The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection (Q34787446)

4 August 2017

The BRCA1-RAP80 complex regulates DNA repair mechanism utilization by restricting end resection (English)

1 reference

4 August 2017

Kara A Coleman

1

1 reference

4 August 2017

Roger A Greenberg

series ordinal

2

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4 August 2017

language of work or name

English

0 references

publication date

18 February 2011

1 reference

Journal of Biological Chemistry

4 August 2017

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4 August 2017

286

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4 August 2017

15

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4 August 2017

13669-13680

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describes a project that uses

4 August 2017

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3075711/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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53BP1 loss rescues BRCA1 deficiency and is associated with triple-negative and BRCA-mutated breast cancers

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8 July 2018

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8 July 2018

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8 July 2018

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8 July 2018

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Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function

8 July 2018

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PALB2 links BRCA1 and BRCA2 in the DNA-damage response

8 July 2018

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NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control

8 July 2018

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MERIT40 facilitates BRCA1 localization and DNA damage repair

8 July 2018

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MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks

8 July 2018

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RNF168 binds and amplifies ubiquitin conjugates on damaged chromosomes to allow accumulation of repair proteins

8 July 2018

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8 July 2018

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Human CtIP mediates cell cycle control of DNA end resection and double strand break repair

8 July 2018

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The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks

8 July 2018

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DNA helicases Sgs1 and BLM promote DNA double-strand break resection

8 July 2018

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8 July 2018

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Cell cycle-dependent complex formation of BRCA1.CtIP.MRN is important for DNA double-strand break repair.

8 July 2018

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Regulation of DNA double-strand break repair pathway choice

8 July 2018

1 reference

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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage

8 July 2018

1 reference

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Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase

8 July 2018

1 reference

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RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

8 July 2018

1 reference

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RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Human CtIP promotes DNA end resection

8 July 2018

1 reference

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Sequential and synergistic modification of human RPA stimulates chromosomal DNA repair

8 July 2018

1 reference

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CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

CCDC98 targets BRCA1 to DNA damage sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Molecular mechanisms of sister-chromatid exchange

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Mechanism of homologous recombination: mediators and helicases take on regulatory functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Human SMC5/6 complex promotes sister chromatid homologous recombination by recruiting the SMC1/3 cohesin complex to double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Regulation of DNA repair by ubiquitylation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

RAD50 and NBS1 are breast cancer susceptibility genes associated with genomic instability

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Control of sister chromatid recombination by histone H2AX.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Genetic steps of mammalian homologous repair with distinct mutagenic consequences

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

From silencing to gene expression: real-time analysis in single cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Cancer susceptibility and the functions of BRCA1 and BRCA2

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Detection of repair activity during the DNA damage-induced G2 delay in human cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

DNA damage-dependent nuclear dynamics of the Mre11 complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

DNA double strand break repair in mammalian cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Genetic analysis of BRCA1 function in a defined tumor cell line

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

A recurrent mutation in PALB2 in Finnish cancer families.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

The emerging landscape of breast cancer susceptibility

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

Truncating mutations in the Fanconi anemia J gene BRIP1 are low-penetrance breast cancer susceptibility alleles

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

THE GENETICS OF BREAST CANCER SUSCEPTIBILITY

9 December 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3075711

9 December 2018

Identifiers

DOI

10.1074/JBC.M110.213728

1 reference

4 August 2017

1 reference

4 August 2017

1 reference