on food intake

28 July 2018

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Leptin: a potential novel antidepressant

28 July 2018

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LRb-STAT3 signaling is required for the neuroendocrine regulation of energy expenditure by leptin

28 July 2018

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Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism

28 July 2018

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Modulation of direct leptin signaling by soluble leptin receptor

28 July 2018

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28 July 2018

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STAT3 signalling is required for leptin regulation of energy balance but not reproduction

28 July 2018

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Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

28 July 2018

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PTP1B regulates leptin signal transduction in vivo

28 July 2018

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Intracellular signalling. Key enzyme in leptin-induced anorexia

28 July 2018

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SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985

28 July 2018

1 reference

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Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

28 July 2018

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Activation of downstream signals by the long form of the leptin receptor

28 July 2018

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Central nervous system control of food intake

28 July 2018

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The role of SOCS-3 in leptin signaling and leptin resistance

28 July 2018

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Effects of recombinant leptin therapy in a child with congenital leptin deficiency.

28 July 2018

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Leptin and the regulation of body weight in mammals

28 July 2018

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Identification of SOCS-3 as a potential mediator of central leptin resistance

28 July 2018

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Fine structure of the murine leptin receptor gene: splice site suppression is required to form two alternatively spliced transcripts

28 July 2018

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Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding

28 July 2018

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Congenital leptin deficiency is associated with severe early-onset obesity in humans

28 July 2018

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28 July 2018

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Leptin accelerates the onset of puberty in normal female mice

28 July 2018

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Leptin receptor (OB-R) signaling. Cytoplasmic domain mutational analysis and evidence for receptor homo-oligomerization

28 July 2018

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The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors

28 July 2018

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Abnormal splicing of the leptin receptor in diabetic mice

28 July 2018

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Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice

28 July 2018

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Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor

28 July 2018

1 reference

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Identification and expression cloning of a leptin receptor, OB-R

28 July 2018

1 reference

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Positional cloning of the mouse obese gene and its human homologue

28 July 2018

1 reference

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Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity

28 July 2018

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Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects

28 July 2018

1 reference

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Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action

28 July 2018

1 reference

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Improved metabolic phenotype of hypothalamic PTP1B-deficiency is dependent upon the leptin receptor.

28 July 2018

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Neither signal transducer and activator of transcription 3 (STAT3) or STAT5 signaling pathways are required for leptin's effects on fertility in mice

28 October 2018

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Deficiency of PTP1B in leptin receptor-expressing neurons leads to decreased body weight and adiposity in mice.

28 October 2018

1 reference

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IRS2 signaling in LepR-b neurons suppresses FoxO1 to control energy balance independently of leptin action

28 October 2018

1 reference

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Shp2 controls female body weight and energy balance by integrating leptin and estrogen signals.

28 October 2018

1 reference

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Conditional gene targeting in mouse pancreatic ß-Cells: analysis of ectopic Cre transgene expression in the brain.

28 October 2018

1 reference

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Dominant role of the p110beta isoform of PI3K over p110alpha in energy homeostasis regulation by POMC and AgRP neurons

28 October 2018

1 reference

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The soluble leptin receptor neutralizes leptin-mediated STAT3 signalling and anorexic responses in vivo

28 October 2018

1 reference

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Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

28 October 2018

1 reference

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Activation of Stat3 signaling in AgRP neurons promotes locomotor activity

28 October 2018

1 reference

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The long form of the leptin receptor regulates STAT5 and ribosomal protein S6 via alternate mechanisms

28 October 2018

1 reference

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Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (Pomc) neurons causes decreased pomc expression, mild obesity, and defects in compensatory refeeding

28 October 2018

1 reference

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Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.

28 October 2018

1 reference

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Neuronal PTP1B regulates body weight, adiposity and leptin action.

28 October 2018

1 reference

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Role of hypothalamic Foxo1 in the regulation of food intake and energy homeostasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in mice

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Roles for leptin receptor/STAT3-dependent and -independent signals in the regulation of glucose homeostasis

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

SH2-B promotes insulin receptor substrate 1 (IRS1)- and IRS2-mediated activation of the phosphatidylinositol 3-kinase pathway in response to leptin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Role of Signal Transducer and Activator of Transcription 3 in Regulation of Hypothalamic Proopiomelanocortin Gene Expression by Leptin

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Regulation of Jak kinases by intracellular leptin receptor sequences.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Divergent roles of SHP-2 in ERK activation by leptin receptors

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

In vivo administration of leptin activates signal transduction directly in insulin-sensitive tissues: overlapping but distinct pathways from insulin

28 October 2018

1 reference

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Expression of leptin receptor isoforms in rat brain microvessels.

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

The soluble leptin receptor is crucial for leptin action: evidence from clinical and experimental data

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4170570

Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor

28 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25232147

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Chemical characterization of leptin-activated neurons in the rat brain

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25232147

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Relationship between serum leptin and fatty liver in Japanese male adolescent university students

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25232147

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1530/JOE-14-0404

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232147%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25232147%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference