BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies (Q34252163)

31 July 2017

title

BRCA1-directed, enhanced and aberrant homologous recombination: mechanism and potential treatment strategies (English)

1 reference

31 July 2017

Seth M Dever

1

1 reference

31 July 2017

E Railey White

series ordinal

2

1 reference

31 July 2017

Matthew C T Hartman

series ordinal

3

1 reference

31 July 2017

Kristoffer Valerie

series ordinal

4

1 reference

31 July 2017

publication date

15 February 2012

1 reference

31 July 2017

number of pages

8

1 reference

inferred from page(s)

published in

Cell Cycle

1 reference

31 July 2017

volume

11

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31 July 2017

issue

4

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31 July 2017

page(s)

687-694

1 reference

In vitro selection of unnatural cyclic peptide libraries via mRNA display

31 July 2017

cites work

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BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity

6 July 2018

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Cancer. BRCA1, everything but the RING?

6 July 2018

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SUMO playing tag with ubiquitin

6 July 2018

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Functional connection between Rad51 and PML in homology-directed repair

6 July 2018

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6 July 2018

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BRCA1 tumour suppression occurs via heterochromatin-mediated silencing.

6 July 2018

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BRCA1 A‐complex fine tunes repair functions of BRCA1.

6 July 2018

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p53-dependent BRCA1 nuclear export controls cellular susceptibility to DNA damage

6 July 2018

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BRCT domains: easy as one, two, three

6 July 2018

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Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

6 July 2018

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6 July 2018

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Synthetic lethality of PARP inhibition in cancers lacking BRCA1 and BRCA2 mutations

6 July 2018

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RAP80-directed tuning of BRCA1 homologous recombination function at ionizing radiation-induced nuclear foci

6 July 2018

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The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection

6 July 2018

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BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

6 July 2018

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AKT1/BRCA1 in the control of homologous recombination and genetic stability: the missing link between hereditary and sporadic breast cancers

6 July 2018

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Homologous recombination repair is essential for repair of vosaroxin-induced DNA double-strand breaks

6 July 2018

1 reference

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Comprehensive analysis of missense variations in the BRCT domain of BRCA1 by structural and functional assays.

6 July 2018

1 reference

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Fine tuning chemotherapy to match BRCA1 status

6 July 2018

1 reference

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Toward classification of BRCA1 missense variants using a biophysical approach.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Identification of Filamin A as a BRCA1-interacting protein required for efficient DNA repair

6 July 2018

1 reference

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

BRCA1 and its toolbox for the maintenance of genome integrity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.

6 July 2018

1 reference

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The ubiquitin landscape at DNA double-strand breaks

6 July 2018

1 reference

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MRG15 is a novel PALB2-interacting factor involved in homologous recombination

6 July 2018

1 reference

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

6 July 2018

1 reference

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PALB2 is an integral component of the BRCA complex required for homologous recombination repair

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

PALB2 links BRCA1 and BRCA2 in the DNA-damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

6 July 2018

1 reference

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E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks

6 July 2018

1 reference

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Linking the cellular functions of BRCA genes to cancer pathogenesis and treatment

6 July 2018

1 reference

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Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interaction

6 July 2018

1 reference

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The challenge of drugging undruggable targets in cancer: lessons learned from targeting BCL-2 family members

6 July 2018

1 reference

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Human CtIP promotes DNA end resection

6 July 2018

1 reference

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Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

6 July 2018

1 reference

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Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

CCDC98 targets BRCA1 to DNA damage sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Pitfalls and caveats in BRCA sequencing

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Enzymatic aminoacylation of tRNA with unnatural amino acids

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

PML nuclear bodies: dynamic sensors of DNA damage and cellular stress

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Structure of the BRCT Repeats of BRCA1 Bound to a BACH1 Phosphopeptide

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Small-molecule inhibitors of protein-protein interactions: progressing towards the dream

6 July 2018

1 reference

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

6 July 2018

1 reference

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Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains

6 July 2018

1 reference

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The BRCT Domain Is a Phospho-Protein Binding Domain

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Binding and recognition in the assembly of an active BRCA1/BARD1 ubiquitin-ligase complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Structure of a BRCA1-BARD1 heterodimeric RING-RING complex

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

BRCA1 RING domain cancer-predisposing mutations. Structural consequences and effects on protein-protein interactions

6 July 2018

1 reference

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Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Role for ATM in DNA damage-induced phosphorylation of BRCA1

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Genetic analysis of BRCA1 function in a defined tumor cell line

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

6 July 2018

1 reference

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Improved survival in women with BRCA-associated ovarian carcinoma

6 July 2018

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The RING heterodimer BRCA1-BARD1 is a ubiquitin ligase inactivated by the platinum-based anticancer drugs

21 January 2018

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Thiolate bridging and metal exchange in adducts of a zinc finger model and Pt(II) complexes: biomimetic studies of protein/Pt/DNA interactions

21 January 2018

1 reference

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Cisplatin Affects the Conformation of Apo Form, not Holo Form, of BRCA1 RING Finger Domain and Confers Thermal Stability

21 January 2018

1 reference

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High-throughput fluorescence polarization assay to identify small molecule inhibitors of BRCT domains of breast cancer gene 1.

21 January 2018

1 reference

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Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling

21 January 2018

1 reference

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Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation

28 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3318103

“BRCAness” Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated WithBRCA1andBRCA2Mutations

28 October 2018

1 reference

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Thermodynamics of phosphopeptide tethering to BRCT: the structural minima for inhibitor design

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22306997

12 December 2020

inferred from PubMed ID database lookup

BRCA1 regulation of base excision repair pathway

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22306997

12 December 2020

inferred from PubMed ID database lookup

Stapled peptides: Magic bullets in nature's arsenal

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22306997

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.4161/CC.11.4.19212

1 reference

31 July 2017

1 reference

31 July 2017

1 reference